1921
Volume 98, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

transmission in Brazil was linked to a large outbreak of microcephaly but less is known about longer term anthropometric and neurological outcomes. We studied a cohort of infants born between October 31, 2015, and January 9, 2016, in a state maternity hospital, followed up for 101 ± 28 days by home visits. Microcephaly (< 2 standard deviations, Intergrowth standard) occurred in 62 of 412 (15%) births. Congenital Zika syndrome (CZS) was diagnosed in 29 patients. Among CZS patients, we observed a significant gain in anthropometric measures ( < 0.001) but no significant gain in percentile for these measures. The main neurological outcome was epilepsy, occurring in 48% of infants at a rate of 15.6 cases per 100 patient-months, frequently requiring multiple anti-seizure medications. The cumulative fatality rate was 7.4% (95% confidence interval: 2.1–23.4%). Health-care professionals should be alerted on the high risk of epilepsy and death associated with CZS in early infancy and the need to actively screen for seizures and initiate timely treatment.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.17-1020
2018-04-23
2019-05-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/98/6/tpmd171020.html?itemId=/content/journals/10.4269/ajtmh.17-1020&mimeType=html&fmt=ahah

References

  1. Franca GV, 2016. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet 388: 891897. [Google Scholar]
  2. Costa F, 2016. Emergence of congenital Zika syndrome: viewpoint from the front lines. Ann Intern Med 164: 689691. [Google Scholar]
  3. Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR, , 2016. Zika virus and birth defects–reviewing the evidence for causality. N Engl J Med 374: 19811987. [Google Scholar]
  4. Hazin AN, 2016. Computed tomographic findings in microcephaly associated with Zika virus. N Engl J Med 374: 21932195. [Google Scholar]
  5. de Paula Freitas B, de Oliveira Dias JR, Prazeres J, Sacramento GA, Ko AI, Maia M, Belfort R, Jr., 2016. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol 134: 529535. [Google Scholar]
  6. Satterfield-Nash A, 2017. Health and development at age 19–24 months of 19 children who were born with microcephaly and laboratory evidence of congenital Zika virus infection during the 2015 Zika virus outbreak—Brazil, 2017. MMWR Morb Mortal Wkly Rep 15: 13471351. [Google Scholar]
  7. Ito Y, Japanese Society for Pediatric Infectious Diseases , 2013. Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan. Pediatr Int 55: 566571. [Google Scholar]
  8. Carvalho MD, Miranda-Filho DB, van der Linden V, Sobral PF, Ramos RC, Rocha MA, Cordeiro MT, de Alencar SP, Nunes ML, , 2017. Sleep EEG patterns in infants with congenital Zika virus syndrome. Clin Neurophysiol 128: 204214. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.17-1020
Loading
/content/journals/10.4269/ajtmh.17-1020
Loading

Data & Media loading...

  • Received : 30 Dec 2017
  • Accepted : 24 Feb 2018
  • Published online : 23 Apr 2018

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error