image of High Rates of New Delhi Metallo-β-Lactamase Carbapenemase Genes in Multidrug-Resistant Gram-Negative Rods in Nicaragua
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Antimicrobial resistance (AMR) is a global public health crisis. Much of the burden of AMR in resource-limited settings remains unknown. This pilot study characterized clinical isolates of multidrug-resistant Gram-negative rods (MDR-GNRs) from Nicaragua. New Delhi metallo-β-lactamase (NDM) carbapenemase genes were detected in 60% of isolates. had the highest rates of NDM detection, with 92% (50/54 isolates) positive by PCR. PFGE analysis revealed patterns of clustering among isolates by two factors: plasmid profiles and year of culture. These findings of very high rates of NDM-carbapenemase genes in MDR-GNRs from hospitals throughout Nicaragua are alarming. Further research is needed to determine clinical and epidemiologic factors associated with multidrug-resistant isolates and to guide interventions to limit further spread.


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  • Received : 28 Jul 2019
  • Accepted : 14 Oct 2019
  • Published online : 25 Nov 2019
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