1921
image of Mannose-Binding Lectin and MBL-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are important proteins in the lectin pathway of the immune system. Mannose-binding lectin and MASP-2 deficiencies have been reported to be responsible for various fungal infections. We investigated the association of MBL and MASP-2 variants with sporotrichosis in a Chinese population and revealed one rare heterozygous mutation in a disseminated cutaneous patient without immunosuppressive conditions (p.156_159dupCHNH). We also found that sporotrichosis patients had decreased levels of MBL and MASP-2 in their serum samples compared with controls. Our findings linked, for the first time, MASP-2 deficiencies with susceptibility to sp.

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/content/journals/10.4269/ajtmh.19-0470
2019-09-23
2019-11-21
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.19-0470
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  • Received : 21 Jun 2019
  • Accepted : 20 Aug 2019
  • Published online : 23 Sep 2019
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