1921
Volume 102, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

American visceral leishmaniasis (VL) is a vector-borne disease caused by (syn. ) and transmitted by and phlebotomine sand flies. Dogs not only are the main host reservoirs of the parasite but also suffer the disease; therefore, canine VL (CVL) has assumed an important role in public health. In Colombia, human and CVL are restricted to two transmission foci: one in the north region (Caribbean coast) and other in the central south region (middle Magdalena River Valley). We present a CVL case involving a 2-year-old male dog with a history of lack of appetite, general weakness, and progressive loss of weight. A diagnosis of CVL was obtained using the direct parasitological examination in spleen and bone marrow samples stained with Giemsa and RT-qPCR. The infecting species was identified as by PCR–restriction fragment length polymorphism amplifying the gene from bone marrow and spleen samples and confirming by sequencing. The patient responded favorably to treatment with intramuscular meglumine antimoniate at a dose of 100 mg/kg daily for 8 weeks and oral allopurinol at a dose of 10 mg/kg every 12 hours until new indication. This is the first report of urban CVL in the city of Cali, Colombia, highlighting the need for surveillance and control programs in the municipalities of the department of Valle del Cauca, a region where VL has not been informed before. The findings also indicate the need to reinforce the surveillance programs in other rural and urban regions of the country where favorable eco-epidemiological conditions exist.

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References

  1. WHO Expert Committee on the Control of the Leishmaniases and World Health Organization, 2010. Control of the Leishmaniases: Report of a Meeting of the WHO Expert Commitee on the Control of Leishmaniases, March 22–26, 2010, Geneva, Switzerland: WHO. Available at: http://www.who.int/iris/handle/10665/44412. Accessed May 10, 2019.
    [Google Scholar]
  2. Carvalho AG, Luz JGG, Rodrigues LD, Dias JV, Fontes CJF, 2018. High seroprevalence and peripheral spatial distribution of visceral leishmaniasis among domestic dogs in an emerging urban focus in central Brazil: a cross-sectional study. Pathog Glob Health 112: 2936.
    [Google Scholar]
  3. Michelin A de F, Oliveira dos Santos Maciel M, Okajima M, Maroni Nunes C, Venturoli Perri SH, Bonfietti LX, 2017. Factors associated with positivity for canine visceral leishmaniosis in an endemic area in Brazil. Vet Parasitol Reg Stud Reports 12: 1316.
    [Google Scholar]
  4. Dantas-Torres F, 2007. The role of dogs as reservoirs of Leishmania parasites, with emphasis on Leishmania (Leishmania) infantum and Leishmania (Viannia) braziliensis. Vet Parasitol 149: 1391346.
    [Google Scholar]
  5. Travi BL, Osorio Y, Becerra MT, Adler GH, 1998. Dynamics of Leishmania chagasi infection in small mammals of the undisturbed and degraded tropical dry forests of northern Colombia. Trans R Soc Trop Med Hyg 92: 275278.
    [Google Scholar]
  6. Zambrano-Hernandez P et al., 2015. Brote urbano de leishmaniasis visceral en Neiva, Colombia. Rev Salud Pública 17: 514527.
    [Google Scholar]
  7. Vivero RJ, Jaramillo NG, Cadavid-Restrepo G, Soto SI, Herrera CX, 2016. Structural differences in gut bacteria communities in developmental stages of natural populations of Lutzomyia evansi from Colombia’s Caribbean coast. Parasit Vectors 9: 496.
    [Google Scholar]
  8. Bejarano EE, Estrada LG, 2016. Family Psychodidae. Zootaxa 41222: 187238.
    [Google Scholar]
  9. Acosta LA, Mondragón-Shem K, Vergara D, Vélez-Mira A, Cadena H, Carrillo Bonilla L, 2013. Expansion of the distribution of Lutzomyia longipalpis (Lutz & Neiva, 1912) (Diptera: Psychodidae) in the department of Caldas: increased risk of visceral leishmaniasis [article in Spanish]. Biomedica 33: 319325.
    [Google Scholar]
  10. González C, Cabrera OL, Munstermann LE, Ferro C, 2006. Distribution of Leishmania infantum vector species in Colombia [article in Spanish]. Biomedica 26: 6472.
    [Google Scholar]
  11. Travi BL, Vélez ID, Brutus L, Segura I, Jaramillo C, Montoya J, 1990. Lutzomyia evansi, an alternate vector of Leishmania chagasi in a Colombian focus of visceral leishmaniasis. Trans R Soc Trop Med Hyg 84: 676677.
    [Google Scholar]
  12. Ribeiro RR, Michalick MSM, da Silva ME, Dos Santos CCP, Frézard FJG, da Silva SM, 2018. Canine leishmaniasis: an overview of the current status and strategies for control. Biomed Res Int 2018: 3296893.
    [Google Scholar]
  13. Reguera RM, Moran M, Perez-Pertejo Y, -Estrada C, Balana-Fouce R, 2016. Current status on prevention and treatment of canine leishmaniasis. Vet Parasitol 227: 98114.
    [Google Scholar]
  14. Carrillo-Bonilla LM, Montoya A, Arbeláez N, Cadena H, Ramírez J, Robledo SM, 2014. Migración de Leishmania panamensis y su persistencia en piel sana de hamster. Rev UDCA Actual Divulg Cient 17: 341350.
    [Google Scholar]
  15. Montalvo AM, Fraga J, Tirado D, Blandón G, Alba A, Van der Auwera G, Vélez ID, Muskus C, 2017. Detection and identification of Leishmania spp.: application of two hsp70-based PCR-RFLP protocols to clinical samples from the New World. Parasitol Res 116: 18431848.
    [Google Scholar]
  16. Marcondes M, Day JM, 2019. Current status and management of canine leishmaniasis in Latin America. Res Vet Sci 123: 261272.
    [Google Scholar]
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  • Received : 10 Jul 2019
  • Accepted : 09 Oct 2019
  • Published online : 02 Dec 2019
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