1921
Volume 99, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Dengue is endemic in Indonesia. Here, we describe the epidemiology of dengue in the city of Yogyakarta, Central Java, as a prelude to implementation of a cluster-randomized trial of for the biocontrol of arboviral transmission. Surveillance records from 2006 to 2016 demonstrate seasonal oscillations of dengue incidence with varying magnitude. Two lines of evidence demonstrate a high force of infection; the hospitalized case burden of patients diagnosed with dengue hemorrhagic fever or dengue shock syndrome over the last decade consisted predominantly of children/adolescents, and a serosurvey of 314 healthy children aged 1–10 years found 68% possessed dengue virus–neutralizing antibodies. Finally, a mobility survey indicated children aged 1–10 years, and particularly 1–5 year-olds, spent most of their daytime hours at home. These findings inform the design of clinical trials to measure the impact of novel vector control methods such as introgression into mosquitoes, by providing baseline data on disease incidence and identifying subpopulations for recruitment into prospective studies of dengue virus infection and disease. The mobility survey findings indicate that in cluster trials of interventions applied at the community level, young children can reasonably be expected to spend most of their exposure time, in epidemiological terms, within the treatment arm to which they were randomized.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.18-0315
2018-11-07
2018-12-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/99/5/tpmd180315.html?itemId=/content/journals/10.4269/ajtmh.18-0315&mimeType=html&fmt=ahah

