Volume 98, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Severe congenital malaria associated with is uncommon. In Indonesia, most congenital malaria cases are due to infections. Most cases of congenital or neonatal malaria in endemic areas are diagnosed from peripheral smear as part of routine sepsis workup. Differentiating congenital and acquired neonatal malaria is very difficult. The case presented in this study describes severe malaria with cholestatic jaundice and sepsis-like signs and symptoms in neonates. The mother was asymptomatic and the neonate was successfully treated with intravenous artesunate. Severe malaria with cholestatic jaundice in neonates is an uncommon condition that should be included in the differential diagnosis of infants displaying hemolytic anemia, thrombocytopenia, cholestatic jaundice, and hepatosplenomegaly in malaria-endemic zones. Early diagnosis can prevent the use of unnecessary antibiotics and mortality of neonates.


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  1. Raza F, Shariq Y, Iqbal Z, Aghai S, Aziz S, , 2017. Congenital malaria in a neonate: a rare condition. ASH KMDC 22: 7174. [Google Scholar]
  2. World Health Organization, 2014. Severe malaria. Trop Med Int Health 19 (Suppl 1): 7131. [Google Scholar]
  3. Pineros-Jimenez JG, Alvarez G, Tobon A, Arboleda M, Carrero S, Blair S, , 2011. Congenital malaria in Uraba, Colombia. Malar J 10: 18. [Google Scholar]
  4. Bhatia R, Rajwaniya D, Agrawal P, , 2016. Case Report: Congenital Malaria due to Plasmodium vivax Infection in a Neonate. Udaipur, India: Department of Pediatrics, Pacific Medical College and Hospital, Hindawi Publishing Corporation, 12.
  5. Bagri DR, Mathur P, , 2016. P. vivax malaria: a rare cause of cholestatic jaundice in a neonate. Sch J Med Case Rep 4: 315317. [Google Scholar]
  6. Thapar RK, Saxena A, Devgan A, , 2008. Congenital malaria. Med J Armed Forces India 64: 185186. [Google Scholar]
  7. Clemens SCM, Rutgers MM, de Winter JP, Sloot SC, Jager MM, Mank TG, , 2017. Congenital Plasmodium vivax malaria in a non-endemic country; a unique case in the Netherlands. Pediatric Infect Dis 2: 3335. [Google Scholar]
  8. Jain A, Kaushik R, Kaushik RM, , 2016. Malarial hepatopathy: clinical profile and association with other malarial complications. Acta Trop 159: 95105. [Google Scholar]
  9. Punta VD, Gulleta M, Matteelli A, Spinoni V, Regazzoli A, Castelli F, , 2010. Congenital Plasmodium vivax malaria mimicking neonatal sepsis: a case report. Malar J 9: 13. [Google Scholar]
  10. Elyazar IR, Gething PW, Patil AP, Rogayah H, Kusriastuti R, Wismarini DM, Tarmizi SN, Baird JK, Hay SI, , 2011. Plasmodium falciparum malaria endemicity in Indonesia in 2010. PLoS One 6: e21315. [Google Scholar]
  11. Varma S, Bhatt AS, , 2016. Unusual clinical presentation of congenital malaria: cholestasis in newborn. Adv Res Gastroentero Hepatol 1: 13. [Google Scholar]
  12. Naniche D, 2012. Reduction of antimalarial antibodies by HIV infection is associated with increased risk of Plasmodium falciparum cord blood infection. J Infect Dis 205: 568577. [Google Scholar]
  13. Moya-Alvarez V, Abellana R, Cot M, , 2014. Pregnancy-associated malaria in infants: an old problem with present consequences. Malar J 13: 271. [Google Scholar]
  14. Uneke CJ, , 2011. Congenital malaria: an overview. Tanzan J Health Res 13: 118. [Google Scholar]
  15. Lesko CR, Arguin PM, Newman RD, , 2007. Congenital malaria in the United States: a review of cases from 1966 to 2005. Arch Pediatr Adolesc Med 161: 10621067. [Google Scholar]
  16. Poespoprodjo JR, Hasanuddin A, Fobia W, Sugiarto P, Kenangalem E, Lampah DA, Tjitra E, Price RN, Anstey NM, , 2010. Case report: severe congenital malaria acquired in utero. Am J Trop Med Hyg 82: 563565. [Google Scholar]
  17. Liu X, Tao ZY, Fang Q, Wang XM, Zhang H, Stoute JA, Xia H, Cui L, , 2012. A case of congenital Plasmodium vivax malaria from a temperate region in Central China. Malar J 11: 182185. [Google Scholar]
  18. Douglas NM, Anstey NM, Buffet PA, Poespoprodjo JR, Yeo TW, White NJ, Price RN, , 2012. The anaemia of Plasmodium vivax malaria. Malar J 11: 135149. [Google Scholar]
  19. Poespoprodjo JR, Fobia W, Kenangalem E, Lampah DA, Hasanuddin A, Warikar N, Sugiarto P, Tjitra E, Anstey NM, Price RN, , 2009. Vivax malaria: a major cause of morbidity in early infancy. Clin Infect Dis 48: 17041712. [Google Scholar]
  20. Autino B, Corbett Y, Castelli F, Taramelli D, , 2012. Pathogenesis of malaria in tissues and blood. Mediterr J Hematol Infect Dis 4: e2012061. [Google Scholar]
  21. Bhalla A, Suri V, Singh V, , 2006. Malarial hepatopathy. J Postgrad Med 52: 315320. [Google Scholar]
  22. Kochar DK, Singh P, Agarwal P, Kochar SK, Pokharna R, Sareen PK, , 2003. Malarial hepatitis. J Assoc Physicians India 51: 10691072. [Google Scholar]
  23. Gathwala G, Dalal P, Gupta M, , 2015. Congenital malaria with atypical presentation: a series of three case reports. J Clin Neonatol 4: 206208. [Google Scholar]
  24. Feldman AG, Sokol RJ, , 2013. Neonatal cholestasis. Neoreviews 14: pii: e63. [Google Scholar]
  25. World Health Organization, 2015. Guidelines for the Treatment of Malaria, 3rd edition. Geneva, Switzerland: World Health Organization Global Malaria Programme.
  26. Maestre A, Carmona-Fonseca J, , 2014. Immune responses during gestational malaria: a review of the current knowledge and future trend of research. J Infect Dev Ctries 8: 391402. [Google Scholar]

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  • Received : 21 Sep 2017
  • Accepted : 19 Nov 2017
  • Published online : 08 Jan 2018

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