1921
Volume 99, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Adult T-cell Leukemia/Lymphoma (ATLL) is a sight- and life-threatening complication of human T-cell lymphotropic virus type 1 (HTLV-1) infection. Ophthalmic manifestations include uveitis, optic nerve oedema, retinal vasculitis, and lymphomatous infiltration. Orbital lesions are rare. We report the case of an orbital tumor revealing systemic ATLL in a 45-year-old Dominican patient who died despite treatment. Apart from late-grade cutaneous T-cell lymphoma, ATLL is the only T-lymphoma to develop in the orbit. Diagnosis is based on serologic evidence of HTLV-1 infection, cytology, and blood sample analysis. Biopsy is deemed necessary. Given the poor prognosis of ATLL and the worldwide presentation of HTLV-1, physicians should consider ATLL in the differential diagnosis of orbital malignant tumor and look for HTLV-1 infection in populations at risk.

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References

  1. de Thé G, Kazanji M, , 1996. An HTLV-I/II vaccine: from animal models to clinical trials? J Acquir Immune Defic Syndr Hum Retrovirol 13 (Suppl 1): S191S198. [Google Scholar]
  2. Gessain A, Cassar O, , 2012. Epidemiological aspects and world distribution of HTLV-1 infection. Front Microbiol 3: 388. [Google Scholar]
  3. Ohba N, Nakao K, Isashiki Y, Kaminagayoshi T, Sonoda S, Yashiki S, Osame M, , 1994. Clinical features of HTLV-I associated uveitis determined in multicenter collaborative study. Study group for HTLV-I associated ocular diseases. Jpn J Ophthalmol 38: 168174. [Google Scholar]
  4. Pinheiro SRAA, Martins-Filho OA, Ribas JGR, Catalan-Soares BC, Proietti FA, Namen-Lopes S, Brito-Melo GEA, Carneiro-Proietti ABF, GIPH (Interdisciplinary HTLV-I/II Research Group), , 2006. Immunologic markers, uveitis, and keratoconjunctivitis sicca associated with human T-cell lymphotropic virus type 1. Am J Ophthalmol 142: 811815. [Google Scholar]
  5. Merle H, Cabre P, Merle S, Gerard M, Smadja D, , 2001. A description of human T-lymphotropic virus type I-related chronic interstitial keratitis in 20 patients. Am J Ophthalmol 131: 305308. [Google Scholar]
  6. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, de Thé G, , 1985. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet Lond Engl 2: 407410. [Google Scholar]
  7. Verdonck K, González E, Van Dooren S, Vandamme A-M, Vanham G, Gotuzzo E, , 2007. Human T-lymphotropic virus 1: recent knowledge about an ancient infection. Lancet Infect Dis 7: 266281. [Google Scholar]
  8. Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y, , 2010. Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan. J Med Virol 82: 668674. [Google Scholar]
  9. Shimoyama M, , 1991. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984–87). Br J Haematol 79: 428437. [Google Scholar]
  10. Shibata K, Shimamoto Y, Nishimura T, Okinami S, Yamada H, Miyahara M, , 1997. Ocular manifestations in adult T-cell leukemia/lymphoma. Ann Hematol 74: 163168. [Google Scholar]
  11. Yamamoto N, Kiyosawa M, Kawasaki T, Miki T, Fujino T, Tokoro T, , 1994. Successfully treated optic nerve infiltration with adult T-cell lymphoma. J Neuroophthalmol 14: 8183. [Google Scholar]
  12. Levy-Clarke GA, Buggage RR, Shen D, Vaughn LO, Chan C-C, Davis JL, , 2002. Human T-cell lymphotropic virus type-1 associated t-cell leukemia/lymphoma masquerading as necrotizing retinal vasculitis. Ophthalmology 109: 17171722. [Google Scholar]
