Volume 100, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Using the 20-meter shuttle run test (20mSRT) as a morbidity metric, we assessed whether infection was associated with decreased aerobic capacity in Ugandan children across a range of altitudes, either at low (∼600 m) or high (∼1,000 m) altitudes. A total of 305 children were recruited from six schools within the Buliisa District, Lake Albert, Uganda. A subset ( = 96) of these had been previously assessed and treated for schistosomiasis ± malaria 2 weeks prior. Fitness scores on the 20mSRT were translated into VO2max using a standardized equation. Unadjusted and multivariable-adjusted analyses were performed using VO2max as the primary outcome. Analysis of fitness scores from 304 children, inclusive of the subset follow-up cohort, revealed a median VO2max of 45.4 mL kg min (interquartile range: 42.9–48.0 mL kg min). Children residing at high altitudes demonstrated increased aerobic capacities (46.3 versus 44.8 mL kg min, = 0.031). The prevalence of stunting, wasting, egg patent infection, malaria, giardiasis, anemia, and fecal occult blood were 36.7%, 16.1%, 44.3%, 65.2%, 21.4%, 50.6%, and 41.2%, respectively. Median VO2max was elevated in those previously treated, compared with those newly recruited (46.3 versus 44 mL kg min, < 0.001). Multivariable-adjusted analysis revealed a strong negative association between egg patent infection and VO2max at low altitude (beta coefficient: −3.96, 95% CI: −6.56 to −137, = 0.004). This is the first study to document a negative association between infection and aerobic capacity at low altitudes using the 20mSRT.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...


Data & Media loading...

Supplemental tables and figure

  • Received : 19 Nov 2018
  • Accepted : 19 Feb 2019
  • Published online : 15 Apr 2019

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error