1921
image of Enteropathogens and Gut Inflammation in Asymptomatic Infants and Children in Different Environments in Southern India
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Children in poor environmental conditions are exposed early and often to enteric pathogens, but within developing countries, heterogeneity in enteropathogen exposure in different settings and communities is rarely addressed. We tested fecal samples from healthy infants and children from two different environments in the same Indian town for gut enteropathogens and biomarkers of gut inflammation. A significantly higher proportion of infants and children from a poor semi-urban neighborhood (93%) had one or more enteropathogens than those from a medical college campus (71.7%). Infants and children from the poor neighborhood had an average of 3.3 (95% confidence interval [CI]: 2.9–3.7) enteropathogens compared with an average of 1.4 (95% CI: 1.0–1.7) enteropathogens in campus infants/children. Viral and bacterial infections, including enteroviruses, adenoviruses, spp., and diarrhegenic were more common and fecal biomarkers of inflammation were higher in the poor neighborhood. The findings demonstrate significant difference in the asymptomatic carriage of gut enteropathogens and gut inflammatory biomarkers in infants and children from two different environments within the same town in south India.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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/content/journals/10.4269/ajtmh.17-0324
2017-12-11
2018-01-16
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.17-0324
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  • Published online : 11 Dec 2017
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