1921
Volume 100, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Maternal infection during pregnancy can have lasting effects on neurodevelopment, but the impact of malaria in pregnancy on child neurodevelopment is unknown. We present a case of a 24-year-old gravida three woman enrolled at 14 weeks 6 days of gestation in a clinical trial evaluating malaria prevention strategies in pregnancy. She had two blood samples test positive for using loop-mediated isothermal amplification before 20 weeks of gestation. At 31 weeks 4 days of gestation, the woman presented with preterm premature rupture of membranes, and the twins were delivered by cesarean section. Twin A was 1,920 g and Twin B was 1,320 g. Both placentas tested negative for malaria by microscopy, but the placenta of Twin B had evidence of past malaria by histology. The twins’ development was assessed using the –Third Edition. At 1 year chronologic age, Twin B had lower scores across all domains (composite scores: cognitive, Twin A [100], Twin B [70]; motor, Twin A [88], Twin B [73]; language, Twin A [109], Twin B [86]). This effect persisted at 2 years chronologic age (composite scores: cognitive, Twin A [80], Twin B [60]; motor, Twin A [76], Twin B [67]; language, Twin A [77], Twin B [59]). Infant health was similar over the first 2 years of life. We report differences in neurodevelopmental outcomes in placental malaria-discordant dizygotic twins. Additional research is needed to evaluate the impact of placental malaria on neurodevelopmental complications. Trial registration number: ClinicalTrials.gov number, NCT02163447. Registered: June 2014, https://clinicaltrials.gov/ct2/show/NCT02163447.

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References

  1. Bilbo SD, Schwarz JM, , 2009. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 3: 14. [Google Scholar]
  2. Knuesel I, Chicha L, Britschgi M, Schobel SA, Bodmer M, Hellings JA, Toovey S, Prinssen EP, , 2014. Maternal immune activation and abnormal brain development across CNS disorders. Nat Rev Neurol 10: 643. [Google Scholar]
  3. Dellicour S, Tatem AJ, Guerra CA, Snow RW, Kuile FO, , 2010. Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study. PLoS Med 7: e1000221. [Google Scholar]
  4. McDonald CR, 2015. Experimental malaria in pregnancy induces neurocognitive injury in uninfected offspring via a C5a-C5a receptor dependent pathway. PLoS Pathog 11: e1005140. [Google Scholar]
  5. Kakuru A, Jagannathan P, Muhindo MK, Natureeba P, Awori P, Nakalembe M, , 2016. Dihydroartemisinin–piperaquine for the prevention of malaria in pregnancy. N Engl J Med 374: 928939. [Google Scholar]
  6. Kamya MR, 2015. Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. Am J Trop Med Hyg 92: 903912. [Google Scholar]
  7. Villar J, International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) , 2014. International standards for newborn weight, length, and head circumference by gestational age and sex: the newborn cross-sectional study of the INTERGROWTH-21st project. Lancet 384: 857868. [Google Scholar]
  8. Society for Maternal-Fetal Medicine Simpson LL, , 2013. Twin-twin transfusion syndrome. Am J Obstet Gynecol 208: 318. [Google Scholar]
  9. Zaman SS, Khan NZ, Islam S, Banu S, Dixit S, Shrout P, Durkin M, , 1990. Validity of the ‘ten questions’ for screening serious childhood disability: results from urban Bangladesh. Int J Epidemiol 19: 613620. [Google Scholar]
  10. Bayley N, , 2006. Bayley Scales of Infant and Toddler Development, 3rd edition. San Antonio, TX. [Google Scholar]
  11. Halling C, Malone FD, Breathnach FM, Stewart MC, McAuliffe FM, Morrison JJ, Dicker P, Manning F, Corcoran JD, Perinatal Ireland Research Consortium, , 2016. Neuro-developmental outcome of a large cohort of growth discordant twins. Eur J Pediatr 175: 381389. [Google Scholar]
  12. Goyen T-A, Veddovi M, Lui K, , 2003. Developmental outcome of discordant premature twins at 3 years. Early Hum Dev 73: 2737. [Google Scholar]
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  • Received : 10 Aug 2018
  • Accepted : 19 Nov 2018
  • Published online : 07 Jan 2019

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