Volume 101, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Disseminated nontuberculous mycobacterial (NTM) infections usually occur in severely immunosuppressed patients. These infections may also occur in previously immunocompetent patients with acquired anti–interferon-gamma antibodies (anti–IFN-γ Abs). A previously healthy 33-year-old man presented with a 3-week history of cough and fever. Chest computed tomography showed air-space consolidation in the middle lobe of the right lung and enlargement of the supraclavicular, mediastinal, and hilar lymph nodes. Tissue samples obtained via mediastinoscopy showed granuloma formation with acid-fast bacteria; cultures from the tissue revealed . Accordingly, a diagnosis of disseminated disease was made. The positive control tested negative in the QuantiFERON-TB Gold In-tube test, suggesting the presence of anti–IFN-γ Abs. The ELISA test for anti–IFN-γ Abs demonstrated an increased titer. Antimycobacterial drug treatments were initiated after diagnosis. His symptoms improved over 2 months, and he remains well on outpatient management. Disseminated disease is a very rare condition suggestive of immunosuppression. Testing for anti–IFN-γ antibodies might be important in all cases of disseminated disease.


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  • Received : 15 Jan 2019
  • Accepted : 21 Aug 2019
  • Published online : 23 Sep 2019
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