1921
Volume 101, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract.

The discovery and characterization of novel parasite antigens to improve the diagnosis of by serological methods and for accurate and rapid follow-up of treatment efficiency are still needed. TcTASV is a –specific multigene family, whose products are expressed on the parasite stages present in the vertebrate host. In a previous work, a mix of antigens from subfamilies TcTASV-A and TcTASV-C (Mix A + C) was sensitive and specific to identify dogs with active infection of high epidemiological relevance. Here, TcTASV-A and TcTASV-C were assayed separately as well as together (Mix A + C) in an ELISA format on human samples. The Mix A + C presented moderate sensitivity (78%) but high diagnostic accuracy with a 100% of specificity, evaluated on healthy, leishmaniasic, and infected patients. Moreover, antibody levels of pediatric patients showed—2 years posttreatment—diminished reactivity against the Mix A + C ( < 0.0001), pointing TcTASV antigens as promising tools for treatment follow-up.

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  • Received : 23 Nov 2018
  • Accepted : 21 Jul 2019
  • Published online : 09 Sep 2019

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