Volume 100, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 µm (95% confidence interval [CI]: 10.0–75.3, = 0.01), and 61.7 µm (95% CI: 21.5–102.0, < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.


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  1. Centers for Disease Control and Prevention, 2014. Dengue: Epidemiology. Available at: https://www.cdc.gov/dengue/epidemiology/index.html. Accessed August 7, 2017.
  2. Prayitno A, 2017. Dengue seroprevalence and force of primary infection in a representative population of urban dwelling Indonesian children. PLoS Negl Trop Dis 11: e0005621. [Google Scholar]
  3. Ranjit S, Kissoon N, , 2011. Dengue hemorrhagic fever and shock syndromes. Pediatr Crit Care Med 12: 90100. [Google Scholar]
  4. Burgner D, Liu R, Wake M, Uiterwaal CSP, , 2015. Do childhood infections contribute to adult cardiometabolic diseases? Pediatr Infect Dis J 34: 12531255. [Google Scholar]
  5. Idris NS, Grobbee DE, Burgner D, Cheung MMH, Kurniati N, Uiterwaal CSPM, , 2016. Effects of paediatric HIV infection on childhood vasculature. Eur Heart J 37: 36103616. [Google Scholar]
  6. Burgner DP, Cooper MN, Moore HC, Stanley FJ, Thompson PL, De Klerk NH, Carter KW, , 2015. Childhood hospitalisation with infection and cardiovascular disease in early-mid adulthood: a longitudinal population-based study. PLoS One 10: e0125342. [Google Scholar]
  7. Leentjens J, Bekkering S, Joosten LAB, Netea MG, Burgner DP, Riksen NP, , 2018. Trained innate immunity as a novel mechanism linking infection and the development of atherosclerosis. Circ Res 122: 664669. [Google Scholar]
  8. Cardier JE, Rivas B, Romano E, Rothman AL, Perez-Perez C, Ochoa M, Caceres AM, Cardier M, Guevara N, Giovannetti R, , 2006. Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells. Endothel J Endothel Cell Res 13: 335340. [Google Scholar]
  9. Evelein AMV, Geerts CC, Bots ML, Van Der Ent CK, Grobbee DE, Uiterwaal CSPM, , 2012. Parental blood pressure is related to vascular properties of their 5-year-old offspring. Am J Hypertens 25: 907913. [Google Scholar]
  10. Paini A, Boutouyrie P, Calvet D, Zidi M, Agabiti-Rosei E, Laurent S, , 2007. Multiaxial mechanical characteristics of carotid plaque: analysis by multiarray echotracking system. Stroke 38: 117123. [Google Scholar]
  11. Cicchetti D, , 1994. Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instrument in psychology. Psychol Assess 6: 284290. [Google Scholar]
  12. Zulkipli MS, Dahlui M, Jamil N, Peramalah D, Wai HVC, Bulgiba A, Rampal S, , 2018. The association between obesity and dengue severity among pediatric patients: a systematic review and meta-analysis. PLoS Negl Trop Dis 12: 122. [Google Scholar]
  13. Järvisalo M, Jartti L, Näntö-Salonen K, Irjala K, Rönnemaa T, Hartiala J, Celermajer D, Raitakari O, , 2001. Increased aortic intima-media thickness a marker of preclinical atherosclerosis in high-risk children. Circulation 104: 29432947. [Google Scholar]
  14. Wang TJ, , 2011. Assessing the role of circulating, genetic, and imaging biomarkers in cardiovascular risk prediction. Circulation 123: 551565. [Google Scholar]
  15. Perez AB, Sierra B, Garcia G, Aguirre E, Babel N, Alvarez M, Sanchez L, Valdes L, Volk HD, Guzman MG, , 2010. Tumor necrosis factor-alpha, transforming growth factor-β1, and interleukin-10 gene polymorphisms: implication in protection or susceptibility to dengue hemorrhagic fever. Hum Immunol 71: 11351140. [Google Scholar]
  16. García G, 2011. Long-term persistence of clinical symptoms in dengue-infected persons and its association with immunological disorders. Int J Infect Dis 15: 3843. [Google Scholar]
  17. Choque-Chávez F, Huamaní-Fuente F, Canelo-Aybar C, , 2016. Síntomas crónicos tras episodio de dengue, una necesidad de investigación. Rev Peru Med Exp Salud Publica 33: 181182. [Google Scholar]

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  • Received : 15 Aug 2018
  • Accepted : 22 Oct 2018
  • Published online : 21 Jan 2019

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