1921
image of Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Leptospirosis is a zoonotic bacterial disease caused by pathogenic species of the genus . Disease incidence is known to be attributed to environmental and social conditions which promote the spread of reservoir hosts, primarily rodents. A well-being program was conducted to determine the seroprevalence and risk factors associated with leptospirosis in urban poor communities occupying low-cost flat accommodation and squatter settlements in the vicinity of Wilayah Persekutuan, Kuala Lumpur. Blood samples from a total of 532 volunteers were screened for the detection of IgG and IgM antibodies against leptospirosis using ELISA. Demographic data were collected for each participant through a questionnaire survey before blood collection. The overall seroprevalence was low (12.6%, = 67/532; 95% CI: 9.9–15.7%), with 8.1% ( = 43/532) being seropositive for anti- IgG, indicating previous infection, and 4.9% ( = 26/532) for anti- IgM, indicating current infection. Two significant factors such as host age ( 0.01) and knowledge of disease transmission ( = 0.017) significantly influenced the presence of anti- IgM, whereas the detection of anti-IgG indicated the presence of clean drinking water sources ( = 0.043). Despite the low prevalence, the transmission of leptospirosis does occur among urban poor communities, suggesting the need for undertaking public awareness programs.

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/content/journals/10.4269/ajtmh.19-0003
2019-10-14
2019-11-22
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.19-0003
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  • Received : 02 Jan 2019
  • Accepted : 25 Jun 2019
  • Published online : 14 Oct 2019
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