1921
Volume 100, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Rabies, a zoonotic viral encephalitis, continues to be a serious public health problem in India and several other countries in Asia and Africa. Survival is rarely reported in rabies, which is considered to be almost universally fatal. We report the clinical and radiological findings of eight patients with laboratory-confirmed rabies who survived the illness. With the exception of one patient who recovered with mild sequelae, all survivors had poor functional outcomes. The reported survival from rabies in recent years may reflect an increased awareness of the disease and greater access to better critical care facilities in rabies-endemic countries. Nonetheless, there is an urgent need to focus on preventive strategies to reduce the burden of this dreadful disease in rabies-endemic countries.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.18-0711
2018-11-05
2019-11-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/100/1/tpmd180711.html?itemId=/content/journals/10.4269/ajtmh.18-0711&mimeType=html&fmt=ahah

References

  1. World Health Organization, 2013. WHO Expert Consultation on Rabies: Second Report. World Health Organization Technical Report Series 982. Geneva, Switzerland: WHO. [Google Scholar]
  2. Sudarshan MK, Madhusudana SN, Mahendra BJ, Rao NS, Ashwath Narayana DH, Abdul Rahman S, Meslin FX, Lobo D, Ravikumar K, Gangaboraiah, 2007. Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey. Int J Infect Dis 11: 2935. [Google Scholar]
  3. Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J, , 2013. Human rabies: neuropathogenesis, diagnosis, and management. Lancet Neurol 12: 498513. [Google Scholar]
  4. Fooks AR, 2017. Rabies. Nat Rev Dis Primers 3: 17091. [Google Scholar]
  5. Mani RS, Madhusudana SN, Mahadevan A, Reddy V, Belludi AY, Shankar SK, , 2014. Utility of real-time Taqman PCR for antemortem and postmortem diagnosis of human rabies. J Med Virol 86: 18041812. [Google Scholar]
  6. Ashwath Narayana DH, 2014. Safety and immunogenicity study of a new purified chick embryo cell rabies vaccine Vaxirab-N (Pitman–Moore strain) manufactured in India. Hum Vaccin Immunother 10: 120125. [Google Scholar]
  7. Mani RS, Willoughby RE, Singh SK, , 2017. Human rabies in south Asia. , ed. Neglected Tropical Diseases–South Asia. Neglected Tropical Diseases. Cham, Switzerland: Springer, 349371. [Google Scholar]
  8. Mani RS, , 2016. Human rabies survivors in India: an emerging paradox? PLoS Negl Trop Dis 10: e0004774. [Google Scholar]
  9. Mani RS, Anand AM, Madhusudana SN, , 2016. Human rabies in India: an audit from a rabies diagnostic laboratory. Trop Med Int Health 21: 556563. [Google Scholar]
  10. Willoughby RE, Jr., 2015. Rabies: rare human infection–common questions. Infect Dis Clin North Am 29: 637650. [Google Scholar]
  11. Madhusudana SN, Sukumaran SM, , 2008. Antemortem diagnosis and prevention of human rabies. Ann Indian Acad Neurol 11: 312. [Google Scholar]
  12. Willoughby RE, Jr. Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, Chusid MJ, Rupprecht CE, , 2005. Survival after treatment of rabies with induction of coma. N Engl J Med 352: 25082514. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.18-0711
Loading
/content/journals/10.4269/ajtmh.18-0711
Loading

Data & Media loading...

  • Received : 29 Aug 2018
  • Accepted : 05 Oct 2018
  • Published online : 05 Nov 2018

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error