1921
Volume 99, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Important strides have been made within the past decade toward malaria elimination in many regions, and with this progress, the feasibility of eradication is once again under discussion. If the ambitious goal of eradication is to be achieved by 2040, all species of infecting humans will need to be targeted with evidence-based and concerted interventions. In this perspective, the potential barriers to achieving global malaria elimination are discussed with respect to the related diversities in host, parasite, and vector populations. We argue that control strategies need to be reorientated from a sequential attack on each species, dominated by to one that targets all species in parallel. A set of research themes is proposed to mitigate the potential setbacks on the pathway to a malaria-free world.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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2018-07-05
2018-10-17
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References

  1. Gates B, Chambers R, , 2015. From Aspiration to Action. Available at: http://endmalaria2040.org/assets/Aspiration-to-Action.pdf. Accessed November 19, 2015.
  2. World Health Organization, 2015. Control and Elimination of Plasmodium vivax Malaria: A Technical Brief. Geneva, Switzerland: WHO. Available at: http://www.who.int/iris/handle/10665/181162. Accessed September 8, 2016.
  3. World Health Organization, 2017. World Malaria Report 2017. Geneva, Switzerland: Global Malaria Program, WHO.
  4. Pampana EJ, , 1958. Unexpected Cost Increases of Malaria Eradication Programmes. Geneva, Switzerland: World Health Organization. Available at: http://www.who.int/iris/handle/10665/64589. Accessed August 25, 2017.
  5. Howes RE, 2015. Plasmodium vivax transmission in Africa. PLoS Negl Trop Dis 9: e0004222.
  6. Mueller I, Galinski MR, Baird JK, Carlton JM, Kochar DK, Alonso PL, del Portillo HA, , 2009. Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite. Lancet Infect Dis 9: 555566.
  7. Barber BE, William T, Grigg MJ, Menon J, Auburn S, Marfurt J, Anstey NM, Yeo TW, , 2013. A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy. Clin Infect Dis 56: 383397.
  8. Hwang J, Cullen K, Kachur SP, Arguin PM, Baird JK, , 2014. Severe morbidity and mortality risk from malaria in the United States, 1985–2011. Open Forum Infect Dis 1: ofu034.
  9. Dowdle WR, Hopkins D, , 1998. The Eradication of Infectious Diseases, Vol. 24. Chichester, United Kingdom: John Wiley & Sons.
  10. Tanner M, 2015. Malaria eradication and elimination: views on how to translate a vision into reality. BMC Med 13: 167.
  11. Roucher C, Rogier C, Sokhna C, Tall A, Trape J-F, , 2014. A 20-year longitudinal study of Plasmodium ovale and Plasmodium malariae prevalence and morbidity in a West African population. PLoS One 9: e87169.
  12. Howes RE, Battle KE, Mendis KN, Smith DL, Cibulskis RE, Baird JK, Hay SI, , 2016. Global epidemiology of Plasmodium vivax. Am J Trop Med Hyg 95 (6 Suppl): 1534.
  13. Bruce-Chwatt LJ, , 1965. Malaria research for malaria eradication. Trans R Soc Trop Med Hyg 59: 105144.
  14. Arita I, Jezek Z, Khodakevich L, Ruti K, , 1985. Human monkeypox: a newly emerged orthopoxvirus zoonosis in the tropical rain forests of Africa. Am J Trop Med Hyg 34: 781789.
  15. Eberhard ML, 2014. The peculiar epidemiology of dracunculiasis in Chad. Am J Trop Med Hyg 90: 6170.
  16. World Health Organization, 2015. World Malaria Report 2015. Geneva, Switzerland: WHO. Available at: http://www.who.int/malaria/publications/world-malaria-report-2015/report/en/. Accessed December 9, 2015.
  17. Sattabongkot J, Tsuboi T, Zollner GE, Sirichaisinthop J, Cui L, , 2004. Plasmodium vivax transmission: chances for control? Trends Parasitol 20: 192198.
  18. Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM, , 2007. Vivax malaria: neglected and not benign. Am J Trop Med Hyg 77 (6 Suppl): 7987.
