1921
Volume 100, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Snakebite primarily affects rural subsistent farming populations in underdeveloped and developing nations. The annual number of deaths (100,000) and physical disabilities (400,000) of snakebite victims is a societal tragedy that poses a significant added socioeconomic burden to the society. Antivenom therapy is the treatment of choice for snakebite but, as testified by the continuing high rates of mortality and morbidity, too many rural tropical snakebite victims fail to access effective treatment. Here, we advocate for more basic research to better understand the pathogenesis of systemic and local envenoming and describe how research outcomes can identify novel snakebite therapeutic strategies with the potential to be more accessible and affordable to victims than current treatment.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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References

  1. Mohapatra B, Warrell DA, Suraweera W, Bhatia P, Dhingra N, Jotkar RM, Rodriguez PS, Mishra K, Whitaker R, Jha P, , 2011. Snakebite mortality in India: a nationally representative mortality survey. PLoS Negl Trop Dis 5: e1018. [Google Scholar]
  2. Habib AG, Kuznik A, Hamza M, Abdullahi MI, Chedi BA, Chippaux JP, Warrell DA, , 2015. Snakebite is under appreciated: appraisal of burden from West Africa. PLoS Negl Trop Dis 9: e0004088. [Google Scholar]
  3. Harrison R, Hargreaves A, Wagstaff SC, Faragher B, Lalloo DG, , 2009. Snake envenoming: a disease of poverty. PLoS Negl Trop Dis 3: e569. [Google Scholar]
  4. Girish KS, Kemparaju K, , 2011. Overlooked issues of snakebite management: time for strategic approach. Curr Top Med Chem 11: 24942508. [Google Scholar]
  5. WHO, 2009. Neglected Tropical Diseases: Snakebite. Available at: http://www.who.int/neglected_diseases/diseases/snakebites/en/index.html. Accessed August 12, 2009.
  6. Editorial, 2015. Snake bite-the neglected tropical disease. Lancet 386: 1110. [Google Scholar]
  7. Calmette A, , 1896. The treatment of animals poisoned with snake venom by the injection of antivenomous serum. Br Med J 2: 399400. [Google Scholar]
  8. Chung KT, Biggers CJ, , 2001. Albert Léon Charles Calmette (1863-1933) and the antituberculous BCG vaccination. Perspect Biol Med 44: 379389. [Google Scholar]
  9. Laustsen AH, 2018. Pros and cons of different therapeutic antibody formats for recombinant antivenom development. Toxicon 146: 151175. [Google Scholar]
  10. Gutiérrez JM, León G, Burnouf T, , 2011. Antivenoms for the treatment of snakebite envenomings: the road ahead. Biologicals 39: 129142. [Google Scholar]
  11. Morais JF, de Freitas MCW, Yamaguchi IK, dos Santos MC, Dias da Silva W, , 1994. Snake antivenoms from hyperimmunized horses: comparison of the antivenom activity and biological properties of their whole IgG and F (ab′)2 fragments. Toxicon 32: 725734. [Google Scholar]
  12. Ismail M, Abd-Elsalam MA, Al-Ahaidib MS, , 1998. Pharmacokinetics of 125I-labelled Walterinnesiaaegyptia venom and its specific antivenins: flash absorption and distribution of the venom and its toxin versus slow absorption and distribution of IgG, F(ab′)2 and Fab of the antivenin. Toxicon 36: 93114. [Google Scholar]
  13. Ismail M, Abd-Elsalam MA, , 1998. Pharmacokinetics of 125I-labelled IgG, F(ab′)2 and Fab fractions of scorpion and snake antivenins: merits and potential for therapeutic use. Toxicon 36: 15231528. [Google Scholar]
  14. Rojas G, Jiménez JM, Gutiérrez JM, , 1994. Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production. Toxicon 32: 351363. [Google Scholar]
  15. León G, Monge M, Rojas E, Lomonte B, Gutiérrez JM, , 2001. Comparison between IgG and F(ab')(2) polyvalent antivenoms: neutralization of systemic effects induced by Bothropsasper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions. Toxicon 39: 793801. [Google Scholar]
  16. Eursakun S, Simsiriwong P, Ratanabanangkoon K, , 2012. Studies on the fractionation of equine antivenom IgG by combinations of ammonium sulfate and caprylic acid. Toxicon 60: 10221029. [Google Scholar]
  17. Al-Abdulla I, Casewell NR, Landon J, , 2014. Single-reagent one-step procedures for the purification of ovine IgG, F(ab')2 and Fab antivenoms by caprylic acid. J Immunol Methods 402: 1522. [Google Scholar]
  18. Bénard-Valle M, Neri-Castro EE, Fry BG, Fry BG, , 2005. Antivenom research and development. , ed. Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery. Oxford, United Kingdom: Oxford University Press, 6172. [Google Scholar]
  19. WHO, 2017. Snake Antivenom Immunoglobulins. Available at: http://www.who.int/bloodproducts/snake_antivenoms/en/. Accessed September 21, 2018.
