Volume 98, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Repeated oral azithromycin distribution targeted only to children has proven effective in reducing the ocular that causes trachoma. Here, we assess whether an enhanced coverage target of at least 90% of children is superior to the World Health Organization recommendation of at least 80%. Twenty-four trachoma-endemic communities in Matamèye, Niger, were randomized to a single day of azithromycin distribution aiming for at least 80% coverage or up to 4 days of treatment and > 90% coverage of children under age 12. All distributions were biannual. Children < 5 years of age and adults > 15 years were monitored for ocular infection by polymerase chain reaction every 6 months for 36 months in children and at baseline and 36 months in adults. Ocular prevalence in children decreased from 24.9% (95% confidence interval [CI] 15.9–33.8%) to 4.4% (95% CI 0.6–8.2%, < 0.001) at 36 months in the standard coverage arm and from 15.6% (95% CI 10.0–21.2%) to 3.3% (95% CI 1.0–5.5%; < 0.001) in the enhanced coverage arm. Enhanced coverage reduced ocular prevalence in children more quickly over time compared with standard ( = 0.04). There was no difference between arms at 36 months in children (2.4% lower with enhanced coverage, 95% CI 7.7–12.5%; = 0.60). No infection was detected in adults at 36 months. Increasing antibiotic coverage among children from 80% to 90% may yield only short term improvements for trachoma control programs. Targeting treatment to children alone may be sufficient for trachoma control in this setting.


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  • Received : 23 Jun 2017
  • Accepted : 23 Aug 2017
  • Published online : 18 Dec 2017

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