1921
Volume 97, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract.

The increasing shortage of organs for transplantation has prompted transplant programs to investigate the use of extended criteria donors, such as those with transmissible infectious diseases. Successful cases of organ transplantation (mostly kidney and liver) from seropositive donors to seronegative recipients have been reported. We present a case of lung transplantation from a donor serologically positive for Chagas disease to a seronegative recipient, and provide a review of the literature. Left single lung transplantation was performed in a 44-year-old Spanish woman presenting with interstitial lung disease in February 2016. The deceased donor was a Colombian immigrant living in Spain who was serologically positive for Chagas disease. Oral administration of 5 mg/kg/day benznidazole divided in three doses for 60 days was given for specific Chagas disease prophylaxis after transplantation. Periodic follow-up with serological reverse transcription polymerase chain reaction to detect DNA were performed until 6 months after the end of treatment. All results were negative, indicating that transmission of had not occurred. In a review of the literature, two similar cases were identified in Argentina and the United States. In both cases infection was detected posttransplant in the recipients, after which they were treated with benznidazole. The course of the patient described herein confirms that lungs from donors with chronic infection can be used successfully as allografts, and that posttransplant prophylaxis with benznidazole may reduce the probability of transmission of to the recipient.

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/content/journals/10.4269/ajtmh.17-0156
2017-10-11
2017-11-24
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  • Received : 27 Feb 2017
  • Accepted : 10 May 2017

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