1921
Volume 98, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Blood samples from 805 students attending 42 elementary schools in Mopti, Sikasso, and Koulikoro regions, and Bamako district in Mali participated in a school water, sanitation, and hygiene intervention. Immunoglobulin (Ig) G responses to several antigens/pathogens were assessed by a multiplex bead assay (MBA), and the recombinant T24H antigen was included. Of all students tested, 8.0% were positive to rT24H, but in some schools 25–30%. A cluster of 12 widespread school locations showed not only a relative risk of 3.23 for exposure and significantly higher IgG responses ( < 0.001) but also significantly lower elevation ( = 0.04) (m, above sea level) compared with schools outside the cluster. All schools at elevations < 425 m showed significantly higher IgG responses ( = 0.017) than schools at elevations ≥ 425 m. The MBA is an excellent serological platform that provides cost-effective opportunities to expand testing in serosurveys.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.17-0310
2018-03-26
2019-05-24
Loading full text...

Full text loading...

/deliver/fulltext/14761645/98/5/tpmd170310.html?itemId=/content/journals/10.4269/ajtmh.17-0310&mimeType=html&fmt=ahah

References

  1. Garcia HH, Nash TE, Del Brutto OH, , 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 12021215. [Google Scholar]
  2. Nash TE, Garcia HH, , 2011. Diagnosis and treatment of neurocysticercosis. Nat Rev Neurol 7: 584594. [Google Scholar]
  3. Bruno E, Bartoloni A, Zammarchi L, Strohmeyer M, Bartalesi F, Bustos JA, Santivanez S, Garcia HH, Nicoletti A, Group CPS, , 2013. Epilepsy and neurocysticercosis in Latin America: a systematic review and meta-analysis. PLoS Negl Trop Dis 7: e2480. [Google Scholar]
  4. Carabin H, Ndimubanzi PC, Budke CM, Nguyen H, Qian Y, Cowan LD, Stoner JA, Rainwater E, Dickey M, , 2011. Clinical manifestations associated with neurocysticercosis: a systematic review. PLoS Negl Trop Dis 5: e1152. [Google Scholar]
  5. Winkler AS, , 2012. Neurocysticercosis in sub-Saharan Africa: a review of prevalence, clinical characteristics, diagnosis, and management. Pathog Glob Health 106: 261274. [Google Scholar]
  6. Coral-Almeida M, Gabriel S, Abatih EN, Praet N, Benitez W, Dorny P, , 2015. Taenia solium human cysticercosis: a systematic review of sero-epidemiological data from endemic zones around the world. PLoS Negl Trop Dis 9: e0003919. [Google Scholar]
  7. Mwape KE, Phiri IK, Praet N, Speybroeck N, Muma JB, Dorny P, Gabriel S, , 2013. The incidence of human cysticercosis in a rural community of eastern Zambia. PLoS Negl Trop Dis 7: e2142. [Google Scholar]
  8. Braae UC, Saarnak CF, Mukaratirwa S, Devleesschauwer B, Magnussen P, Johansen MV, , 2015. Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa. Parasit Vectors 8: 323. [Google Scholar]
  9. United States Department of State, 2010. Zambia International Religious Freedom Report 2010. Available at: https://www.state.gov/j/drl/rls/irf/2010/148728.htm. Accessed September 3, 2017. [Google Scholar]
  10. Carabin H, Millogo A, Praet N, Hounton S, Tarnagda Z, Ganaba R, Dorny P, Nitiema P, Cowan LD, Evaluation du Fardeau Economique de la Cysticercose Au Burkina F; , 2009. Seroprevalence to the antigens of Taenia solium cysticercosis among residents of three villages in Burkina Faso: a cross-sectional study. PLoS Negl Trop Dis 3: e555. [Google Scholar]
  11. Trinies V, Garn JV, Chang HH, Freeman MC, , 2016. The impact of a school-based water, sanitation, and hygiene program on absenteeism, diarrhea, and respiratory infection: a matched-control trial in Mali. Am J Trop Med Hyg 94: 14181425. [Google Scholar]
  12. Noh J, Rodriguez S, Lee YM, Handali S, Gonzalez AE, Gilman RH, Tsang VC, Garcia HH, Wilkins PP, , 2014. Recombinant protein- and synthetic peptide-based immunoblot test for diagnosis of neurocysticercosis. J Clin Microbiol 52: 14291434. [Google Scholar]
  13. Corstjens PL, de Dood CJ, Priest JW, Tanke HJ, Handali S, Cysticercosis Working Group in Peru; , 2014. Feasibility of a lateral flow test for neurocysticercosis using novel up-converting nanomaterials and a lightweight strip analyzer. PLoS Negl Trop Dis 8: e2944. [Google Scholar]
  14. Handali S, 2010. Development and evaluation of a magnetic immunochromatographic test to detect Taenia solium, which causes taeniasis and neurocysticercosis in humans. Clin Vaccine Immunol 17: 631637. [Google Scholar]
  15. Handali S, 2010. Multiantigen print immunoassay for comparison of diagnostic antigens for Taenia solium cysticercosis and taeniasis. Clin Vaccine Immunol 17: 6872. [Google Scholar]
  16. Goodhew EB, Priest JW, Moss DM, Zhong G, Munoz B, Mkocha H, Martin DL, West SK, Gaydos C, Lammie PJ, , 2012. CT694 and pgp3 as serological tools for monitoring trachoma programs. PLoS Negl Trop Dis 6: e1873. [Google Scholar]
  17. Moss DM, Chard AN, Trinies V, Doumbia S, Freeman MC, Lammie PJ, , 2017. Serological responses to filarial antigens in Malian children attending elementary schools. Am J Trop Med Hyg 96: 229232. [Google Scholar]
  18. Kulldorf M, , 1997. A spatial scan statistic. Commun Stat Theory 26: 14811496. [Google Scholar]
  19. Kulldorf MaIMS, Inc., 2015. SaTScanTM v9.4: Software for the Spatial and Space-Time Scan Statistics. Available at: http://www.satscan.org/. Accessed June 12, 2017.
  20. Coulibaly YI, 2015. The impact of six annual rounds of mass drug administration on Wuchereria bancrofti infections in humans and in mosquitoes in Mali. Am J Trop Med Hyg 93: 356360. [Google Scholar]
  21. Maiga YDM, Bouteille B, Konate A, Diarra M, Maiga M, Marjolet M, , 2009. A propos d’un cas autochtone de neurocysticercose au Mali (premier cas de la litterature?). Bull Soc Pathol Exot 102: 211214. [Google Scholar]
  22. Bureau of Democracy HR, and Labor, 2010. International Religious Freedom Report, 2010. Available at: https://www.state.gov/j/drl/rls/irf/2010/148665.htm. Accessed October 10, 2017.
  23. (OCHA) UNOftCoHA, 2013. Mali: Complex Emergency, Situation Report No. 39. Available at: https://reliefweb.int/sites/reliefweb.int/files/resources/Sitrep39_EN.pdf. Accessed September 12, 2017.
  24. Kellar KL, Kalwar RR, Dubois KA, Crouse D, Chafin WD, Kane BE, , 2001. Multiplexed fluorescent bead-based immunoassays for quantitation of human cytokines in serum and culture supernatants. Cytometry 45: 2736. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.17-0310
Loading
/content/journals/10.4269/ajtmh.17-0310
Loading

Data & Media loading...

  • Received : 13 Apr 2017
  • Accepted : 23 Jan 2018
  • Published online : 26 Mar 2018

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error