  19. Anstey NM, Douglas NM, Poespoprodjo JR, Price RN, , 2012. Plasmodium vivax: clinical spectrum, risk factors and pathogenesis. Hay SI, Price RN, Baird JK, eds. Advances in Parasitology, Vol. 80. Oxford, United Kingdom: Academic Press, 151–201. Available at: http://www.sciencedirect.com/science/article/pii/B9780123979001000037. Accessed September 28, 2014.
  20. Price RN, Douglas NM, Anstey NM, , 2009. New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance. Curr Opin Infect Dis 22: 430435.
  21. Camargo-Ayala PA, Cubides JR, Niño CH, Camargo M, Rodríguez-Celis CA, Quiñones T, Sánchez-Suárez L, Patarroyo ME, Patarroyo MA, , 2016. High Plasmodium malariae prevalence in an endemic area of the Colombian Amazon region. PLoS One 11: e0159968.
  22. Douglas NM, Lampah DA, Kenangalem E, Simpson JA, Poespoprodjo JR, Sugiarto P, Anstey NM, Price RN, , 2013. Major burden of severe anemia from non-falciparum malaria species in southern Papua: a hospital-based surveillance study. PLoS Med 10: e1001575.
  23. Langford S, Douglas NM, Lampah DA, Simpson JA, Kenangalem E, Sugiarto P, Anstey NM, Poespoprodjo JR, Price RN, , 2015. Plasmodium malariae infection associated with a high burden of anemia: a hospital-based surveillance study. PLoS Negl Trop Dis 9: e0004195.
  24. Leoni S, Buonfrate D, Angheben A, Gobbi F, Bisoffi Z, , 2015. The hyper-reactive malarial splenomegaly: a systematic review of the literature. Malar J 14: 185.
  25. Collins WE, Jeffery GM, , 2007. Plasmodium malariae: parasite and disease. Clin Microbiol Rev 20: 579592.
  26. Sutherland CJ, , 2016. Persistent parasitism: the adaptive biology of malariae and ovale malaria. Trends Parasitol 32: 808819.
  27. Cox-Singh J, 2010. Severe malaria—a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. Malar J 9: 10.
  28. Singh B, Kim Sung L, Matusop A, Radhakrishnan A, Shamsul SSG, Cox-Singh J, Thomas A, Conway DJ, , 2004. A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet 363: 10171024.
  29. Prugnolle F, 2013. Diversity, host switching and evolution of Plasmodium vivax infecting African great apes. Proc Natl Acad Sci USA 110: 81238128.
  30. Costa DC, da Cunha VP, de Assis GMP, de Souza Junior JC, Hirano ZMB, de Arruda ME, Kano FS, Carvalho LH, de Brito CFA, , 2014. Plasmodium simium/Plasmodium vivax infections in southern brown howler monkeys from the Atlantic Forest. Mem Inst Oswaldo Cruz 109: 641653.
  31. Brasil P, 2017. Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: a molecular epidemiological investigation. Lancet Glob Health 5: e1038e1046.
  32. Lim CS, Tazi L, Ayala FJ, , 2005. Plasmodium vivax: recent world expansion and genetic identity to Plasmodium simium. Proc Natl Acad Sci USA 102: 1552315528.
  33. Lalremruata A, Magris M, Vivas-Martínez S, Koehler M, Esen M, Kempaiah P, Jeyaraj S, Perkins DJ, Mordmüller B, Metzger WG, , 2015. Natural infection of Plasmodium brasilianum in humans: man and monkey share quartan malaria parasites in the Venezuelan Amazon. EBioMedicine 2: 11861192.
  34. Kaiser M, 2010. Wild chimpanzees infected with 5 Plasmodium species. Emerg Infect Dis 16: 19561959.
  35. Bruce-Chwatt LJ, , 1968. Malaria zoonosis in relation to malaria eradication. Trop Geogr Med 20: 5087.
  36. Contacos PG, , 1970. Primate malarias: man and monkeys. J Wildl Dis 6: 323328.
  37. World Health Organization, Global Malaria Programme, 2007. Malaria Elimination: A Field Manual for Low and Moderate Endemic Countries. Geneva, Switzerland: WHO. Available at: http://apps.who.int//iris/handle/10665/43796. Accessed November 13, 2014.
