Volume 97, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Dengue virus infection in human immunodeficiency virus (HIV)-positive patients is not well studied. Previous reports suggest a transitory inhibition of the HIV-1 viral load, as well as a benign clinical progression of dengue. The follow-up of six HIV-1-infected patients, diagnosed and hospitalized with dengue virus infection in the State of Colima, Mexico, was carried out to analyze the progression of this viral coinfection. The presence of dengue virus serotype 1 was confirmed through molecular tests. No severe complications were observed in any of the patients during dengue virus infection. Significant alteration of the HIV-1 viral loads was not observed during dengue virus infection and 6 months after coinfection. Further studies are required to understand the pathology, as well as the clinical course, of these viral coinfections.


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  1. González R, Ataíde R, Naniche D, Menéndez C, Mayor A, , 2012. HIV and malaria interactions: where do we stand? Expert Rev Anti Infect Ther 10: 153165. [Google Scholar]
  2. Rocha A, de Meneses AC, da Silva AM, Ferreira MS, Nishioka SA, Burgarelli MK, Almeida E, Turcato Júnior G, Metze K, Lopes ER, , 1994. Pathology of patients with Chagas disease and acquired immunodeficiency syndrome. Am J Trop Med Hyg 50: 261268. [Google Scholar]
  3. Morgado MG, Barcellos C, Pina MF, Bastos FI, , 2000. Human immunodeficiency virus/acquired immunodeficiency syndrome and tropical diseases: a Brazilian perspective. Mem Inst Oswaldo Cruz 95: 145151. [Google Scholar]
  4. Karp CL, Auwaerter PG, , 2007. Coinfection with HIV and tropical diseases. II. Helminthic, fungal, bacterial, and viral pathogens. Clin Infect Dis 45: 12141220. [Google Scholar]
  5. Baggio-Zappia GL, Hernandes GCF, , 2009. HIV-GB virus C co-infection: an overview. Clin Chem Lab Med 47: 1219. [Google Scholar]
  6. Watt G, Kantipong P, Jongsakul K, , 2003. Decrease in human immunodeficiency virus type 1 load during acute dengue fever. Clin Infect Dis 36: 10671069. [Google Scholar]
  7. Xiang J, McLinden JH, Rydze RA, Chang Q, Kaufman TM, Klinzman D, Stapleton JT, , 2009. Viruses within the Flaviviridae decrease CD4 expression and inhibit HIV replication in human CD4+ cells. J Immunol 183: 78607869. [Google Scholar]
  8. Gonzalez D, Limonta D, Bandera JF, Perez J, Kouri G, Guzman MG, , 2009. Dual infection with dengue virus 3 and human immunodeficiency virus 1 in Havana, Cuba. J Infect Dev Ctries 3: 318320. [Google Scholar]
  9. Siong WC, Ching TH, Jong GC, Pang CS, Vernon LJ, Sin LY, , 2008. Dengue infections in HIV patients. Southeast Asian J Trop Med Public Health 39: 260265. [Google Scholar]
  10. Mendes Wda S, Branco Mdos R, Medeiros MN, , 2006. Clinical case report: dengue hemorrhagic fever in a patient with acquired immunodeficiency syndrome. Am J Trop Med Hyg 74: 905907. [Google Scholar]
  11. Delgado-Enciso I, Espinoza-Gómez F, Ochoa-Jiménez R, Valle-Reyes S, Vásquez C, López-Lemus UA, , 2016. Dengue infection in a human immunodeficiency virus-1 positive patient chronically infected with hepatitis B virus in western Mexico. Am J Trop Med Hyg 96: 122125. [Google Scholar]
  12. Pang J, Thein TL, Lye DC, Leo YS, , 2015. Differential clinical outcome of dengue infection among patients with and without HIV infection: a matched case-control study. Am J Trop Med Hyg 92: 11561162. [Google Scholar]
  13. Torrentes-Carvalho A, Hottz ED, Marinho CF, da Silva JB, de Oliveira Pinto LM, Fialho LG, Bozza FA, Cunha RV, Damasco PV, Kubelka CF, de Azeredo EL, , 2016. Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV. Clin Immunol 164: 95105. [Google Scholar]
  14. Ayers M, Adachi D, Johnson G, Andonova M, Drebot M, Tellier R, , 2006. A single tube RT-PCR assay for the detection of mosquito-borne flaviviruses. J Virol Methods 135: 235239. [Google Scholar]
  15. Law WP, Duncombe CJ, Mahanontharit A, Boyd MA, Ruxrungtham K, Lange JM, Phanuphak P, Cooper DA, Dore GJ, , 2004. Impact of viral hepatitis co-infection on response to antiretroviral therapy and HIV disease progression in the HIV-NAT cohort. AIDS 18: 11691177. [Google Scholar]
  16. Malavige GN, Huang LC, Salimi M, Gomes L, Jayaratne SD, Ogg GS, , 2012. Cellular and cytokine correlates of severe dengue infection. PLoS One 7: e50387. [Google Scholar]
  17. Perez-Ramirez G, Diaz-Badillo A, Camacho-Nuez M, Cisneros A, Munoz M de L, , 2009. Multiple recombinants in two dengue virus, serotype-2 isolates from patients from Oaxaca, Mexico. BMC Microbiol 9: 260. [Google Scholar]
  18. López-Lemus UA, Vásquez C, Vázquez-Campuzano R, Valle-Reyes S, Guzmán-Bracho C, Araiza-Garaygordobil D, Rebolledo-Prudencio N, Delgado-Enciso I, Espinoza-Gómez F, 2014. Dengue virus serotype 1 non-structural protein NS5 expression interferes with HIV replication in a CD4+ T-cell line. Am J Trop Med Hyg 90: 418421. [Google Scholar]
  19. McLinden JH, Stapleton JT, Chang Q, Xiang J, , 2008. Expression of the dengue virus type 2 NS5 protein in a CD4(+) T cell line inhibits HIV replication. J Infect Dis 198: 860863. [Google Scholar]
  20. Chang Q, McLinden JH, Stapleton JT, Aslam SM, Xiang J, , 2007. Expression of GB virus C NS5A protein from genotypes 1, 2, 3 and 5 and a 30 aa NS5A fragment inhibit human immunodeficiency virus type 1 replication in a CD4+ T-lymphocyte cell line. J Gen Virol 88: 33413346. [Google Scholar]
  21. Xiang J, McLinden JH, Chang Q, Kaufman TM, Stapleton JT, , 2006. An 85-aa segment of the GB virus type C NS5A phosphoprotein inhibits HIV-1 replication in CD4+ Jurkat T cells. Proc Natl Acad Sci USA 103: 1557015575. [Google Scholar]

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  • Received : 16 Feb 2017
  • Accepted : 23 Apr 2017
  • Published online : 12 Jun 2017

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