References

  1. Bhatt S, 2013. The global distribution and burden of dengue. Nature 496: 504507. [Google Scholar]
  2. Stanaway JD, 2016. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013. Lancet Infect Dis 16: 712723. [Google Scholar]
  3. Sumarmo, 1987. Dengue haemorrhagic fever in Indonesia. Southeast Asian J Trop Med Public Health 18: 269274. [Google Scholar]
  4. Kementerian Kesehatan RI Indonesia, 2010. Demam berdarah dengue di Indonesia 1968–2009. Buletin Jendela Epidemiologi 2: 113. [Google Scholar]
  5. Shepard DS, Undurraga EA, Halasa YA, , 2013. Economic and disease burden of dengue in southeast Asia. PLoS Negl Trop Dis 7: e2055. [Google Scholar]
  6. Karyanti MR, Uiterwaal CSPM, Kusriastuti R, Hadinegoro SR, Rovers MM, Heesterbeek H, Hoes AW, Bruijning-Verhagen P, , 2014. The changing incidence of dengue haemorrhagic fever in Indonesia: a 45-year registry-based analysis. BMC Infect Dis 14: 412. [Google Scholar]
  7. Departemen Kesehatan RI Indonesia, 1994. Profil Kesehatan Indonesia 1993. Jakarta, Indonesia: Pusat Data Kesehatan.
  8. World Health Organization, 2016. Dengue vaccine: WHO position paper—July 2016. Wkly Epidemiol Rec 91: 349364. [Google Scholar]
  9. World Health Organization, 2016. Mosquito (Vector) Control Emergency Response and Preparedness for Zika Virus. Available at: http://www.who.int/neglected_diseases/news/mosquito_vector_control_response/en/. Accessed February 5, 2018.
  10. Wilson AL, Boelaert M, Kleinschmidt I, Pinder M, Scott TW, Tusting LS, Lindsay SW, , 2015. Evidence-based vector control? Improving the quality of vector control trials. Trends Parasitol 31: 380390. [Google Scholar]
  11. Bowman LR, Donegan S, McCall PJ, , 2016. Is dengue vector control deficient in effectiveness or evidence?: systematic review and meta-analysis. PLoS Negl Trop Dis 10: e0004551. [Google Scholar]
  12. Wolbers M, Kleinschmidt I, Simmons CP, Donnelly CA, , 2012. Considerations in the design of clinical trials to test novel entomological approaches to dengue control. PLoS Negl Trop Dis 6: e1937. [Google Scholar]
  13. Reiner RC, Jr. 2016. Quantifying the epidemiological impact of vector control on dengue. PLoS Negl Trop Dis 10: e0004588. [Google Scholar]
  14. Centre of Statistical Bureau of Yogyakarta Municipality, 2017. Yogyakarta Municipality in Figures 2017. Yogyakarta, Indonesia: Centre of Statistical Bureau of Yogyakarta Municipality.
  15. World Health Organization, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Geneva, Switzerland: WHO.
  16. Bennett S, Woods T, Liyanage WM, Smith DL, , 1991. A simplified general method for cluster-sample surveys of health in developing countries. World Health Stat Q 44: 98106. [Google Scholar]
  17. Timiryasova TM, Bonaparte MI, Luo P, Zedar R, Hu BT, Hildreth SW, , 2013. Optimization and validation of a plaque reduction neutralization test for the detection of neutralizing antibodies to four serotypes of dengue virus used in support of dengue vaccine development. Am J Trop Med Hyg 88: 962970. [Google Scholar]
  18. Castillo KC, Körbl B, Stewart A, Gonzalez JF, Ponce F, , 2011. Application of spatial analysis to the examination of dengue fever in Guayaquil, Ecuador. Procedia Environ Sci 7: 188193. [Google Scholar]
  19. Cuong HQ, 2016. Synchrony of dengue incidence in Ho Chi Minh City and Bangkok. PLoS Negl Trop Dis 10: e0005188. [Google Scholar]
  20. Cuong HQ, Vu NT, Cazelles B, Boni MF, Thai KT, Rabaa MA, Quang LC, Simmons CP, Huu TN, Anders KL, , 2013. Spatiotemporal dynamics of dengue epidemics, southern Vietnam. Emerg Infect Dis 19: 945953. [Google Scholar]
  21. Cummings DA, Irizarry RA, Huang NE, Endy TP, Nisalak A, Ungchusak K, Burke DS, , 2004. Travelling waves in the occurrence of dengue haemorrhagic fever in Thailand. Nature 427: 344347. [Google Scholar]
  22. Salje H, 2012. Revealing the microscale spatial signature of dengue transmission and immunity in an urban population. Proc Natl Acad Sci USA 109: 95359538. [Google Scholar]
  23. Mammen MP, 2008. Spatial and temporal clustering of dengue virus transmission in Thai villages. PLoS Med 5: e205. [Google Scholar]
  24. Yoon IK, 2012. Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. PLoS Negl Trop Dis 6: e1730. [Google Scholar]
  25. Wahyono TYM, Nealon J, Beucher S, Prayitno A, Moureau A, Nawawi S, Thabrany H, Nadjib M, , 2017. Indonesian dengue burden estimates: review of evidence by an expert panel. Epidemiol Infect 145: 23242329. [Google Scholar]
  26. Nealon J, 2016. Symptomatic dengue disease in five southeast Asian countries: epidemiological evidence from a dengue vaccine trial. PLoS Negl Trop Dis 10: e0004918. [Google Scholar]
  27. Undurraga EA, Halasa YA, Shepard DS, , 2013. Use of expansion factors to estimate the burden of dengue in southeast Asia: a systematic analysis. PLoS Negl Trop Dis 7: e2056. [Google Scholar]
  28. Rasic G, Endersby-Harshman N, Tantowijoyo W, Goundar A, White V, Yang Q, Filipovic I, Johnson P, Hoffmann AA, Arguni E, , 2015. Aedes aegypti has spatially structured and seasonally stable populations in Yogyakarta, Indonesia. Parasit Vectors 8: 610. [Google Scholar]
  29. Prayitno A, 2017. Dengue seroprevalence and force of primary infection in a representative population of urban dwelling Indonesian children. PLoS Negl Trop Dis 11: e0005621. [Google Scholar]
  30. Kwong JC, Druce JD, Leder K, , 2013. Zika virus infection acquired during brief travel to Indonesia. Am J Trop Med Hyg 89: 516517. [Google Scholar]
  31. Perkasa A, 2016. Isolation of Zika virus from febrile patient, Indonesia. Emerg Infect Dis 22: 924925. [Google Scholar]
  32. Anders KL, 2018. The AWED trial (Applying Wolbachia to Eliminate Dengue) to assess the efficacy of Wolbachia-infected mosquito deployments to reduce dengue incidence in Yogyakarta, Indonesia: study protocol for a cluster randomised controlled trial. Trials 19: 302. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.18-0315
Loading
/content/journals/10.4269/ajtmh.18-0315
Loading

Data & Media loading...

  • Received : 13 Apr 2018
  • Accepted : 19 Jul 2018

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error