  38. Steketee RW, ter Kuile F, , 2013. Single low-dose primaquine to reduce malaria transmission. Lancet Infect Dis 14: 9192.
  39. White MT, Karl S, Battle KE, Hay SI, Mueller I, Ghani AC, , 2014. Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission. eLife 3: e04692.
  40. Robinson LJ, 2015. Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model. PLoS Med 12: e1001891.
  41. Douglas NM, John GK, von Seidlein L, Anstey NM, Price RN, , 2012. Chemotherapeutic strategies for reducing transmission of Plasmodium vivax malaria. Adv Parasitol 80: 271300.
  42. Waltmann A, 2015. High rates of asymptomatic, sub-microscopic Plasmodium vivax infection and disappearing Plasmodium falciparum malaria in an area of low transmission in Solomon Islands. PLoS Negl Trop Dis 9: e0003758.
  43. Kaneko A, 2014. Characteristic age distribution of Plasmodium vivax infections after malaria elimination on Aneityum Island, Vanuatu. Infect Immun 82: 243252.
  44. Danis K, Baka A, Lenglet A, Van Bortel W, Terzaki I, Tseroni M, Detsis M, Papanikolaou E, Balaska A, Gewehr S, , 2011. Autochthonous Plasmodium vivax malaria in Greece, 2011. Euro Surveill 16: 20.
  45. Iwagami M, Hwang S-Y, Kim S-H, Park S-J, Lee G-Y, Matsumoto-Takahashi ELA, Kho W-G, Kano S, , 2013. Microsatellite DNA analysis revealed a drastic genetic change of Plasmodium vivax population in the Republic of Korea during 2002 and 2003. PLoS Negl Trop Dis 7: e2522.
  46. Markus MB, , 2017. Malaria eradication and the hidden parasite reservoir. Trends Parasitol 33: 492495.
  47. Daskova NG, Rasnicyn SP, , 1982. Review of data on susceptibility of mosquitos in the USSR to imported strains of malaria parasites. Bull World Health Organ 60: 893897.
  48. Bayoh MN, Mathias DK, Odiere MR, Mutuku FM, Kamau L, Gimnig JE, Vulule JM, Hawley WA, Hamel MJ, Walker ED, , 2010. Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya. Malar J 9: 62.
  49. da Silva-Nunes M, Moreno M, Conn JE, Gamboa D, Abeles S, Vinetz JM, Ferreira MU, , 2012. Amazonian malaria: asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies. Acta Trop 121: 281291.
  50. Smithuis 2013. Entomological determinants of insecticide-treated bed net effectiveness in western Myanmar. Malar J 12: 364.
  51. Dolan G, Ter Kuile FO, Jacoutot V, White NJ, Luxemburger C, Malankirii L, Chongsuphajaisiddhi T, Nosten F, , 1993. Bed nets for the prevention of malaria and anaemia in pregnancy. Trans R Soc Trop Med Hyg 87: 620626.
  52. Lengeler C, , 2004. Insecticide-treated bed nets and curtains for preventing malaria. Cochrane Database Syst Rev 2: CD000363.
  53. Smithuis FM, 2013. The effect of insecticide-treated bed nets on the incidence and prevalence of malaria in children in an area of unstable seasonal transmission in western Myanmar. Malar J 12: 1.
  54. Grietens KP, Nguyen Xuan X, Muela Ribera J, Ngo Duc T, van Bortel W, Truong Ba N, Van KP, Le Xuan H, D’Alessandro U, Erhart A, , 2012. Social determinants of long lasting insecticidal hammock-use among the Ra-glai ethnic minority in Vietnam: implications for forest malaria control. PLoS One 7: e29991.
