1921
Volume 102, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD
Buy:$15.00

Abstract

Abstract.

Elevated circulating endotoxin levels in the plasma of patients with advanced hepatosplenic schistosomiasis caused by have been reported, possibly caused by parasite egg–induced intestinal mucosal breaches facilitating bacterial access to the bloodstream. Neither endotoxin levels in people with but without hepatosplenic disease nor the impact of treatment on endotoxin levels have been described. We used a methodically optimized amebocyte lysate assay to measure plasma endotoxin in community-dwelling women from an endemic area without clinical hepatosplenic disease. We found no difference in baseline mean plasma endotoxin levels between those with ( = 22) and without ( = 31) infection (1.001 versus 0.949 EU/mL, = 0.61). Endotoxin levels did not change in schistosome-infected women after successful treatment (1.001 versus 1.093 EU/mL, = 0.45) and were not correlated with circulating anodic antigen or stool egg burden. Our findings do not support the hypothesis that translocating eggs in infection introduce bacterial sources of endotoxin to the circulation.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.19-0875
2020-03-02
2020-09-25
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.19-0875
Loading
/content/journals/10.4269/ajtmh.19-0875
Loading

Data & Media loading...

  • Received : 27 Nov 2019
  • Accepted : 23 Jan 2020
  • Published online : 02 Mar 2020
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error