Volume 98, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



In the Bolivian Chaco, south-east of Bolivia, studies conducted over the past three decades reported hepatitis A virus (HAV) and seroprevalences above 90% and 60%, respectively. Hepatitis E virus (HEV) prevalence was previously found to be 6–7% but is probably an underestimate because of the poor sensitivity of the assays used. In November 2013, we conducted a cross-sectional study of 263 healthy volunteers from two rural communities of the Bolivian Chaco, aiming to reassess HAV, HEV, and seroprevalence 10–20 years following the previous surveys. Hepatitis A virus seroprevalence was 95%, with universal exposure after the first decade of life; HEV seroprevalence was considerably higher (31–35%) than that previously reported; seroprevalence was 59%, with an age-dependent distribution. The high prevalence of these infections suggests that major efforts are still needed to reduce fecal–oral transmission and to improve human health in the Bolivian Chaco.


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  • Received : 26 Sep 2017
  • Accepted : 31 Dec 2017
  • Published online : 26 Mar 2018

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