Volume 101, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are important proteins in the lectin pathway of the immune system. Mannose-binding lectin and MASP-2 deficiencies have been reported to be responsible for various fungal infections. We investigated the association of and variants with sporotrichosis in a Chinese population and revealed one rare heterozygous mutation in a disseminated cutaneous patient without immunosuppressive conditions (, p.156_159dupCHNH). We also found that sporotrichosis patients had decreased levels of MBL and MASP-2 in their serum samples compared with controls. Our findings linked, for the first time, deficiencies with susceptibility to sp.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. López-Romero E, Reyes-Montes Mdel R, Pérez-Torres A, Ruiz-Baca E, Villagómez-Castro JC, Mora-Montes HM, Flores-Carreón A, Toriello C, 2011. Sporothrix schenckii complex and sporotrichosis, an emerging health problem. Future Microbiol 6: 85102.
    [Google Scholar]
  2. Carvalho A, Cunha C, Pasqualotto AC, Pitzurra L, Denning DW, Romani L, 2010. Genetic variability of innate immunity impacts human susceptibility to fungal diseases. Int J Infect Dis 14: 460468.
    [Google Scholar]
  3. Holmberg V, Onkamo P, Lahtela E, Lahermo P, Bedu-Addo G, 2012. Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria. Malar J 11: 61.
    [Google Scholar]
  4. Wallis R, Dodds AW, Mitchell DA, Sim RB, Reid KB, Schwaeble WJ, 2007. Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway. J Biol Chem 282: 78447851.
    [Google Scholar]
  5. Fernández-Ruiz M, Giménez E, Lora D, Aguado JM, Pascual M, Manuel O, 2019. Impact of MBL2 gene polymorphisms on the risk of infection in solid organ transplant recipients: a systematic review and meta-analysis. Am J Transplant 19: 10721085.
    [Google Scholar]
  6. Kalia N, Singh J, Sharma S, Kaur M, 2019. SNPs in 3′-UTR region of MBL2 increases susceptibility to recurrent vulvovaginal infections by altering sMBL levels. Immunobiology 224: 4249.
    [Google Scholar]
  7. Beltrame MH, Boldt AB, Catarino SJ, Mendes HC, Boschmann SE, Goeldner I, Messias-Reason I, 2015. MBL-associated serine proteases (MASPs) and infectious diseases. Mol Immunol 67: 85100.
    [Google Scholar]
  8. Thiel S, Kolev M, Degn S, Steffensen R, Hansen AG, Ruseva M, Jensenius JC, 2009. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. J Immunol 182: 29392947.
    [Google Scholar]
  9. Thiel S, Steffensen R, Christensen I, Ip WK, Lau Y, Reason I, Eiberg H, Gadjeva M, Ruseva M, Jensenius JC, 2007. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun 8: 154163.
    [Google Scholar]

Data & Media loading...

  • Received : 21 Jun 2019
  • Accepted : 20 Aug 2019
  • Published online : 23 Sep 2019
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error