1921
image of Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to Leishmania braziliensis
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

To evaluate the dynamics of regulatory T cells (Tregs) during tegumentary leishmaniasis, we assessed peripheral blood and biopsies from 54 patients. Patients with cutaneous leishmaniasis (CL) had a decreased proportion of Tregs in the peripheral blood, but the proportion was higher in the biopsies of lesions. During treatment of CL, circulating Tregs increased reaching normal proportions, whereas antigen-specific interferon-γ responses diminished. By contrast, circulating Tregs from mucosal leishmaniasis patients failed to normalize during treatment. CCR5 was expressed on a large proportion of Tregs at the site of infection. These results demonstrate increased Tregs at the site of infection, possibly homing from the peripheral circulation.

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/content/journals/10.4269/ajtmh.17-0624
2018-02-05
2018-02-20
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.17-0624
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  • Published online : 05 Feb 2018
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