  13. Merle H, Hage R, Meniane J-C, Deligny C, Plumelle Y, Donnio A, Jean-Charles A, , 2016. Retinal manifestations in adult T-cell leukemia/lymphoma related to infection by the human T-cell lymphotropic virus type-1. Retina 36: 13641371. [Google Scholar]
  14. Ohba N, Matsumoto M, Sameshima M, Kabayama Y, Nakao K, Unoki K, Uehara F, Kawano K, Maruyama I, Osame M, , 1989. Ocular manifestations in patients infected with human T-lymphotropic virus type I. Jpn J Ophthalmol 33: 112. [Google Scholar]
  15. Lauer SA, Fischer J, Jones J, Gartner S, Dutcher J, Hoxie JA, , 1988. Orbital T-cell lymphoma in human T-cell leukemia virus-I infection. Ophthalmology 95: 110115. [Google Scholar]
  16. Mori A, Deguchi HE, Mishima K, Kitaoka T, Amemiya T, , 2003. A case of uveal, palpebral, and orbital invasions in adult T-Cell leukemia. Jpn J Ophthalmol 47: 599602. [Google Scholar]
  17. Yoshikawa T, Ogata N, Takahashi K, Mori S, Uemura Y, Matsumura M, , 2005. Bilateral orbital tumor as initial presenting sign in human T-cell leukemia virus-1 associated adult T-cell leukemia/lymphoma. Am J Ophthalmol 140: 327329. [Google Scholar]
  18. Esmaeli B, Medeiros LJ, Myers J, Champlin R, Singh S, Ginsberg L, , 2001. Orbital mass secondary to precursor T-cell acute lymphoblastic leukemia: a rare presentation. Arch Ophthalmol 119: 443446. [Google Scholar]
  19. Shields JA, Shields CL, Scartozzi R, , 2004. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery lecture, part 1. Ophthalmology 111: 9971008. [Google Scholar]
  20. Isaacson P, Wright DH, , 1983. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer 52: 14101416. [Google Scholar]
  21. Murphy EL, Hanchard B, Figueroa JP, Gibbs WN, Lofters WS, Campbell M, Goedert JJ, Blattner WA, , 1989. Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I. Int J Cancer 43: 250253. [Google Scholar]
  22. Maguer-Satta V, Gazzolo L, Dodon MD, , 1995. Human immature thymocytes as target cells of the leukemogenic activity of human T-cell leukemia virus type I. Blood 86: 14441452. [Google Scholar]
  23. Alvarez C, Gotuzzo E, Vandamme A-M, Verdonck K, , 2016. Family aggregation of human T-lymphotropic virus 1-associated diseases: a systematic review. Front Microbiol 7: 1674. [Google Scholar]
  24. Kohno T, Uchida H, Inomata H, Fukushima S, Takeshita M, Kikuchi M, , 1993. Ocular manifestations of adult T-cell leukemia/lymphoma. A clinicopathologic study. Ophthalmology 100: 17941799. [Google Scholar]
  25. Fukushima T, ., 2005. Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma. Leukemia 19: 829834. [Google Scholar]
  26. Larson TA, Hu M, Janik JE, Nussenblatt RB, Morris JC, Sen HN, , 2012. Interleukin-2 receptor targeted therapy of ocular disease of HTLV-1-associated adult T-cell leukemia. Ocul Immunol Inflamm 20: 312314. [Google Scholar]
  27. Matsushita K, Matsumoto T, Ohtsubo H, Fujiwara H, Imamura N, Hidaka S, Kukita T, Tei C, Matsumoto M, Arima N, , 1999. Long-term maintenance combination chemotherapy with OPEC/MPEC (vincristine or methotrexate, prednisolone, etoposide and cyclophosphamide) or with daily oral etoposide and prednisolone can improve survival and quality of life in adult T-cell leukemia/lymphoma. Leuk Lymphoma 36: 6775. [Google Scholar]
  28. Nicot C, , 2005. Current views in HTLV-I-associated adult T-cell leukemia/lymphoma. Am J Hematol 78: 232239. [Google Scholar]
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  • Received : 21 Feb 2017
  • Accepted : 08 Aug 2017
  • Published online : 02 Jul 2018

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