1921
Volume 101, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

India accounts for approximately half of the global cases, but information as to the presence of chloroquine (CQ) resistance is scarce. In an observational study in Mangaluru, south-western India, of 116 vivax malaria patients analyzed, 89.5% (102/114) had cleared parasitemia on days two or three of CQ treatment. Two remaining patients presented on days four and five without parasitemia. One hundred eight isolates of these 116 patients were successfully sequenced for polymorphisms. Eight non-synonymous polymorphisms but no wild-type isolate were detected. Ten haplotypes were observed with mutations T958M and F1076L occurring in all isolates, whereas the candidate CQ resistance marker Y976F was present in one isolate only. polymorphisms were not associated with early parasite clearance. The high proportion of early parasite clearance and the virtual absence of Y976F and of sextuple mutants suggest that CQ in the study area is still sufficiently effective. However, the abundance of mutations in the local parasite population warrants monitoring.

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  • Received : 22 Mar 2019
  • Accepted : 21 May 2019
  • Published online : 17 Jun 2019
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