1921
Volume 101, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract.

Most deaths in tuberculous meningitis occur in the early part of the illness. We assessed the determinants of early deaths, occurring within 2 months of intensive therapy. We prospectively included consecutive newly diagnosed adults with HIV-negative tuberculous meningitis. Patients were given WHO-recommended antituberculosis treatment and were followed up for 9 months. We enrolled 152 patients. A total of 26 deaths were recorded during 2 months. The logistic regression analysis revealed that papilledema ( = 0.029, odds ratio (OR) = 4.8 [1.2–19.8]), increasing age ( = 0.001, OR = 1.07 [1.03–1.1]), stage-III disease (Glasgow coma scale score ≤ 10; = 0.01, OR = 4.2 [1.4–12.3]), and hydrocephalus ( = 0.003, OR = 8.4 [2.1–33.6]) were independently associated with death. In addition, cerebral infarcts ( = 0.012, OR = 5.6 [1.5–21.3]), paraparesis ( = 0.004, OR = 8.8 [2.02–38.1]), and age ( = 0.005, OR = 1.05 [1.02–1.09]) were associated with poor functional outcome. In conclusion, disease severity predicts early deaths in tuberculous meningitis.

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  • Received : 31 Jan 2019
  • Accepted : 21 May 2019
  • Published online : 24 Jun 2019

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