1921
Volume 98, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Given limited data on norovirus vaccine acceptance, we performed an exploratory survey in a rural Guatemalan community on knowledge, interest, and willingness to pay (WTP) for a norovirus vaccine. Cluster-randomized households with children aged 6 weeks to 17 years were enrolled into one of two norovirus surveillance studies: 1) a prospective cohort ( = 207 households) and 2) two separate, community-based, cross-sectional surveys ( = 420 households). After completion of the surveillance study, vaccine surveys were completed by 564 (90%) of 627 households. Most households correctly answered questions regarding norovirus symptoms and transmission; 97% indicated interest in a hypothetical norovirus vaccine. Households with higher education had greater WTP for a vaccine (prevalence ratios = 2.2, 95% confidence interval: 1.2–3.1) and households with lower WTP were more likely to use pharmacies, the Ministry of Health, and radios for health care and information. These results suggest that a future norovirus vaccination program could be acceptable and feasible even in rural areas.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.17-0771
2018-03-26
2019-11-13
Loading full text...

Full text loading...

/deliver/fulltext/14761645/98/5/tpmd170771.html?itemId=/content/journals/10.4269/ajtmh.17-0771&mimeType=html&fmt=ahah

References

  1. Ahmed SM, Hall AJ, Robinson AE, Verhoef L, Premkumar P, Parashar UD, Koopmans M, Lopman BA, , 2014. Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis. Lancet Infect Dis 14: 725730. [Google Scholar]
  2. Pires SM, Fischer-Walker CL, Lanata CF, Devleesschauwer B, Hall AJ, Kirk MD, Duarte AS, Black RE, Angulo FJ, , 2015. Aetiology-specific estimates of the global and regional incidence and mortality of diarrhoeal diseases commonly transmitted through food. PLoS One 10: e0142927. [Google Scholar]
  3. Lopman BA, , 2015. Global Burden of Norovirus and Prospects for Vaccine Development. Atlanta, Georgia: Centers for Disease Control and Prevention.
  4. Baehner F, Bogaerts H, Goodwin R, , 2016. Vaccines against norovirus: state of the art trials in children and adults. Clin Microbiol Infect 22 (Suppl 5): S136S139. [Google Scholar]
  5. World Health Organization, 2014. Report of the SAGE Working Group on Vaccine Hesitancy. Geneva, Switzerland: WHO.
  6. Cobos Munoz D, Monzon Llamas L, Bosch-Capblanch X, , 2015. Exposing concerns about vaccination in low- and middle-income countries: a systematic review. Int J Public Health 60: 767780. [Google Scholar]
  7. Dube E, Gagnon D, Nickels E, Jeram S, Schuster M, , 2014. Mapping vaccine hesitancy–country-specific characteristics of a global phenomenon. Vaccine 32: 66496654. [Google Scholar]
  8. Larson HJ, Schulz WS, Tucker JD, Smith DM, , 2015. Measuring vaccine confidence: introducing a global vaccine confidence index. Plos Curr 7, doi: 10.1371/currents.outbreaks.ce0f6177bc97332602a8e3fe7d7f7cc4. [Google Scholar]
  9. D’Ardenne KK, Darrow J, Furniss A, Chavez C, Hernandez H, Berman S, Asturias EJ, , 2016. Use of rapid needs assessment as a tool to identify vaccination delays in Guatemala and Peru. Vaccine 34: 17191725. [Google Scholar]
  10. Merten S, Schaetti C, Manianga C, Lapika B, Hutubessy R, Chaignat CL, Weiss M, , 2013. Sociocultural determinants of anticipated vaccine acceptance for acute watery diarrhea in early childhood in Katanga Province, Democratic Republic of Congo. Am J Trop Med Hyg 89: 419425. [Google Scholar]
  11. Sundaram N, Schaetti C, Merten S, Schindler C, Ali SM, Nyambedha EO, Lapika B, Chaignat CL, Hutubessy R, Weiss MG, , 2016. Sociocultural determinants of anticipated oral cholera vaccine acceptance in three African settings: a meta-analytic approach. BMC Public Health 16: 36. [Google Scholar]
  12. Olson D, Lamb MM, Lopez MR, Paniagua-Avila MA, Zacarias A, Samayoa-Reyes G, Cordon-Rosales C, Asturias EJ, , 2017. A rapid epidemiological tool to measure the burden of norovirus infection and disease in resource-limited settings. Open Forum Infect Dis 4: ofx049. [Google Scholar]
  13. Estevez A, 2013. Prevalence and genetic diversity of norovirus among patients with acute diarrhea in Guatemala. J Med Virol 85: 12931298. [Google Scholar]
  14. Asturias EJ, 2016. The center for human development in Guatemala: an innovative model for global population health. Adv Pediatr 63: 357387. [Google Scholar]
  15. Larson HJ, Jarrett C, Schulz WS, Chaudhuri M, Zhou Y, Dube E, Schuster M, MacDonald NE, Wilson R, , 2015. Measuring vaccine hesitancy: the development of a survey tool. Vaccine 33: 41654175. [Google Scholar]
  16. Godoi IP, Santos AS, Reis EA, Lemos LL, Brandao CM, Alvares J, Acurcio FA, Godman B, Guerra AA, Jr., 2017. Consumer willingness to pay for dengue vaccine (CYD-TDV, Dengvaxia®) in Brazil: implications for future pricing considerations. Front Pharmacol 8: 41. [Google Scholar]
  17. MacDougall DM, Halperin BA, Langley JM, MacKinnon-Cameron D, Li L, Halperin SA, Maritime Universal Rotavirus Vaccination Program (MURVP); , 2016. Knowledge, attitudes, beliefs, and behaviors of parents and healthcare providers before and after implementation of a universal rotavirus vaccination program. Vaccine 34: 687695. [Google Scholar]
  18. Madsen LB, Ustrup M, Fischer TK, Bygbjerg IC, Konradsen F, , 2012. Reduced price on rotavirus vaccines: enough to facilitate access where most needed? Bull World Health Organ 90: 554556. [Google Scholar]
  19. Kabakama S, Gallagher KE, Howard N, Mounier-Jack S, Burchett HE, Griffiths UK, Feletto M, LaMontagne DS, Watson-Jones D, , 2016. Social mobilisation, consent and acceptability: a review of human papillomavirus vaccination procedures in low and middle-income countries. BMC Public Health 16: 834. [Google Scholar]
  20. Morin A, Lemaitre T, Farrands A, Carrier N, Gagneur A, , 2012. Maternal knowledge, attitudes and beliefs regarding gastroenteritis and rotavirus vaccine before implementing vaccination program: which key messages in light of a new immunization program? Vaccine 30: 59215927. [Google Scholar]
  21. Schollin Ask L, Hjern A, Lindstrand A, Olen O, Sjogren E, Blennow M, Ortqvist A, , 2017. Receiving early information and trusting Swedish child health centre nurses increased parents’ willingness to vaccinate against rotavirus infections. Acta Paediatr 106: 13091316. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.17-0771
Loading
/content/journals/10.4269/ajtmh.17-0771
Loading

Data & Media loading...

  • Received : 03 Oct 2017
  • Accepted : 28 Jan 2018
  • Published online : 26 Mar 2018

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error