Volume 101, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Although human infections of have been found throughout Southeast Asia, most cases originated from Malaysian Borneo. In Thailand, malaria was considered extremely rare. However, during October 2017–September 2018, there was a surge in the number of reported cases. Here, a series of six cases of malaria found during this period in Songkhla and Narathiwat provinces of southern Thailand are presented. All cases were confirmed by polymerase chain reaction. The unprecedented case number in the affected area is a warning sign of an increasing burden in the south of Thailand.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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  1. White NJ, , 2008. Plasmodium knowlesi: the fifth human malaria parasite. Clin Infect Dis 46: 172173. [Google Scholar]
  2. Singh B, Daneshvar C, , 2013. Human infections and detection of Plasmodium knowlesi. Clin Microbiol Rev 26: 165. [Google Scholar]
  3. Abeyasinghe R, , 2016. Plasmodium knowlesi Current Status and the Request for Review by an Evidence Review Group Committee. Malaria Policy Advisory Committee. Geneva, Switzerland: World Health Organization. [Google Scholar]
  4. Marchand RP, Culleton R, Maeno Y, Quang NT, Nakazawa S, , 2011. Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among humans and Anopheles dirus mosquitoes, southern Vietnam. Emerg Infect Dis 17: 12321239. [Google Scholar]
  5. Veeranoot Nissapatorn YLAL, , 2010. Plasmodium knowlesi: Old Story but New Fact in Southeast Asia. Joint International Tropical Medicine Meeting, December 1–3, 2010. Kuala Lumpur, Malaysia: Department of Parasitology, Faculty of Medicine, University of Malaya. [Google Scholar]
  6. Traipattanakul JCD, Trakulhun K, Phiboonbanakit D, Mungthin M, , 2014. A first case of Plasmodium knowlesi malaria in Phramongkutklao Hospital. J Infect Dis Antimicrob Agents 31: 91100. [Google Scholar]
  7. Bird EM, 2016. Transfusion-transmitted severe Plasmodium knowlesi malaria in a splenectomized patient with beta-thalassaemia major in Sabah, Malaysia: a case report. Malar J 15: 357. [Google Scholar]
  8. Chin W, Contacos PG, Collins WE, Jeter MH, Alpert E, , 1968. Experimental mosquito-transmission of Plasmodium knowlesi to man and monkey. Am J Trop Med Hyg 17: 355358. [Google Scholar]
  9. Chin W, Contacos PG, Coatney GR, Kimball HR, , 1965. A naturally acquired quotidian-type malaria in man transferable to monkeys. Science 149: 865. [Google Scholar]
  10. Cox-Singh J, Singh B, , 2008. Knowlesi malaria: newly emergent and of public health importance? Trends Parasitol 24: 406410. [Google Scholar]
  11. Luchavez J, Espino F, Curameng P, Espina R, Bell D, Chiodini P, Nolder D, Sutherland C, Lee K-S, Singh B, , 2008. Human infections with Plasmodium knowlesi, the Philippines. Emerg Infect Dis 14: 811813. [Google Scholar]
  12. Fan L, Lee SY, Koay E, Harkensee C, , 2013. Plasmodium knowlesi infection: a diagnostic challenge. BMJ Case Rep 2013: bcr2013009558. [Google Scholar]
  13. Eede PVD, Van HN, Van Overmeir C, Vythilingam I, Duc TN, Hung LX, Manh HN, Anné J, D’Alessandro U, Erhart A, , 2009. Human Plasmodium knowlesi infections in young children in central Vietnam. Malar J 8: 249. [Google Scholar]
  14. Iwagami M, 2018. First case of human infection with Plasmodium knowlesi in Laos. PLoS Negl Trop Dis 12: e0006244. [Google Scholar]
  15. Ghinai I, 2017. Malaria epidemiology in central Myanmar: identification of a multi-species asymptomatic reservoir of infection. Malar J 16: 16. [Google Scholar]
  16. Jongwutiwes S, Putaporntip C, Iwasaki T, Sata T, Kanbara H, , 2004. Naturally acquired Plasmodium knowlesi malaria in human, Thailand. Emerg Infect Dis 10: 22112213. [Google Scholar]
  17. Putaporntip C, Hongsrimuang T, Seethamchai S, Kobasa T, Limkittikul K, Cui L, Jongwutiwes S, , 2009. Differential prevalence of Plasmodium infections and cryptic Plasmodium knowlesi malaria in humans in Thailand. J Infect Dis 199: 11431150. [Google Scholar]
  18. Cordina CJ, Culleton R, Jones BL, Smith CC, MacConnachie AA, Coyne MJ, Alexander CL, , 2014. Plasmodium knowlesi: clinical presentation and laboratory diagnosis of the first human case in a Scottish traveler. J Travel Med 21: 357360. [Google Scholar]
  19. Froeschl G, Beissner M, Huber K, Bretzel G, Hoelscher M, Rothe C, , 2018. Plasmodium knowlesi infection in a returning German traveller from Thailand: a case report on an emerging malaria pathogen in a popular low-risk travel destination. BMC Infect Dis 18: 148. [Google Scholar]
  20. Kantele A, Marti H, Felger I, Müller D, Jokiranta TS, , 2008. Monkey malaria in a European traveler returning from Malaysia. Emerg Infect Dis 14: 14341436. [Google Scholar]
  21. Centers for Disease Control and Prevention, 2009. Simian malaria in a U.S. traveler–New York, 2008. MMWR Morb Mortal Wkly Rep 58: 229232. [Google Scholar]
  22. Kuo M-C, Chiang T-Y, Chan C-W, Tsai W-S, Ji D-D, , 2009. A case report of Simian malaria, Plasmodium knowlesi, in a Taiwanese traveler from Palawan Island, the Philippines. Taiwan Epidemiol Bull 25: 178191. [Google Scholar]
  23. Tanizaki R, 2013. First case of Plasmodium knowlesi infection in a Japanese traveller returning from Malaysia. Malar J 12: 128. [Google Scholar]
  24. Link L, Bart A, Verhaar N, van Gool T, Pronk M, Scharnhorst V, , 2012. Molecular detection of Plasmodium knowlesi in a Dutch traveler by real-time PCR. J Clin Microbiol 50: 25232524. [Google Scholar]
  25. Jongwutiwes S, Buppan P, Kosuvin R, Seethamchai S, Pattanawong U, Sirichaisinthop J, Putaporntip C, , 2011. Plasmodium knowlesi malaria in humans and macaques, Thailand. Emerg Infect Dis 17: 17991806. [Google Scholar]
  26. Sermwittayawong N, Singh B, Nishibuchi M, Sawangjaroen N, Vuddhakul V, , 2012. Human Plasmodium knowlesi infection in Ranong province, southwestern border of Thailand. Malar J 11: 36. [Google Scholar]
  27. ThaiMoPH, 2017. Thailand Malaria Elimination Program, Thailand. Ministry of Public Health, Available at: http: Accessed November 1, 2018. [Google Scholar]
  28. Yorsaeng R, Saeseu T, Chotivanich K, Felger I, Wampfler R, Cui L, Mueller I, Sattabongkot J, Nguitragool W, , 2019. Indigenous Plasmodium malariae infection in an endemic population at the Thai-Myanmar border. Am J Trop Med Hyg 100: 11641169. [Google Scholar]

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  • Received : 21 Jan 2019
  • Accepted : 29 Aug 2019
  • Published online : 07 Oct 2019

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