1921
Volume 102, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Acute intravascular hemolysis (AIH) with hemoglobinuria is a rare complication of dengue viral infection. Review of the literature revealed only one report of AIH as a complication of dengue fever (DF). We report a case of AIH with massive hemoglobinuria in a 17-year-old Sri Lankan male, in the febrile phase of DF. This unusual and rare complication warranted forced diuresis, to prevent acute kidney injury. This was a departure from the recommended fluid therapy for DF.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.19-0743
2020-01-06
2021-01-25
Loading full text...

Full text loading...

/deliver/fulltext/14761645/102/2/tpmd190743.html?itemId=/content/journals/10.4269/ajtmh.19-0743&mimeType=html&fmt=ahah

References

  1. Simmons CP, Farrar JJ, Van Vinh Chau N, Wills B, 2012. Current concepts: dengue. N Engl J Med 366: 14231432.
    [Google Scholar]
  2. Kularatne SA, 2015. Dengue fever. BMJ 351: h4663.
    [Google Scholar]
  3. Muller DA, Depelsenaire AC, Young PR, 2017. Clinical and laboratory diagnosis of dengue virus infection. J Infect Dis 215 (Suppl 2): S89S95.
    [Google Scholar]
  4. Biswas S, Kumar P, Tansir G, Biswas A, 2019. Case report: cardiac tamponade in dengue hemorrhagic fever: an unusual manifestation of a common disease. Am J Trop Med Hyg 101: 448450.
    [Google Scholar]
  5. Verma R, Sahu R, Holla V, 2014. Neurological manifestations of dengue infection: a review. J Neurol Sci 346: 2634.
    [Google Scholar]
  6. Weerasinghe WS, Medagama A, 2019. Dengue hemorrhagic fever presenting as encephalitis: a case report. J Med Case Rep 13: 278.
    [Google Scholar]
  7. Merle H, Donnio A, Jean-Charles A, Guyomarch J, Hage R, Najioullah F, Césaire R, Cabié A, 2018. Ocular manifestations of emerging arboviruses: dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever. J Fr Ophtalmol 41: 659668.
    [Google Scholar]
  8. Ng AW, Teoh SC, 2015. Dengue eye disease. Surv Ophthalmol 60: 106114.
    [Google Scholar]
  9. Dalugama C, Gawarammana IB, 2017. Dengue hemorrhagic fever complicated with acute liver failure: a case report. J Med Case Rep 11: 341.
    [Google Scholar]
  10. de Almeida RR, Paim B, de Oliveira SA, Souza AS Jr., Gomes ACP, Escuissato DL, Zanetti G, Marchiori E, 2017. Dengue hemorrhagic fever: a state-of-the-art review focused in pulmonary involvement. Lung 195: 389395.
    [Google Scholar]
  11. Vachvanichsanong P, Thisyakorn U, Thisyakorn C, 2016. Dengue hemorrhagic fever and the kidney. Arch Virol 161: 771778.
    [Google Scholar]
  12. Dalugama C, Gawarammana IB, 2018. Lessons learnt from managing a case of dengue hemorrhagic fever complicated with acute liver failure and acute kidney injury: a case report. J Med Case Rep 12: 215.
    [Google Scholar]
  13. Gubler DJ, 1998. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11: 480486.
    [Google Scholar]
  14. Pang X, Zhang R, Cheng G, 2017. Progress towards understanding the pathogenesis of dengue hemorrhagic fever. Virol Sin 32: 1622.
    [Google Scholar]
  15. Aye M, Cabot J, William LWK, 2016. Severe dengue fever with haemolytic anaemia. A case Study. Trop Med Infect Dis 1: E6.
    [Google Scholar]
  16. Medagoda K, Gunathilaka SB, De Silva HJ, 2003. A case of self-limiting Coomb’s negative haemolytic anaemia following dengue shock syndrome. Ceylon Med J 48: 147148.
    [Google Scholar]
  17. Qiu FX, Chen QQ, Ho QY, Chen WZ, Zhao ZG, Zhao BW, 1991. The first epidemic of dengue hemorrhagic fever in the People’s Republic of China. Am J Trop Med Hyg 44: 364370.
    [Google Scholar]
  18. Ministry of Health-Sri Lanka, 2012. National Guidelines on Management of Dengue Fever and Dengue Hemorrhagic Fever. Available at: http://www.epid.gov.lk/. Accessed December 27, 2019.
    [Google Scholar]
  19. Brodsky RA, 2019. Warm autoimmune hemolytic anemia. N Engl J Med 381: 647654.
    [Google Scholar]
  20. Garbe E et al., 2011. Drug induced immune haemolytic anaemia in the Berlin case-control surveillance study. Br J Haematol 154: 644653.
    [Google Scholar]
  21. Barber BE, Grigg MJ, Piera KA, William T, Cooper DJ, Plewes K, Dondorp AM, Yeo TW, Anstey NM, 2018. Intravascular haemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury. Emerg Microbes Infect 7: 106.
    [Google Scholar]
  22. Cappellini MD, Fiorelli G, 2008. Glucose-6-phosphate dehydrogenase deficiency. Lancet 371: 6474.
    [Google Scholar]
  23. Youngster I, Arcavi L, Schechmaster R, Akayzen Y, Popliski H, Shimonov J, Beig S, Berkovitch M, 2010. Medications and glucose-6-phosphate dehydrogenase deficiency. Drug Safety 33: 713726.
    [Google Scholar]
  24. Luzzatto L, Seneca E, 2014. G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications. Br J Haematol 164: 469480.
    [Google Scholar]
  25. Beutler E, 2008. Glucose-6-phosphate dehydrogenase deficiency: a historical perspective. Blood 111: 1624.
    [Google Scholar]
  26. Sellahewa K, 1994. Acalypha indica induced haemolysis in G6PD deficiency. Ceylon Med J 39: 145.
    [Google Scholar]
  27. Deuel JW, Schaer CA, Boretti FS, Opitz L, Garcia-Rubio I, Baek JH, Spahn DR, Buehler PW, Schaer DJ, 2016. Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response. Cell Death Dis 7: e2064.
    [Google Scholar]
  28. Rifkind JM, Mohanty JG, Nagababu E, 2015. The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions. Front Physiol 5: 500.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.19-0743
Loading
/content/journals/10.4269/ajtmh.19-0743
Loading

Data & Media loading...

  • Received : 07 Oct 2019
  • Accepted : 02 Dec 2019
  • Published online : 06 Jan 2020
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error