1921
Volume 99, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We report two cases of corneal coinfection with and sp. along with the review of published literature. A 35-year-old woman and 65-year-old man presented to the institute with corneal ulcer refractory for treatment with topical antibiotics. Microbiological examination revealed the presence of cysts along with septate, hyaline fungal filaments. After emergency therapeutic penetrating keratoplasty (TPK) in both, the corneal tissue was sent for histopathologic examination, which confirmed the presence of and fungal coinfection. One patient had a recurrence of fungal infection after TPK. In subjects with a rapid progression of mycotic ulcer, coinfection with other microorganisms including should be suspected. The two cases presented here emphasize the importance of microbiology in making prompt diagnosis and appropriate management of these cases at an early stage.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.18-0158
2018-07-16
2019-11-18
Loading full text...

Full text loading...

/deliver/fulltext/14761645/99/3/tpmd180158.html?itemId=/content/journals/10.4269/ajtmh.18-0158&mimeType=html&fmt=ahah

References

  1. Gopinathan U, Garg P, Fernandes M, Sharma S, Athmanathan S, Rao GN, , 2002. The Epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in south India. Cornea 21: 555559. [Google Scholar]
  2. Sharma S, Garg P, Rao GN, , 2000. Patients characteristics, diagnosis and treatment of non-contact lens related Acanthamoeba keratitis. Br J Ophthalmol 84: 11031108. [Google Scholar]
  3. Nunes TE, Brazil NT, Fuentefria AM, Rott MB, , 2016. Acanthamoeba and Fusarium interactions: a possible problem in keratitis. Acta Trop 157: 102107. [Google Scholar]
  4. Froumis NA, Mondino BJ, Glasgow BJ, , 2001. Acanthamoeba keratitis associated with fungal keratitis. Am J Ophthalmol 131: 508509. [Google Scholar]
  5. Tien SH, Sheu MM, , 1999. Treatment of Acanthamoeba keratitis combined with fungal infection with polyhexamethylene biguanide. Kaohsiung J Med Sci 15: 665673. [Google Scholar]
  6. Slade DS, Johnson JT, Tabin G, , 2008. Acanthamoeba and fungal keratitis in a woman with a history of intacs corneal implants. Eye Contact Lens 34: 185187. [Google Scholar]
  7. Lee WB, Grossniklaus HE, Edelhauser HF, , 2010. Concurrent Acanthamoeba and Fusarium keratitis with silicone hydrogel contact lens use. Cornea 29: 210213. [Google Scholar]
  8. Lin HC, Hsiao CH, Ma DH, Yeh LK, Tan HY, Lin MY, Huang SCM, , 2009. Medical treatment for combined Fusarium and Acanthamoeba keratitis. Acta Ophthalmol 87: 199203. [Google Scholar]
  9. Lin HC, Chu PH, Kuo YH, Shen SC, , 2005. Clinical experience in managing Fusarium solani keratitis. Int J Clin Pract 59: 549554. [Google Scholar]
  10. Gopinathan U, Sharma S, Garg P, Rao GN, , 2009. Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade. Indian J Ophthalmol 57: 273279. [Google Scholar]
  11. Luna LG, , 1968. Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. New York, NY: McGraw-Hill.
  12. Bharathi MJ, Ramakrishnan R, Meenakshi R, Shivakumar C, Raj DL, , 2009. Analysis of the risk factors predisposing to fungal, bacterial & Acanthamoeba keratitis in south India. Indian J Med Res 130: 749757. [Google Scholar]
  13. Gupta N, Samantaray JC, Duggal S, Srivastava V, Dhull CS, Chaudhary U, , 2010. Acanthamoeba keratitis with Curvularia co-infection. Indian J Med Microbiol 28: 6771. [Google Scholar]
  14. Rumelt S, Cohen I, Lefter E, Rehany U, , 2001. Corneal coinfection with Scedosporium apiospermum and Acanthamoeba after sewage contaminated ocular injury. Cornea 20: 112116. [Google Scholar]
  15. Gussler JR, Miller D, Jaffe M, Alfonso EC, , 1995. Infection after radial keratotomy. Am J Ophthalmol 119: 798799. [Google Scholar]
  16. Babu K, Murthy KR, , 2007. Combined fungal and Acanthamoeba keratitis: diagnosis by in vivo confocal microscopy. Eye (Lond) 21: 271272. [Google Scholar]
  17. Hu J, Wang Y, Xie L, , 2009. Potential role of macrophages in experimental keratomycosis. Invest Ophthalmol Vis Sci 50: 20872094. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.18-0158
Loading
/content/journals/10.4269/ajtmh.18-0158
Loading

Data & Media loading...

  • Received : 21 Feb 2018
  • Accepted : 04 Jun 2018
  • Published online : 16 Jul 2018

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error