1921
image of Schistosoma mansoni Mass Drug Administration Regimens and Their Effect on Morbidity among Schoolchildren over a 5-Year Period—Kenya, 2010–2015
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Schistosomiasis control programs are designed to reduce morbidity by providing mass drug administration (MDA) of praziquantel to at-risk populations. We compared morbidity markers between two cohorts of Kenyan schoolchildren that initially had high prevalence of infections. One cohort ( = 416 at year 1) received four rounds of annual MDA in a community-wide treatment (CWT) strategy. The other cohort ( = 386 at year 1) received school-based treatment (SBT) every other year over the 4-year period. We measured infection with and soil-transmitted helminths (STH) as well as subtle morbidity markers at year 1, year 3, and year 5 and compared cohorts with mixed models after controlling for age and gender. At year 5, neither overall prevalence nor the prevalence of high infection–intensity infection was significantly reduced compared with baseline in either the CWT cohort ( = 277 remaining) or the SBT cohort ( = 235 remaining). Nevertheless, by year 5, children in both cohorts demonstrated significant decreases in wasting, ultrasound-detected organomegaly, and STH infection along with significantly improved pediatric quality-of-life scores compared with year 1. Stunting did not change over time, but children who were egg–positive at year 5 had significantly more stunting than children without schistosomiasis. The only significant difference between arms at year 5 was a lower prevalence of STH infections in the CWT group.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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/content/journals/10.4269/ajtmh.18-0067
2018-06-11
2018-06-21
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.18-0067
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  • Published online : 11 Jun 2018
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