1921
Volume 99, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Antibodies directed against malaria parasites are easy and inexpensive to measure but remain an underused surveillance tool because of a lack of consensus on what to measure and how to interpret results. High-throughput screening of antibodies from well-characterized cohorts offers a means to substantially improve existing assays by rationally choosing the most informative sets of responses and analytical methods. Recent data suggest that high-resolution information on malaria exposure can be obtained from a small number of samples by measuring a handful of properly chosen antibody responses. In this review, we discuss how standardized multi-antibody assays can be developed and efficiently integrated into existing surveillance activities, with potential to greatly augment the breadth and quality of information available to direct and monitor malaria control and elimination efforts.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2018-11-07
2018-11-20
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References

  1. Tusting LS, Bousema T, Smith DL, Drakeley C, , 2014. Chapter three—measuring changes in Plasmodium falciparum transmission: precision, accuracy and costs of metrics. Rollinson D, ed. Advances in Parasitology, Vol. 84. Academic Press, 151–208. Available at: http://www.sciencedirect.com/science/article/pii/B978012800099100003X. Accessed August 11, 2014.
  2. Lindblade KA, Steinhardt L, Samuels A, Kachur SP, Slutsker L, , 2013. The silent threat: asymptomatic parasitemia and malaria transmission. Expert Rev Anti Infect Ther 11: 623639.
  3. Gething PW, Patil AP, Smith DL, Guerra CA, Elyazar IR, Johnston GL, Tatem AJ, Hay SI, , 2011. A new world malaria map: Plasmodium falciparum endemicity in 2010. Malar J 10: 378.
  4. Hay SI, Smith DL, Snow RW, , 2008. Measuring malaria endemicity from intense to interrupted transmission. Lancet Infect Dis 8: 369378.
  5. Metcalf CJE, Farrar J, Cutts FT, Basta NE, Graham AL, Lessler J, Ferguson NM, Burke DS, Grenfell BT, , 2016. Use of serological surveys to generate key insights into the changing global landscape of infectious disease. Lancet Lond Engl 388: 728730.
  6. Grenfell BT, Anderson RM, , 1985. The estimation of age-related rates of infection from case notifications and serological data. Epidemiol Amp Infect 95: 419436.
  7. Muench H, , 1934. Derivation of rates from summation data by the catalytic curve. J Am Stat Assoc 29: 2538.
  8. Drakeley CJ, 2005. Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure. Proc Natl Acad Sci USA 102: 51085113.
  9. Corran P, Coleman P, Riley E, Drakeley C, , 2007. Serology: a robust indicator of malaria transmission intensity? Trends Parasitol 23: 575582.
  10. Cook J, Kleinschmidt I, Schwabe C, Nseng G, Bousema T, Corran PH, Riley EM, Drakeley CJ, , 2011. Serological markers suggest heterogeneity of effectiveness of malaria control interventions on Bioko Island, Equatorial Guinea. PLoS One 6: e25137.
  11. Sepúlveda N, Paulino CD, Drakeley C, , 2015. Sample size and power calculations for detecting changes in malaria transmission using antibody seroconversion rate. Malar J 14: 529.
  12. Arnold BF, van der Laan MJ, Hubbard AE, Steel C, Kubofcik J, Hamlin KL, Moss DM, Nutman TB, Priest JW, Lammie PJ, , 2017. Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. PLoS Negl Trop Dis 11: e0005616.
  13. Pothin E, Ferguson NM, Drakeley CJ, Ghani AC, , 2016. Estimating malaria transmission intensity from Plasmodium falciparum serological data using antibody density models. Malar J 15: 79.
  14. Yman V, White MT, Rono J, Arcà B, Osier FH, Troye-Blomberg M, Boström S, Ronca R, Rooth I, Färnert A, , 2016. Antibody acquisition models: a new tool for serological surveillance of malaria transmission intensity. Sci Rep 6: 19472.
  15. Baum E, Badu K, Molina DM, Liang X, Felgner PL, Yan G, , 2013. Protein microarray analysis of antibody responses to Plasmodium falciparum in western Kenyan highland sites with differing transmission levels. PLoS One 8: e82246.
  16. Ondigo BN, Hodges JS, Ireland KF, Magak NG, Lanar DE, Dutta S, Narum DL, Park GS, Ofulla AV, John CC, , 2014. Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens. J Infect Dis 210: 11231132.
  17. King CL, Davies DH, Felgner P, Baum E, Jain A, Randall A, Tetteh K, Drakeley CJ, Greenhouse B, , 2015. Biosignatures of exposure/transmission and immunity. Am J Trop Med Hyg 93 (Suppl): 1627.
  18. Longley RJ, 2017. Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. PLoS Negl Trop Dis 11: e0005888.
  19. Helb DA, 2015. Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities. Proc Natl Acad Sci USA 112: E4438E4447.
  20. Coulibaly D, 2014. Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali. Malar J 13: 374.
  21. Clark TD, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Greenhouse B, Staedke SG, Kamya MR, Dorsey G, Rosenthal PJ, , 2010. Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children. PLoS One 5: e11759.
  22. Olotu A, Fegan G, Williams TN, Sasi P, Ogada E, Bauni E, Wambua J, Marsh K, Borrmann S, Bejon P, , 2010. Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya. PLoS One 5: e15569.