  20. Harrison RA, 2017. Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa. PLoS Negl Trop Dis 11: e0005969. [Google Scholar]
  21. Gras S, Plantefève G, Baud F, Chippaux JP, , 2012. Snakebite on the hand: lessons from two clinical cases illustrating difficulties of surgical indication. J Venom Anim Toxins Incl Trop Dis 18: 467477. [Google Scholar]
  22. De Silva HA, Ryan NM, de Silva HJ, , 2016. Adverse reactions to snake antivenom, and their prevention and treatment. Br J Clin Pharmacol 81: 446452. [Google Scholar]
  23. Daltry JC, Wüster W, Thorpe RS, , 1996. Diet and snake venom evolution. Nature 379: 537540. [Google Scholar]
  24. Daltry JC, Ponnudurai G, Shin CK, Tan NH, Thorpe RS, Wüster W, , 1996. Electrophoretic profiles and biological activities: Intraspecific variation in the venom of the Malayan pit viper (Calloselasma rhodostoma). Toxicon 34: 6779. [Google Scholar]
  25. Shashidharamurthy R, Jagadeesha DK, Girish KS, Kemparaju K, , 2002. Variations in biochemical and pharmacological properties of Indian cobra (Naja naja naja) venom due to geographical distribution. Mol Cell Biochem 229: 93101. [Google Scholar]
  26. Casewell NR, Wagstaff SC, Wüster W, Cook DA, Bolton FM, King SI, Pla D, Sanz L, Calvete JJ, Harrison RA, , 2014. Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms. Proc Natl Acad Sci U S A 111: 92059210. [Google Scholar]
  27. Amazonas DR, 2018. Molecular mechanisms underlying intraspecific variation in snake venom. J Proteomics 181: 6072. [Google Scholar]
  28. Shashidharamurthy R, Kemparaju K, , 2007. Region-specific neutralization of Indian cobra (Naja naja) venom by polyclonal antibody raised against the eastern regional venom: a comparative study of the venoms from three different geographical distributions. Int Immunopharmacol 7: 6169. [Google Scholar]
  29. Katkar GD, Sundaram MS, NaveenKumar SK, Swethakumar B, Sharma RD, Paul M, Vishalakshi GJ, Devaraja S, Girish KS, Kemparaju K, , 2016. NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction. Nat Commun 7: 11361. [Google Scholar]
  30. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A, , 2004. Neutrophil extracellular traps kill bacteria. Science 303: 15321535. [Google Scholar]
  31. Fuchs TA, Brill A, Wagner DD, , 2012. Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler Thromb Vasc Biol 32: 17771783. [Google Scholar]
  32. Robb CT, Dyrynda EA, Gray RD, Rossi AG, Smith VJ, , 2014. Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon. Nat Commun 5: 111. [Google Scholar]
  33. Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, Taylor FB, Esmon NL, Lupu F, Esmon CT, , 2009. Extracellular histones are major mediators of death in sepsis. Nat Med 15: 13181321. [Google Scholar]
  34. Kaplan MJ, Radic M, , 2012. Neutrophil extracellular traps: double-edged swords of innate immunity. J Immunol 189: 26892695. [Google Scholar]
  35. Sarratt KL, Chen H, Zutter MM, Santoro SA, Hammer DA, Kahn ML, , 2005. GPVI and α2β1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood 106: 12681277. [Google Scholar]
  36. Ishida Y, Gao JL, Murphy PM, , 2008. Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. J Immunol 180: 569579. [Google Scholar]
