Volume 102, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



(), a gram-negative pathogen, has been shown to colonize multiple organs and cause various forms of extra-gastrointestinal diseases. The association of infection with vitamin D status in apparently healthy children remained unclear; therefore, we investigated the relationship between vitamin D and infection among apparently healthy infants and toddlers. In this large cross-sectional study, the examination data of children were collected from January 2013 to September 2017 in the Center for Children’s Health Care. Among these children, 6,896 infants and toddlers were screened for our study. infection and vitamin D status were the main indicators, and micronutrients (zinc, iron, copper, magnesium), and growth parameters (height, weight, and weight for age score [WAZ], height for age score [HAZ]) were also analyzed in this study. Among the 6,896 infants and toddlers, the detection rate of seropositivity was 30.6%. The prevalence of vitamin D deficiency in seropositive and seronegative groups was 20.7% and 12.1%, respectively ( < 0.001). The logistic regression analysis suggested children with –positive antibody were 2.06 times more likely to be vitamin D deficient compared with children who had negative antibody (odds ratio: 2.06; 95% CI: 1.77, 2.38) after controlling for confounding factors. These data suggested that there was a significant association between seropositivity and vitamin D deficiency in children aged 6–36 months, which would make a contribution to the treatment and monitoring of vitamin D deficiency and infection.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...


Data & Media loading...

  • Received : 13 Jul 2019
  • Accepted : 05 Dec 2019
  • Published online : 13 Jan 2020
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error