1921
Volume 98, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Acute Q fever cases were identified from a hospital-based acute febrile illness study conducted in six community hospitals in rural north and northeast Thailand from 2002 to 2005. Of 1,784 participants that underwent testing, nine (0.5%) participants were identified in this case-series as acute Q fever cases. Eight case-patients were located in one province. Four case-patients were hospitalized. Median age was 13 years (range: 7–69); five were male. The proportion of children with acute Q fever infection was similar to adults ( = 0.17). This previously unrecognized at-risk group, school-age children, indicates that future studies and prevention interventions should target this population. The heterogeneity of disease burden across Thailand and milder clinical presentations found in this case-series should be considered in future studies. As diagnosis based on serology is limited during the acute phase of the disease, other diagnostic options, such as polymerase chain reaction, should be explored to improve acute case detection.

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References

  1. Parker NR, Barralet JH, Bell AM, , 2006. Q fever. Lancet 367: 679688. [Google Scholar]
  2. Gürtler L, 2014. Coxiella burnetii—pathogenic agent of Q (Query) fever. Transfus Med Hemother 41: 6072. [Google Scholar]
  3. Centers for Disease Control and Prevention, 2013. Diagnosis and management of Q fever–United States, 2013. MMWR 3: 129. [Google Scholar]
  4. Plummer PJ, , 2015. Overview of Coxiellosis. The Merck Veterinary Manual. Kenilworth, NJ: Merck & Co., Inc.
  5. Maurin M, Raoult D, , 1999. Q Fever. Clin Microbiol Rev 12: 518553. [Google Scholar]
  6. Delsing CE, Kullberg BJ, Bleeker-Rovers CP, , 2010. Q fever in the Netherlands from 2007 to 2010. Neth J Med 68: 382387. [Google Scholar]
  7. Raoult D, , 2012. Chronic Q fever: expert opinion versus literature analysis and consensus. J Infect 65: 102108. [Google Scholar]
  8. Eldin C, Raoult D, , 2016. Moving from Q fever to C. burnetii infection. Epidemiol Infect 144: 11631164. [Google Scholar]
  9. Rolain JM, Mallet MN, Raoult D, , 2003. Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis. J Infect Dis 188: 13221325. [Google Scholar]
  10. Eldin C, Mailhe M, Lions C, Carrieri P, Safi H, Brouqui P, Raoult D, , 2016. Treatment and prophylactic strategy for Coxiella burnetii infection of aneurysms and vascular grafts: a retrospective cohort study. Medicine (Baltimore) 95: e2810. [Google Scholar]
  11. Million M, Walter G, Thuny F, Habib G, Raoult D, , 2013. Evolution from acute Q fever to endocarditis is associated with underlying valvulopathy and age and can be prevented by prolonged antibiotic treatment. Clin Infect Dis 57: 836844. [Google Scholar]
  12. Sankasuwan V, Pongpradit P, Bodhidatta P, , 1967. SEATO medical research study on Rickettsial diseases in Thailand. Annual research progress report, US Army-SEATO Medical Research Unit. Bangkok, Thailand: U.S. Army; 1967, 499–504.
  13. Suputtamongkol Y, Rolain J-M, Losuwanaruk K, Niwatayakul K, Suthinont C, Chierakul W, Pimda K, Raoult D, , 2003. Q fever in Thailand. Emerg Infect Dis 9: 11861188. [Google Scholar]
  14. Pachirat O, Fournier PE, Pussadhamma B, Taksinachanekij S, Lulitanond V, Baggett HC, Thamthitiwat S, Watt G, Raoult D, Maloney SA, , 2012. The first reported cases of Q fever endocarditis in Thailand. Infect Dis Rep 4: e7. [Google Scholar]
  15. Dupont HT, Thirion X, Raoult D, , 1994. Q fever serology: cutoff determination for microimmunofluorescence. Clin Diagn Lab Immunol 1: 189196. [Google Scholar]
  16. Mediterranee Infection, 2016. Q Fever: Diagnostic Criteria and Treatment Protocols. Available at: http://en.mediterranee-infection.com/article.php?laref=157&titre=q-fever-treatment. Accessed: November 6, 2016.
  17. Frankel D, Richet H, Renvoisé A, Raoult D, , 2011. Q fever in France, 1985–2009. Emerg Infect Dis 17: 350356. [Google Scholar]
  18. Maltezou HC, Raoult D, , 2002. Q fever in children. Lancet Infect Dis 2: 686691. [Google Scholar]
  19. Hackert VH, Dukers-Muijrers NH, van Loo IH, Wegdam-Blans M, Somers C, Hoebe CJ, , 2015. Coxiella burnetii infection is lower in children than in adults after community exposure: overlooked cause of infrequent Q fever reporting in the young. Pediatr Infect Dis J 34: 12831288. [Google Scholar]
  20. Kobbe R, Kramme S, Kreuels B, Adjei S, Kreuzberg C, Panning M, Adjei O, Fleischer B, May J, , 2008. Q fever in young children, Ghana. Emerg Infect Dis 14: 344346. [Google Scholar]
  21. van der Hoek W, 2013. Short communication: prevalence of antibodies against Coxiella burnetii (Q fever) in children in The Gambia, West Africa. Trop Med Int Health 18: 850853. [Google Scholar]
  22. Fournier PE, Marrie TJ, Raoult D, , 1998. Diagnosis of Q fever. J Clin Microbiol 36: 18231834. [Google Scholar]
  23. Blacksell SD, 2015. Underrecognized arthropod-borne and zoonotic pathogens in northern and northwestern Thailand: serological evidence and opportunities for awareness. Vector Borne Zoonotic Dis 15: 285290. [Google Scholar]
  24. Suttinont C, 2006. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Ann Trop Med Parasitol 100: 363370. [Google Scholar]
  25. Puranavaej S, Winter P, Sankasuwan V, Pongpradit P, Bodhidatta P, , 1968. SEATO medical research study on Rickettsial disease in Thailand. Annual research progress report, US Army-SEATO Medical Research Unit. Bangkok, Thailand: U.S. Army; 1968, 444–448.
  26. Watt G, 2014. Infective endocarditis in northeastern Thailand. Emerg Infect Dis 20: 473476. [Google Scholar]
  27. Yingst SL, Opaschaitat P, Kanitpun R, Thammasart S, Ekgatat M, Jirathanawat V, Wongwicharn P, , 2013. Q fever surveillance in ruminants, Thailand, 2012. Emerg Infect Dis 19: 20562058. [Google Scholar]
  28. Edouard S, Raoult D, , 2016. Lyophilization to improve the sensitivity of qPCR for bacterial DNA detection in serum: the Q fever paradigm. J Med Microbiol 65: 462467. [Google Scholar]
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  • Received : 26 May 2017
  • Accepted : 29 Sep 2017

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