1921
Volume 98, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Zika virus (ZIKV), an emerging mosquito-borne flavivirus, causes a dengue-like infection that has recently caught global attention. The infection, which also includes some birth defects, has been documented in the Americas, Pacific Islands, and some parts of Africa and Asia. There are no published reports on local ZIKV transmission in Myanmar. In this study, a total of 462 serum samples from patients and asymptomatic persons were collected in Myanmar from 2004 to 2017. They were analyzed for ZIKV infection by immunoglobulin M capture enzyme-linked immunosorbent assay (ELISA), immunoglobulin G indirect ELISA, neutralization test, real-time polymerase chain reaction (PCR), and conventional PCR. Our study confirmed ZIKV infection in 4.9% of patients with clinical dengue symptoms and in 8.6% of persons who were asymptomatic. This is the first report on ZIKV infection in Myanmar and it suggests the occurrence of ZIKV infection in two geographically distinct sites in this country since at least 2006.

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References

  1. Mlakar J, 2016. Zika virus associated with microcephaly. N Engl J Med 374: 951958. [Google Scholar]
  2. Petersen EE, Staples JE, Meaney-Delman D, Fischer M, Ellington SR, Callaghan WM, Jamieson DJ, , 2016. Interim guidelines for pregnant women during a Zika virus outbreak—United States, 2016. MMWR Morb Mortal Wkly Rep 65: 3033. [Google Scholar]
  3. Thu HM, Lowry K, Myint TT, Shwe TN, Han AM, Khin KK, Thant KZ, Thein S, Aaskov J, , 2004. Myanmar dengue outbreak associated with displacement of serotypes 2, 3, and 4 by dengue 1. Emerg Infect Dis 10: 593597. [Google Scholar]
  4. WHO, 2008. Myanmar Joint Plan of Action Scaling Up Dengue Prevention and Control. Available at: http://www.who.int/hac/crises/mmr/myanmar_joint_plan_of_action_dengue_2008.pdf. Accessed September 1, 2008.
  5. WHO, 2016. First Case of Zika Virus Infection Detected in Myanmar; Mosquito Control Measures Must Be at the Forefront of the Fight Against Vector-Borne Diseases. Available at: http://www.searo.who.int/myanmar/areas/zika_firstcaseinmyanmar/en/. Accessed October 28, 2016.
  6. Ngwe Tun MM, 2013. Serological characterization of dengue virus infections observed among dengue hemorrhagic fever/dengue shock syndrome cases in upper Myanmar. J Med Virol 85: 12581266. [Google Scholar]
  7. Inoue S, 2010. Evaluation of a dengue IgG indirect enzyme-linked immunosorbent assay and a Japanese encephalitis IgG indirect enzyme-linked immunosorbent assay for diagnosis of secondary dengue virus infection. Vector Borne Zoonotic Dis 10: 143150. [Google Scholar]
  8. Moi ML, 2017. Zika virus infection and microcephaly in Vietnam. Lancet Infect Dis 17: 805806. [Google Scholar]
  9. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, Stanfield SM, Duffy MR, , 2008. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 14: 12321239. [Google Scholar]
  10. Wilson HL, Tran T, Druce J, Dupont-Rouzeyrol M, Catton M, , 2017. Neutralization assay for Zika and dengue viruses by use of real-time-PCR-based endpoint assessment. J Clin Microbiol 55: 31043112. [Google Scholar]
  11. Grard G, Caron M, Mombo IM, Nkoghe D, Mboui Ondo S, Jiolle D, Fontenille D, Paupy C, Leroy EM, , 2014. Zika virus in Gabon (Central Africa)—2007: a new threat from Aedes albopictus? PLoS Negl Trop Dis 8: e2681. [Google Scholar]
  12. WHO, 2016. Zika Definition. Available at: http://www.who.int/csr/disease/zika/case-definition/en/. Accessed February 12, 2016.
  13. Duffy MR, 2009. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 360: 25362543. [Google Scholar]
  14. Monath TP, Nystrom RR, Bailey RE, Calisher CH, Muth DJ, , 1984. Immunoglobulin M antibody capture enzyme-linked immunosorbent assay for diagnosis of St. Louis encephalitis. J Clin Microbiol 20: 784790. [Google Scholar]
  15. Ruckert C, Weger-Lucarelli J, Garcia-Luna SM, Young MC, Byas AD, Murrieta RA, Fauver JR, Ebel GD, , 2017. Impact of simultaneous exposure to arboviruses on infection and transmission by Aedes aegypti mosquitoes. Nat Commun 8: 15412. [Google Scholar]
  16. Dupont-Rouzeyrol M, O’Connor O, Calvez E, Daures M, John M, Grangeon JP, Gourinat AC, , 2015. Co-infection with Zika and dengue viruses in 2 patients, New Caledonia, 2014. Emerg Infect Dis 21: 381382. [Google Scholar]
  17. Ngwe Tun MM, 2017. Dengue associated acute encephalitis syndrome cases in Son La Province, Vietnam in 2014. Jpn J Infect Dis 70: 357361. [Google Scholar]
  18. de Araujo TVB, 2016. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study. Lancet Infect Dis 16: 13561363. [Google Scholar]
  19. Martelli CMT, Castanha P, Cortes F, Rodrigues L, Marques ET, Eder M, , 2016. High levels of exposure of Zika and dengue infections detected using plaque reduction neutralization assay in Brazil. Int J Infect Dis 53: 15. [Google Scholar]
  20. Aubry M, 2017. Zika virus seroprevalence, French Polynesia, 2014–2015. Emerg Infect Dis 23: 669672. [Google Scholar]
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  • Received : 10 Sep 2017
  • Accepted : 08 Dec 2017
  • Published online : 22 Jan 2018

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