Volume 99, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Congenital malaria (CM) is uncommon in both malaria-endemic and non-endemic countries. It may be caused by any spp., although and are the more frequent etiologic agents. We report a case of delayed diagnosis of CM by in a newborn of an Eritrean . The mother developed pregnancy-related immunodepression and varicella-zoster viral infection 9 days before natural delivery; therefore, the child was admitted in the neonatal intensive care unit (NICU) to administer specific varicella-zoster immunoglobulin prophylaxis and for clinical monitoring. During the NICU stay, the newborn presented a febrile syndrome with vomiting, anemia, and thrombocytopenia. A severe malaria diagnosis was made by detecting trophozoites in the thick and thin blood smears. The infant was successfully treated with intravenous artesunate and clindamycin. Our experience suggests that malaria diagnostic tests need to be included in routine blood analyses in newborns with febrile syndrome from mothers with an epidemiologic link to malaria-endemic areas.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Coll O, Menendez C, Botet F, Dayal R, Carbonell-Estrany X, Weisman LE, Anceschi MM, Greenough A, Gibss RS, Ville Y, World Association of Perinatal Medicine Perinatal Infections Working Group; , 2008. Treatment and prevention of malaria in pregnancy and newborn. J Perinat Med 36: 1529. [Google Scholar]
  2. Piñeros-Jiménez JG, Alvarez G, Tobon A, Arboleda M, Carrero S, Blair S, , 2011. Congenital malaria in Urabá, Colombia. Malar J 10: 239. [Google Scholar]
  3. Poespoprodjo JR, Hasanuddin A, Fobia W, Sugiarto P, Kenangalem E, Lampah DA, Tjitra E, Price RN, Anstey NM, , 2010. Severe congenital malaria acquired in utero. Am J Trop Med Hyg 82: 563565. [Google Scholar]
  4. Falade C, Mokuolu O, Okafor H, Orogade A, Falade A, Adedoyin O, Oguonu T, Aisha M, Hamer AH, Callahan MV, , 2007. Epidemiology of congenital malaria in Nigeria: a multi-centre study. Trop Med Int Health 12: 12791287. [Google Scholar]
  5. Sierez JY, De Pontual L, Poliane I, Ledeur F, Haouchine D, Lachassine E, Lebras J, Gaudelus J, , 2005. Congenital malaria as a result of Plasmodium malariae in an infant born to a HIV-seropositive woman. Trop Med 65: 477481. [Google Scholar]
  6. Akindele JA, Sowunmi A, Abohweyere AE, , 1993. Congenital malaria in a hyperendemic area: a preliminary study. Ann Trop Paediatr 13: 273276. [Google Scholar]
  7. Pasvol G, Weatherall DJ, Wilson RJ, , 1977. Effects of foetal haemoglobin on susceptibility of red cells to Plasmodium falciparum. Nature 270: 171173. [Google Scholar]
  8. Bhatia R, Rajwaniya D, Agrawal P, , 2016. Congenital malaria due to Plasmodium vivax infection in a neonate. Case Rep Pediatr 2016: 1929046. [Google Scholar]
  9. Ibhanesebhor SE, , 1995. Clinical characteristics of neonatal malaria. J Trop Pediatr 41: 330333. [Google Scholar]
  10. Oraneli BU, Okeke OC, Ubachukwu PO, , 2013. Effect of placental malaria on birth weight of babies in Nnewi, Anambra state, Nigeria. J Vector Borne Dis 50: 1317. [Google Scholar]
  11. Uneke CJ, , 2007. Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence? Parasitol Res 101: 835842. [Google Scholar]
  12. Rai P, Majumdar K, Sharma S, Chauhan R, Chandra J, , 2015. Congenital malaria in a neonate: case report with comprehensive review on differential diagnosis, treatment and prevention in Indian perspective. J Parasit Dis 39: 345348. [Google Scholar]
  13. Covell G, , 1950. Congenital malaria. Trop Dis Bull 47: 11471167. [Google Scholar]
  14. Ezeoke AC, Ibanga NJ, Braide EL, , 1985. Congenital malaria at University of Calabar Teaching Hospital, with reference to haemoglobin and immunoglobin. Cent Afr J Med 31: 241247. [Google Scholar]
  15. Mukhtar MY, Lesi FE, Iroha EU, Egri-Okwaji MT, Mafe AG, , 2006. Congenital malaria among inborn babies at a tertiary centre in Lagos, Nigeria. J Trop Pediatr 52: 1923. [Google Scholar]
  16. Tatura SNN, Wowor EC, Mandei JM, Wilar R, Warouw SM, Rompis J, Kalensang P, Tuda J, , 2018. Case report: severe Plasmodium vivax malaria mimicking sepsis in a neonate. Am J Trop Med Hyg 98: 656659. [Google Scholar]
  17. Del Punta V, Gulletta M, Matteelli A, Spinoni V, Regazzoli A, Castelli F, , 2010. Congenital Plasmodium vivax malaria mimicking neonatal sepsis: a case report. Malar J 9: 63. [Google Scholar]
  18. Gülas S, Özdener N, , 2016. Congenital malaria: importance of diagnosis and treatment in pregnancy. Turk J Pediatr 58: 195199. [Google Scholar]
  19. World Health Organization, 2015. Guidelines for the Treatment of Malaria, 3rd edition. Geneva, Switzerland: WHO.

Data & Media loading...

  • Received : 31 Jan 2018
  • Accepted : 16 Mar 2018
  • Published online : 16 Jul 2018

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error