1921
Volume 102, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Typhoid conjugate vaccines represent a new tool for typhoid control. However, incidence data are needed to inform decisions about introduction. We sought to estimate typhoid and paratyphoid fever incidence in Vientiane, the capital and largest city of the Lao People’s Democratic Republic (Lao PDR). We did a representative cluster survey of health-seeking behavior for fever in Vientiane from January 15, 2019 through January 26, 2019. Multipliers derived from the survey were applied to data from Typhi and Paratyphi A bloodstream infection surveillance from Mahosot Hospital, Vientiane, for the period of January 1, 2015 through December 31, 2017, to estimate enteric fever incidence. A total of 336 households representing 1,740 persons were enrolled in the healthcare utilization survey, and multipliers were derived based on responses to questions about healthcare seeking in the event of febrile illness. Of 7,997 Vientiane residents receiving blood cultures over the 2-year surveillance period at Mahosot Hospital, we identified 16 (0.2%) with Typhi and six (< 0.1%) with Paratyphi A bloodstream infection. After applying multipliers, we estimated that the annual incidence of typhoid was 4.7 per 100,000 persons and paratyphoid was 0.5 per 100,000 persons. During the study period, the incidence of typhoid and paratyphoid fever was low in Vientiane. Ongoing surveillance is warranted to identify increases in future years. Similar studies elsewhere in the Lao PDR would be useful to understand the wider enteric fever situation in the country.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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References

  1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators, 2018. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392: 17891858.
    [Google Scholar]
  2. GBD 2017 Causes of Death Collaborators, 2018. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392: 17361788.
    [Google Scholar]
  3. GBD 2017 Typhoid and Paratyphoid Collaborators, 2019. The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect Dis 19: 369381.
    [Google Scholar]
  4. Marchello CS, Dale AP, Pisharody S, Rubach MP, Crump JA, 2020. Prevalence of community-onset bloodstream infections among hospitalized patients in Africa and Asia: a systematic review and meta-analysis. Antimicrob Agents Chemother 64: e0197419.
    [Google Scholar]
  5. Phetsouvanh R et al., 2006. Causes of community-acquired bacteremia and patterns of antimicrobial resistance in Vientiane, Laos. Am J Trop Med Hyg 75: 978985.
    [Google Scholar]
  6. Mayxay M et al., 2013. Causes of non-malarial fever in Laos: a prospective study. Lancet Glob Health 1: e46e54.
    [Google Scholar]
  7. Murray CJ, 1994. Quantifying the burden of disease: the technical basis for disability-adjusted life years. Bull World Health Organ 72: 429445.
    [Google Scholar]
  8. Crump JA, Youssef FG, Luby SP, Wasfy MO, Rangel JM, Talaat M, Oun SA, Mahoney FJ, 2003. Estimating the incidence of typhoid fever and other febrile illnesses in developing countries. Emerg Infect Dis 9: 539544.
    [Google Scholar]
  9. Andrews JR, Barkume C, Yu AT, Saha SK, Qamar FN, Garrett D, Luby SP, 2018. Integrating facility-based surveillance with healthcare utilization surveys to estimate enteric fever incidence: methods and challenges. J Infect Dis 218 (Suppl 4): S268S276.
    [Google Scholar]
  10. World Health Organization, 2019. Typhoid vaccines: WHO position paper, March 2018: recommendations. Vaccine 37: 214216.
    [Google Scholar]
  11. Roberts T et al., 2020. Typhoid in Laos: an 18 year perspective. Am J Trop Med Hyg 102: 749757.
    [Google Scholar]
  12. Lao Statistic Bureau, 2015. Provisional Report Lao Population and Housing Census. Vientiane, Lao PDR: Lao Statistic Bureau.
    [Google Scholar]
  13. Oo WT, Myat TO, Htike WW, Ussher JE, Murdoch DR, Lwin KT, Oo MZ, Maze MJ, Win HH, Crump JA, 2019. Incidence of typhoid and paratyphoid fevers among adolescents and adults in Yangon, Myanmar. Clin Infect Dis 68 (Suppl 2): S124S129.
    [Google Scholar]
  14. WHO, 2015. World Health Organization Vaccination Coverage Cluster Surveys: Reference Manual. Geneva, Swizterland: World Health Organisation.
    [Google Scholar]
  15. Maze MJ et al., 2016. Comparison of the estimated incidence of acute leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14. PLoS Negl Trop Dis 10: e0005165.
    [Google Scholar]
  16. Marks F et al., 2017. Incidence of invasive Salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study. Lancet Glob Health 5: e310e323.
    [Google Scholar]
  17. Weinstein MP, Towns ML, Quartey SM, Mirrett S, Reimer LG, Parmigiani G, Reller LB, 1997. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 24: 584602.
    [Google Scholar]
  18. Douglas MW, Lum G, Roy J, Fisher DA, Anstey NM, Currie BJ, 2004. Epidemiology of community-acquired and nosocomial bloodstream infections in tropical Australia: a 12-month prospective study. Trop Med Int Health 9: 795804.
    [Google Scholar]
  19. Clinical Laboratories Standards Institute, 2015. Performance Standards for Antimicrobial Susceptibility Testing: 25th Informational Supplement. CLSI Document M100-S25. Wayne, PA: Clinical Laboratories Standards Institute.
    [Google Scholar]
  20. Gilman RH, Terminel M, Levine MM, Hernandez-Mendoza P, Hornick RB, 1975. Relative efficacy of blood, urine, rectal swab, bone-marrow, and rose-spot cultures for recovery of Salmonella Typhi in typhoid fever. Lancet 1: 12111213.
    [Google Scholar]
  21. Mogasale V, Ramani E, Mogasale VV, Park J, 2016. What proportion of Salmonella Typhi cases are detected by blood culture? A systematic literature review. Ann Clin Microbiol Antimicrob 15: 32.
    [Google Scholar]
  22. Ochiai RL et al., Domi Typhoid Study Group, 2008. A study of typhoid fever in five Asian countries: disease burden and implications for controls. Bull World Health Organ 86: 260268.
    [Google Scholar]
  23. Mitra M, Shah N, Ghosh A, Chatterjee S, Kaur I, Bhattacharya N, Basu S, 2016. Efficacy and safety of vi-tetanus toxoid conjugated typhoid vaccine (PedaTyph™) in Indian children: school based cluster randomized study. Hum Vaccin Immunother 12: 939945.
    [Google Scholar]
  24. Marchello CS, Hong CY, Crump JA, 2019. Global typhoid fever incidence: a systematic review and meta-analysis. Clin Infect Dis 68 (Suppl 2): S105S116.
    [Google Scholar]
  25. WHO, UNICEF, 2015. Progress on Sanitation and Drinking Water: 2015 Update and MDG Assessment. Geneva, Switzerland: World Health Organization, 80.
    [Google Scholar]
  26. Saha SK, Baqui AH, Hanif M, Darmstadt GL, Ruhulamin M, Nagatake T, Santosham M, Black RE, 2001. Typhoid fever in Bangladesh: implications for vaccination policy. Ped Infect Dis J 20: 521524.
    [Google Scholar]
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  • Received : 26 Aug 2019
  • Accepted : 14 Jan 2020
  • Published online : 02 Mar 2020
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