1921
Volume 97, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus that was identified to be the etiological pathogen of the emerging infectious disease, severe fever with thrombocytopenia syndrome (SFTS). SFTSV could be transmitted through tick bite. Transmission of SFTSV among humans has also been reported mainly through direct blood contact. In July 2014, a cluster of six suspected SFTS cases occurred in Shandong Province, China. In this cluster, both symptomatic and asymptomatic persons were included. By analyzing the clinical data and results of laboratory tests, and conducting the epidemiological interviews with the cases and their families, risk factors responsible for the transmission were evaluated. The findings suggested that SFTSV transmission among humans may cause asymptomatic infection via personal contact without blood exposure.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.17-0059
2017-05-30
2019-11-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/97/2/tpmd170059.html?itemId=/content/journals/10.4269/ajtmh.17-0059&mimeType=html&fmt=ahah

References

  1. Yu XJ, ., 2011. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 364: 15231532.[Crossref] [Google Scholar]
  2. Jiang XL, ., 2014. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect 21: 274279.[Crossref] [Google Scholar]
  3. Zhang YZ, ., 2011. Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China. Zhonghua Liu Xing Bing Xue Za Zhi 32: 209220. [Google Scholar]
  4. Zhang YZ, ., 2012. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol 86: 28642868.[Crossref] [Google Scholar]
  5. Tang X, ., 2013. Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood. J Infect Dis 207: 736739.[Crossref] [Google Scholar]
  6. Bao CJ, ., 2011. A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission. Clin Infect Dis 53: 12081214.[Crossref] [Google Scholar]
  7. Wang Y, Deng B, Zhang J, Cui W, Yao W, Liu P, , 2014. Person-to-person asymptomatic infection of severe fever with thrombocytopenia syndrome virus through blood contact. Intern Med 53: 903906.[Crossref] [Google Scholar]
  8. Gai Z, ., 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis 54: 249252.[Crossref] [Google Scholar]
  9. Jiang XL, ., 2015. A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China. Clin Microbiol Infect 21: 274279.[Crossref] [Google Scholar]
  10. Liu Y, Li Q, Hu W, Wu J, Wang Y, Mei L, Walker DH, Ren J, Wang Y, Yu XJ, , 2012. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis 12: 156160.[Crossref] [Google Scholar]
  11. Chen H, Hu K, Zou J, Xiao J, , 2013. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis 17: e206e208.[Crossref] [Google Scholar]
  12. Kim WY, ., 2015. Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea. Clin Infect Dis 60: 16811683.[Crossref] [Google Scholar]
  13. Yoo JR, Heo ST, Park D, Kim H, Fukuma A, Fukushi S, Shimojima M, Lee KH, , 2016. Family cluster analysis of severe fever with thrombocytopenia syndrome virus infection in Korea. Am J Trop Med Hyg 95: 13511357.[Crossref] [Google Scholar]
  14. Bowen MD, Trappier SG, Sanchez AJ, Meyer RF, Goldsmith CS, Zaki SR, Dunster LM, Peters CJ, Ksiazek TG, Nichol ST, Force RVFT, , 2001. A reassortant bunyavirus isolated from acute hemorrhagic fever cases in Kenya and Somalia. Virology 291: 185190.[Crossref] [Google Scholar]
  15. Xu BL, ., 2011. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new Bunyavirus. PLoS Pathog 7: e1002369.[Crossref] [Google Scholar]
  16. Ning YJ, Wang M, Deng M, Shen S, Liu W, Cao WC, Deng F, Wang YY, Hu Z, Wang H, , 2014. Viral suppression of innate immunity via spatial isolation of TBK1/IKKepsilon from mitochondrial antiviral platform. J Mol Cell Biol 6: 324337.[Crossref] [Google Scholar]
  17. Shen S, Wang M, Li X, Li S, van Oers MM, Vlak JM, Braakman I, Hu Z, Deng F, Wang H, , 2016. Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus. J Gen Virol 97: 988999.[Crossref] [Google Scholar]
  18. Deitch EA, , 1992. Multiple organ failure. Pathophysiology and potential future therapy. Ann Surg 216: 117134.[Crossref] [Google Scholar]
  19. Gai ZT, ., 2012. Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients. J Infect Dis 206: 10951102.[Crossref] [Google Scholar]
  20. Zhang YZ, ., 2012. Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis 54: 527533.[Crossref] [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.17-0059
Loading
/content/journals/10.4269/ajtmh.17-0059
Loading

Data & Media loading...

Supplemental Figure and Table

  • Received : 25 Jan 2017
  • Accepted : 31 Mar 2017
  • Published online : 30 May 2017

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error