  37. Leitinger B, , 2011. Transmembrane collagen receptors. Annu Rev Cell Dev Biol 27: 265290. [Google Scholar]
  38. Barun P, Yoon DS, Lee JH, Lee YM, Kim DK, , 2012. Collagen I enhances functional activities of human monocyte-derived dendritic cells via discoidin domain receptor 2. Cell Immunol 278: 95102. [Google Scholar]
  39. Leitinger B, , 2014. Discoidin domain receptor functions in physiological and pathological conditions. Int Rev Cell Mol Biol 310: 3987. [Google Scholar]
  40. Kumar AH, Martin K, Turner EC, Buneker CK, Dorgham K, Deterre P, Caplice NM, , 2013. Role of CX3CR1 receptor in monocyte/macrophage driven neovascularization. PLoS One 8: e57230. [Google Scholar]
  41. Katkar GD, Sharma RD, Vishalakshi GJ, Naveenkumar SK, Madhur G, Thushara RM, Narender T, Girish KS, Kemparaju K, , 2015. Lupeol derivative mitigates Echis carinatus venom-induced tissue destruction by neutralizing venom toxins and protecting collagen and angiogenic receptors on inflammatory cells. Biochim Biophys Acta 1850: 23932409. [Google Scholar]
  42. Sharma RD, Katkar GD, Sundaram MS, Paul M, NaveenKumar SK, Swethakumar B, Hemshekhar M, Girish KS, Kemparaju K, , 2015. Oxidative stress-induced methemoglobinemia is the silent killer during snakebite: a novel and strategic neutralization by melatonin. J Pineal Res 59: 240254. [Google Scholar]
  43. SebastinSanthosh M, Hemshekhar M, Thushara RM, Devaraja S, Kemparaju K, Girish KS, , 2013. Viperarusselli venom-induced oxidative stress and hematological alterations: amelioration by crocin a dietary colorant. Cell Biochem Funct 31: 4150. [Google Scholar]
  44. Katkar GD, Sundaram MS, Hemshekhar M, Sharma DR, Santhosh MS, Sunitha K, Rangappa KS, Girish KS, Kemparaju K, , 2014. Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress. J Pineal Res 56: 295312. [Google Scholar]
  45. Sunitha K, Hemshekhar M, Thushara RM, Santhosh MS, Sundaram MS, Kemparaju K, Girish KS, , 2015. Inflammation and oxidative stress in viper bite: an insight within and beyond. Toxicon 98: 8997. [Google Scholar]
  46. Sharma RD, Katkar GD, Sundaram MS, Swethakumar B, Girish KS, Kemparaju K, , 2017. Melatonin inhibits snake venom and antivenom induced oxidative stress and augments treatment efficacy. Acta Trop 169: 1425. [Google Scholar]
  47. Zhang Y, Marcillat O, Giulivi C, Ernster L, Davies KJ, , 1990. The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J Biol Chem 265: 1633016336. [Google Scholar]
  48. Buttke TM, Sandstrom PA, , 1995. Redox regulation of programmed cell death in lymphocytes. Free Radic Res 22: 389397. [Google Scholar]
  49. Pellerin L, Magistretti PJ, , 2003. Food for thought: challenging the dogmas. J Cereb Blood Flow Metab 23: 12821286. [Google Scholar]
  50. Fadare JO, Afolabi OA, , 2012. Management of snake bite in resource-challenged setting: a review of 18 months experience in a Nigerian hospital. J Clin Med Res 4: 3943. [Google Scholar]
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  • Received : 12 Nov 2017
  • Accepted : 30 Nov 2018
  • Published online : 21 Jan 2019

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