Volume 98, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Insecticide resistance (IR) monitoring is an important component of vector-borne disease control. The last assessment of IR in Papua New Guinea (PNG) was conducted in 2010. Since then, vector populations have been exposed to higher levels of pyrethroids with the continued nation-wide distribution of insecticide-treated nets. Here, we provide an update on phenotypic IR in four highly malaria-endemic areas of PNG. IR against deltamethrin, lambda-cyhalothrin, and dichlorodiphenyltrichloroethane was assessed using World Health Organization bioassays. A total of 108 bioassays for each insecticide were conducted screening 2,290 adult female anopheline mosquitoes. No phenotypic resistance was observed. Bioassay parameters agreed well with those observed in other studies that used the same assays and insecticides. These results indicate that the three tested insecticides are still universally effective in PNG. Continued IR monitoring (every 1–2 years) in PNG is recommended to detect reduced susceptibility early and adjust guidelines to prevent widespread resistance.


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  1. Hetzel MW, Choudhury AA, Pulford J, Ura Y, Whittaker M, Siba PM, Mueller I, , 2014. Progress in mosquito net coverage in Papua New Guinea. Malar J 13: 242. [Google Scholar]
  2. Hetzel MW, 2017. Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014. Bull World Health Organ 95: 695705B. [Google Scholar]
  3. Hetzel MW, Reimer LJ, Gideon G, Koimbu G, Barnadas C, Makita L, Siba PM, Mueller I, , 2016. Changes in malaria burden and transmission in sentinel sites after the roll-out of long-lasting insecticidal nets in Papua New Guinea. Parasit Vectors 9: 340. [Google Scholar]
  4. Ranson H, Lissenden N, , 2016. Insecticide resistance in African Anopheles mosquitoes: a worsening situation that needs urgent action to maintain malaria control. Trends Parasitol 32: 187196. [Google Scholar]
  5. Chaumeau V, Cerqueira D, Zadrozny J, Kittiphanakun P, Andolina C, Chareonviriyaphap T, Nosten F, Corbel V, , 2017. Insecticide resistance in malaria vectors along the Thailand-Myanmar border. Parasit Vectors 10: 165. [Google Scholar]
  6. Hemingway J, Hawkes NJ, McCarroll L, Ranson H, , 2004. The molecular basis of insecticide resistance in mosquitoes. Insect Biochem Mol Biol 34: 653665. [Google Scholar]
  7. Keven JB, Henry-Halldin CN, Thomsen EK, Mueller I, Siba PM, Zimmerman PA, Reimer LJ, , 2010. Pyrethroid susceptibility in natural populations of the Anopheles punctulatus group (Diptera: Culicidae) in Papua New Guinea. Am J Trop Med Hyg 83: 12591261. [Google Scholar]
  8. Reimer LJ, Thomsen EK, Koimbu G, Keven JB, Mueller I, Siba PM, Kazura JW, Hetzel MW, Zimmerman PA, , 2016. Malaria transmission dynamics surrounding the first nationwide long-lasting insecticidal net distribution in Papua New Guinea. Malar J 15: 25. [Google Scholar]
  9. Thomsen EK, Koimbu G, Pulford J, Jamea-Maiasa S, Ura Y, Keven JB, Siba PM, Mueller I, Hetzel MW, Reimer LJ, , 2016. Mosquito behaviour change after distribution of bednets results in decreased protection against malaria exposure. J Infect Dis 215: 790797. [Google Scholar]
  10. Parkinson AD, , 1974. Malaria in Papua New Guinea 1973. P N G Med J 17: 816. [Google Scholar]
  11. Nardini L, Christian RN, Coetzer N, Koekemoer LL, , 2013. DDT and pyrethroid resistance in Anopheles arabiensis from South Africa. Parasit Vectors 6: 229. [Google Scholar]
  12. WHO, 2013. Test Procedures for Insecticide Resistance Monitoring in Malaria Vector Mosquitoes. Geneva, Switzerland: World Health Organization.
  13. Lukwa N, Sande S, Munosiyei P, Zimba M, , 2012. Insecticide susceptibility tests conducted in Kamhororo, Masakadza and Chilonga villages in Zimbabwe during the 2011 malaria period. J Entomol Acarol Res 44: e19. [Google Scholar]
  14. Hetzel MW, 2014. Evaluation of the Global Fund-supported National Malaria Control Program in Papua New Guinea, 2009-2014. P N G Med J 57: 729. [Google Scholar]

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Supplemental Table

  • Received : 11 Jun 2017
  • Accepted : 20 Sep 2017
  • Published online : 06 Nov 2017

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