  23. Kamya MR, 2015. Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. Am J Trop Med Hyg 92: 903912.
  24. Robinson LJ, 2015. Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model. PLoS Med 12: e1001891.
  25. Longley RJ, Reyes-Sandoval A, Montoya-Díaz E, Dunachie S, Kumpitak C, Nguitragool W, Mueller I, Sattabongkot J, , 2016. Acquisition and longevity of antibodies to Plasmodium vivax preerythrocytic antigens in western Thailand. Clin Vaccine Immunol 23: 117124.
  26. Mwesigwa J, 2017. Residual malaria transmission dynamics varies across the Gambia despite high coverage of control interventions. PLoS One 12: e0187059.
  27. Tran TM, 2013. An intensive longitudinal cohort study of Malian children and adults reveals no evidence of acquired immunity to Plasmodium falciparum infection. Clin Infect Dis 57: 4047.
  28. Rodriguez-Barraquer I, 2016. Quantifying heterogeneous malaria exposure and clinical protection in a cohort of Ugandan children. J Infect Dis 214: 10721080.
  29. Akpogheneta OJ, Duah NO, Tetteh KKA, Dunyo S, Lanar DE, Pinder M, Conway DJ, , 2008. Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific. Infect Immun 76: 17481755.
  30. Liu EW, Skinner J, Tran TM, Kumar K, Narum DL, Jain A, Ongoiba A, Traoré B, Felgner PL, Crompton PD, , 2018. Protein-specific features associated with variability in human antibody responses to Plasmodium falciparum Malaria antigens. Am J Trop Med Hyg 98: 5766.
  31. Crompton PD, 2010. A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proc Natl Acad Sci USA 107: 69586963.
  32. Travassos MA, 2013. Seroreactivity to Plasmodium falciparum erythrocyte membrane protein 1 intracellular domain in malaria-exposed children and adults. J Infect Dis 208: 15141519.
  33. Xu GJ, 2015. Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science 348: aaa0698.
  34. Yeka A, Nankabirwa J, Mpimbaza A, Kigozi R, Arinaitwe E, Drakeley C, Greenhouse B, Kamya MR, Dorsey G, Staedke SG, , 2015. Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda. PLoS One 10: e0118901.
  35. Bødker R, Akida J, Shayo D, Kisinza W, Msangeni HA, Pedersen EM, Lindsay SW, , 2003. Relationship between altitude and intensity of malaria transmission in the Usambara Mountains, Tanzania. J Med Entomol 40: 706717.
  36. Drakeley CJ, Carneiro I, Reyburn H, Malima R, Lusingu JPA, Cox J, Theander TG, Nkya WMMM, Lemnge MM, Riley EM, , 2005. Altitude-dependent and -independent variations in Plasmodium falciparum prevalence in northeastern Tanzania. J Infect Dis 191: 15891598.
  37. Mbogo CN, Snow RW, Khamala CP, Kabiru EW, Ouma JH, Githure JI, Marsh K, Beier JC, , 1995. Relationships between Plasmodium falciparum transmission by vector populations and the incidence of severe disease at nine sites on the Kenyan coast. Am J Trop Med Hyg 52: 201206.
  38. Mwangi TW, Ross A, Snow RW, Marsh K, , 2005. Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya. J Infect Dis 191: 19321939.
  39. Oesterholt MJ, Bousema JT, Mwerinde OK, Harris C, Lushino P, Masokoto A, Mwerinde H, Mosha FW, Drakeley CJ, , 2006. Spatial and temporal variation in malaria transmission in a low endemicity area in northern Tanzania. Malar J 5: 98.
  40. Overgaard HJ, Reddy VP, Abaga S, Matias A, Reddy MR, Kulkarni V, Schwabe C, Segura L, Kleinschmidt I, Slotman MA, , 2012. Malaria transmission after five years of vector control on Bioko Island, Equatorial Guinea. Parasit Vectors 5: 253.
  41. Perraut R, Marrama L, Diouf B, Sokhna C, Tall A, Nabeth P, Trape J-F, Longacre S, Mercereau-Puijalon O, , 2005. Antibodies to the conserved C-terminal domain of the Plasmodium falciparum merozoite surface protein 1 and to the merozoite extract and their relationship with in vitro inhibitory antibodies and protection against clinical malaria in a Senegalese village. J Infect Dis 191: 264271.
  42. Stewart L, 2009. Rapid assessment of malaria transmission using age-specific sero-conversion rates. PLoS One 4: e6083.
  43. Stuckey EM, 2012. Simulation of malaria epidemiology and control in the highlands of western Kenya. Malar J 11: 357.
  44. Gerardin J, Ouédraogo AL, McCarthy KA, Eckhoff PA, Wenger EA, , 2015. Characterization of the infectious reservoir of malaria with an agent-based model calibrated to age-stratified parasite densities and infectiousness. Malar J 14: 231.
  45. White MT, Griffin JT, Akpogheneta O, Conway DJ, Koram KA, Riley EM, Ghani AC, , 2014. Dynamics of the antibody response to Plasmodium falciparum infection in African children. J Infect Dis 210: 11151122.
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  • Received : 09 Apr 2018
  • Accepted : 10 Jul 2018

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