1921
Volume s1-18, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Introduction

In 1933 Eaton (1), in a preliminary paper, announced to the National Malaria Committee his belief that the red blood corpuscles of man were susceptible to infection by malaria parasites only while in the reticulocyte stage. This hypothesis he based primarily on two observations which he had made during the examination of blood specimens. The first was the multiple infection of erythrocytes with ; and second, the ratio of infected young red blood cells (reticulocytes) to that of infected mature cells, which, for example, was 23.0 to 1.8 per cent in one of his counts.

Considering that normally the reticulocytes constitute approximately only from ½ to 1½ per cent of the total number of red blood cells found in the peripheral circulation, this relatively high infection percentage, coupled with the observed multiple infected erythrocytes, indicated to Eaton a restriction of red cell susceptibility and pointed to the reticulocyte as the natural cell host of the malaria parasite.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1938.s1-18.361
1938-07-01
2017-11-17
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1938.s1-18.361
Loading
  • Received : 26 May 1937

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error