  55. Chen-Hussey V, Carneiro I, Keomanila H, Gray R, Bannavong S, Phanalasy S, Lindsay SW, , 2013. Can topical insect repellents reduce malaria? A cluster-randomised controlled trial of the insect repellent n,n-diethyl-m-toluamide (DEET) in Lao PDR. PLoS One 8: e70664.
  56. Lobo NF, 2016. Unexpected diversity of Anopheles species in eastern Zambia: implications for evaluating vector behavior and interventions using molecular tools. Sci Rep 5: 17952.
  57. Stevenson J, St. Laurent B, Lobo NF, Cooke MK, Kahindi SC, Oriango RM, Harbach RE, Cox J, Drakeley C, , 2012. Novel vectors of malaria parasite in the Western Highlands of Kenya. Emerg Infect Dis 18: 15471549.
  58. Stevenson JC, Norris DE, , 2016. Implicating cryptic and novel Anophelines as malaria vectors in Africa. Insects 8: 1.
  59. Faulde MK, Rueda LM, Khaireh BA, , 2014. First record of the Asian malaria vector Anopheles stephensi and its possible role in the resurgence of malaria in Djibouti, Horn of Africa. Acta Trop 139: 3943.
  60. Gunathilaka N, Fernando T, Hapugoda M, Wickremasinghe R, Wijeyerathne P, Abeyewickreme W, , 2013. Anopheles culicifacies breeding in polluted water bodies in Trincomalee district of Sri Lanka. Malar J 12: 1.
  61. Ramasamy R, Surendran SN, , 2016. Mosquito vectors developing in atypical anthropogenic habitats: global overview of recent observations, mechanisms and impact on disease transmission. J Vector Borne Dis 53: 91.
  62. McArthur J, , 1947. The transmission of malaria in Borneo. Trans R Soc Trop Med Hyg 40: 537558.
  63. Schapira A, Boutsika K, , 2012. Malaria ecotypes and stratification. Advances in Parasitology, Rollinson D, Hay SI, eds. Vol. 78. London: Academic Press, 97–167. Available at: http://linkinghub.elsevier.com/retrieve/pii/B9780123943033000013. Accessed September 12, 2012.
  64. Tusting LS, Ippolito MM, Willey BA, Kleinschmidt I, Dorsey G, Gosling RD, Lindsay SW, , 2015. The evidence for improving housing to reduce malaria: a systematic review and meta-analysis. Malar J 14: 209.
  65. Boyd MF, , 1949. Malariology: A Comprehensive Survey of All Aspects of This Group of Diseases from a Global Standpoint, 1st edition. Philadelphia and London: Saunders.
  66. Keiser J, Singer BH, Utzinger J, , 2005. Reducing the burden of malaria in different eco-epidemiological settings with environmental management: a systematic review. Lancet Infect Dis 5: 695708.
  67. Chen I, Clarke SE, Gosling R, Hamainza B, Killeen G, Magill A, O’Meara W, Price RN, Riley EM, , 2016. “Asymptomatic” malaria: a chronic and debilitating infection that should be treated. PLoS Med 13: e1001942.
  68. Koepfli C, 2015. Blood-stage parasitaemia and age determine Plasmodium falciparum and P. vivax gametocytaemia in Papua New Guinea. PLoS One 10: e0126747.
  69. Moreira CM, Abo-Shehada M, Price RN, Drakeley CJ, , 2015. A systematic review of sub-microscopic Plasmodium vivax infection. Malar J 14: 360.
  70. Imwong M, 2016. Numerical distributions of parasite densities during asymptomatic malaria. J Infect Dis 213: 13221329.
  71. Gamage-Mendis AC, Rajakaruna J, Carter R, Mendis KN, , 1991. Infectious reservoir of Plasmodium vivax and Plasmodium falciparum malaria in an endemic region of Sri Lanka. Am J Trop Med Hyg 45: 479487.
  72. Lover AA, Coker RJ, , 2013. Quantifying effect of geographic location on epidemiology of Plasmodium vivax malaria. Emerg Infect Dis 19: 10581065.
