1921
image of Serum IL-10 Levels and Its Relationship with Parasitemia in Chronic Chagas Disease Patients
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

It is known that the immunoregulatory networks in human Chagas disease play a key role in parasitemia control during the acute phase. However, little is known regarding the control of parasitemia during the chronic phase. The aim of the study was to describe the serum cytokine profile of chronically infected patients and to evaluate its relationship with the presence or absence of parasitemia in peripheral blood. This is a prospective observational study where adult Chagas disease patients were included. Patients previously treated for Chagas disease, pregnant women, and immunosuppressed patients were excluded. Demographic and clinical information was collected, and real-time polymerase chain reaction (RT-PCR) and serum cytokine profile were determined in peripheral blood. Forty-five patients were included. RT-PCR in peripheral blood resulted positive in 19 (42.2%) patients. No differences in the serum cytokine profile were found depending on cardiac or digestive involvement. However, patients with positive RT-PCR had a higher median concentration of IL-10 and IL-1beta and a lower median concentration of IL-8 than those with negative PCR. These results reinforce the key role that this anti-inflammatory cytokine (IL-10) plays in parasitemia control.

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/content/journals/10.4269/ajtmh.19-0550
2019-11-04
2019-11-21
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.19-0550
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  • Received : 24 Jul 2019
  • Accepted : 23 Sep 2019
  • Published online : 04 Nov 2019
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