Volume s1-3, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The Weil-Felix reaction has received general acceptance as an empiric laboratory test of considerable merit in establishing the diagnosis of typhus fever. The testimony of writers is uniform in affirming that the reaction is positive in over 90 per cent of cases of clinical typhus. It may appear as early as the fourth day of the disease, but usually does not develop until the second week and yields maximal titres about the time that the temperature returns to normal or shortly thereafter. Complete agglutination of the strain of known as X in a dilution of the patient's serum greater than 1:50 is looked upon as of specific diagnostic significance. So far as can be determined the organism has no etiologic relationship to the disease and the mechanism of the reaction is not clearly understood. An excellent discussion of the immunological principles involved and the technique of the reaction has been published by Bengtson in the Public Health Reports, October 31, 1919.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error