  73. Battle KE, 2014. Geographical variation in Plasmodium vivax relapse. Malar J 13: 144.
  74. Gunawardena S, Ferreira MU, Kapilananda GMG, Wirth DF, Karunaweera ND, , 2014. The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission. Parasitology 141: 880890.
  75. Noviyanti R, 2015. Contrasting transmission dynamics of co-endemic Plasmodium vivax and P. falciparum: implications for malaria control and elimination. PLoS Negl Trop Dis 9: e0003739.
  76. Neafsey DE, Galinsky K, Jiang RHY, Young L, Sykes SM, Saif S, Gujja S, Goldberg JM, Young S, Zeng Q, , 2012. The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nat Genet 44: 10461050.
  77. Rosanas-Urgell A, 2012. Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with southeast Asian ovalocytosis in two cohorts and a case-control study. PLoS Med 9: e1001305.
  78. Pearson RD, 2016. Genomic analysis of local variation and recent evolution in Plasmodium vivax. Nat Genet 48: 959964.
  79. Ménard D, 2010. Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. Proc Natl Acad Sci USA 107: 59675971.
  80. Luo Z, Sullivan SA, Carlton JM, , 2015. The biology of Plasmodium vivax explored through genomics. Ann N Y Acad Sci 1342: 5361.
  81. Ntumngia FB, Thomson-Luque R, Torres L de M, Gunalan K, Carvalho LH, Adams JH, , 2016. A novel erythrocyte binding protein of Plasmodium vivax suggests an alternate invasion pathway into Duffy-positive reticulocytes. MBio 7: e0126116.
  82. Price RN, von Seidlein L, Valecha N, Nosten F, Baird JK, White NJ, , 2014. Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis. Lancet Infect Dis 14: 982991.
  83. Douglas NM, Anstey NM, Angus BJ, Nosten F, Price RN, , 2010. Artemisinin combination therapy for vivax malaria. Lancet Infect Dis 10: 405416.
  84. William T, Menon J, Rajahram G, Chan L, Ma G, Donaldson S, Khoo S, Fredrick C, Jelip J, Anstey NM, , 2011. Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia. Emerg Infect Dis 17: 1248.
  85. Mueller I, Zimmerman PA, Reeder JC, , 2007. Plasmodium malariae and Plasmodium ovale—the “bashful” malaria parasites. Trends Parasitol 23: 278283.
  86. Home Page—ClinicalTrials.gov. Available at: https://clinicaltrials.gov/. Accessed August 25, 2017.
  87. Takeuchi R, 2010. Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border. Malar J 9: 308.
  88. John GK, Douglas NM, von Seidlein L, Nosten F, Baird JK, White NJ, Price RN, , 2012. Primaquine radical cure of Plasmodium vivax: a critical review of the literature. Malar J 11: 280.
  89. Douglas NM, Poespoprodjo JR, Patriani D, Malloy MJ, Kenangalem E, Sugiarto P, Simpson JA, Soenarto Y, Anstey NM, Price RN, , 2017. Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: a hospital-based cohort study. PLoS Med 14: e1002379.
  90. Howes RE, 2013. Spatial distribution of G6PD deficiency variants across malaria-endemic regions. Malar J 12: 418.
  91. Newby G, 2015. Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg 93: 125134.
  92. Tseroni M, 2015. Prevention of malaria resurgence in Greece through the association of mass drug administration (MDA) to immigrants from malaria-endemic regions and standard control measures. PLoS Negl Trop Dis 9: e0004215.
  93. Krotoski WA, , 1980. Frequency of relapse and primaquine resistance in southeast Asian vivax malaria. N Engl J Med 303: 587.
  94. John CC, , 2016. Primaquine plus artemisinin combination therapy for reduction of malaria transmission: promise and risk. BMC Med 14: 65.
  95. Bennett JW, Pybus BS, Yadava A, Tosh D, Sousa JC, McCarthy WF, Deye G, Melendez V, Ockenhouse CF, , 2013. Primaquine failure and cytochrome p-450 2D6 in Plasmodium vivax malaria. N Engl J Med 369: 13811382.
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  • Received : 16 Nov 2017
  • Accepted : 14 Mar 2018

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