1921
Volume 98, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We conducted a population-based study of tuberculosis (TB) from 2009 to 2015 in an indigenous community of Brazil, the largest in the country, to investigate risk factors associated with recent TB transmission. The clinical isolates of were genotyped by IS-RFLP (restriction fragment length polymorphism) and spoligotyping analysis. Among 67 isolates typed by RFLP, 69% fell into fifteen clusters, and 91% of TB cases with shared IS-RFLP pattern were diagnosed within 2 years of another case in the cluster. Individual risk factors associated with genetic clustering were domestic overcrowding (odds ratio [OR]: 6.10; 95% confidence interval [CI]: 1.50–24.88) and low social class (OR: 3.72; 95% CI: 1.00–13.98). Most reported contacts (76%) were identified within the household of the index TB case, but most of the genetic clustering of occurred outside of household (79%). Expanded contacts investigation and prophylaxis outside of household should be considered as a priority for TB control programs in this population.

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References

  1. Castro DB, Pinto RC, Albuquerque BC, Sadahiro M, Braga JU, , 2016. The socioeconomic factors and the indigenous component of tuberculosis in Amazonas. PLoS One 11: e0158574. [Google Scholar]
  2. Basta PC, Coimbra CE, Jr Welch JR, Correa Alves LC, Santos RV, Bastos Camacho LA, , 2010. Tuberculosis among the Xavante Indians of the Brazilian Amazon: an epidemiological and ethnographic assessment. Ann Hum Biol 37: 643657. [Google Scholar]
  3. Malacarne J, Rios DP, Silva CM, Braga JU, Camacho LA, Basta PC, , 2016. Prevalence and factors associated with latent tuberculosis infection in an indigenous population in the Brazilian Amazon. Rev Soc Bras Med Trop 49: 456464. [Google Scholar]
  4. Cunha EA, Ferrazoli L, Riley LW, Basta PC, Honer MR, Maia R, Costa IP, , 2014. Incidence and transmission patterns of tuberculosis among indigenous populations in Brazil. Mem Inst Oswaldo Cruz 109: 108113. [Google Scholar]
  5. ABEP, 2015. Brazilian Economic Classification Criterion [in Portuguese]. Available at: www.abep.org. Accessed June 15, 2017.
  6. Fiske CT, Yan FX, Hirsch-Moverman Y, Sterling TR, Reichler MR, , Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team, 2014. Risk factors for treatment default in close contacts with latent tuberculous infection. Int J Tuberc Lung Dis 18: 421427. [Google Scholar]
  7. van Embden JD, 1993. Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology. J Clin Microbiol 31: 406409. [Google Scholar]
  8. Demay C, Liens B, Burguière T, Hill V, Couvin D, Millet J, Mokrousov I, Sola C, Zozio T, Rastogi N, , 2012. SITVITWEB–a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology. Infect Genet Evol 12: 755766. [Google Scholar]
  9. United Nations Permanent Forum on Indigenous Issues, 2012. State of the World’s Indigenous Peoples. ST/ESA/328. New York, NY: United Nations. Available at: http://www.unhcr.org/refworld/docid/4b6700ed2.html. Accessed December 10, 2012.
  10. Tollefson D, Bloss E, Fanning A, Redd JT, Barker K, McCray E, , 2013. Burden of tuberculosis in indigenous peoples globally: a systematic review. Int J Tuberc Lung Dis 17: 11391150. [Google Scholar]
  11. National Collaborating Centre for Aboriginal Health, 2010. Housing as a Social Determinant of First Nations, Inuit and Métis Health. Available at: http://www.nccah-ccnsa.ca/docs/fact%20sheets/social%20determinates/NCCAH_fs_housing_EN.pdf. Accessed October 5, 2014.
  12. Middelkoop K, Mathema B, Myer L, Shashkina E, Whitelaw A, Kaplan G, Kreiswirth B, Wood R, Bekker LG, , 2015. Transmission of tuberculosis in a South African community with a high prevalence of HIV infection. J Infect Dis 211: 5361. [Google Scholar]
  13. Glynn JR, Whiteley J, Bifani PJ, Kremer K, van Soolingen D, , 2002. Worldwide occurrence of Beijing/W strains of Mycobacterium tuberculosis: a systematic review. Emerg Infect Dis 8: 843849. [Google Scholar]
  14. Puma DV, Perez-Quilez O, Roure S, Martinez-Cuevas O, Bocanegra C, Feijoo-Cid M, Valerio L, , 2017. Risk of active tuberculosis among index case of householders—A long-term assessment after the conventional contacts study. Public Health Nurs 34: 112117. [Google Scholar]
  15. Fox GJ, Barry SE, Britton WJ, Marks GB, , 2013. Contact investigation for tuberculosis: a systematic review and meta-analysis. Eur Respir J 41: 140156. [Google Scholar]
  16. Yuhara LS, Sacchi FP, Croda J, , 2013. Impact of latent infection treatment in indigenous populations. PLoS One 8: e71201. [Google Scholar]
  17. Saavedra-Campos M, Welfare W, Cleary P, Sails A, Burkitt A, Hungerford D, Okereke E, Acheson P, Petrovic M, , 2016. Identifying areas and risk groups with localised Mycobacterium tuberculosis transmission in northern England from 2010 to 2012: spatiotemporal analysis incorporating highly discriminatory genotyping data. Thorax 71: 742748. [Google Scholar]
  18. Fenner L, 2012. Mycobacterium tuberculosis transmission in a country with low tuberculosis incidence: role of immigration and HIV infection. J Clin Microbiol 50: 388395. [Google Scholar]
  19. Samuel B, 2016. Relationship between nutritional support and tuberculosis treatment outcomes in West Bengal, India. J Tuberc Res 4: 213219. [Google Scholar]
  20. Gomes HM, 2012. Spoligotypes of Mycobacterium tuberculosis complex isolates from patients residents of 11 states of Brazil. Infect Genet Evol 12: 649656. [Google Scholar]
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  • Received : 17 Jun 2017
  • Accepted : 23 Oct 2017
  • Published online : 04 Dec 2017

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