1921
Volume 97, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We examined burden and factors associated with norovirus (NoV) acute gastroenteritis (AGE) among children in rural Guatemala. Children age 6 weeks to 17 years were enrolled into three AGE surveillance groups, using two-stage cluster sampling: a prospective participatory syndromic surveillance (PSS) cohort and two cross-sectional rapid active sampling (RAS) surveys, conducted from April 2015 to February 2016. Epidemiologic and NoV testing data were used to identify factors associated with NoV infection, AGE, and NoV+ AGE. The three cross-sectional surveys (PSS enrollment visit, RAS Survey 1, and RAS Survey 2) enrolled 1,239 children, who reported 134 (11%) AGE cases, with 20% of AGE and 11% of non-AGE samples positive for NoV. Adjusted analyses identified several modifiable factors associated with AGE and NoV infection. The cross-sectional RAS surveys were practical and cost-effective in identifying population-level risk factors for AGE and NoV, supporting their use as a tool to direct limited public health resources toward high-risk populations.

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2017-09-07
2018-11-20
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References

  1. Lopman BA, Steele D, Kirkwood CD, Parashar UD, , 2016. The vast and varied global burden of norovirus: prospects for prevention and control. PLoS Med 13: e1001999.
  2. Lopman BA, , 2015. Global Burden of Norovirus and Prospects for Vaccine Development. Atlanta, GA: Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/norovirus/downloads/global-burden-report.pdf. Accessed October 5, 2016.
  3. de Graaf M, van Beek J, Koopmans MP, , 2016. Human norovirus transmission and evolution in a changing world. Nat Rev Microbiol 14: 421433.
  4. Riddle MS, Walker RI, , 2016. Status of vaccine research and development for norovirus. Vaccine 34: 28952899.
  5. Bernstein DI, ., 2015. Norovirus vaccine against experimental human GII.4 virus illness: a challenge study in healthy adults. J Infect Dis 211: 870878.
  6. Olson D, Lamb MM, Lopez MR, Paniagua-Avila MA, Zacarias A, Samayoa-Reyes G, Cordon-Rosales C, Asturias EJ, , 2017. A rapid epidemiological tool to measure the burden of norovirus infection and disease in resource-limited settings. Open Forum Infect Dis. https://doi.org/10.1093/ofid/ofx049.
  7. D’Ardenne KK, Darrow J, Furniss A, Chavez C, Hernandez H, Berman S, Asturias EJ, , 2016. Use of rapid needs assessment as a tool to identify vaccination delays in Guatemala and Peru. Vaccine 34: 17191725.
  8. Lanata CF, Black RE, , 1991. Lot quality assurance sampling techniques in health surveys in developing countries: advantages and current constraints. World Health Stat Q 44: 133139.
  9. Asturias EJ, ., 2016. The Center for Human Development in Guatemala: an innovative model for global population health. Adv Pediatr 63: 357387.
  10. Goldfarb DM, ., 2014. Evaluation of anatomically designed flocked rectal swabs for molecular detection of enteric pathogens in children admitted to hospital with severe gastroenteritis in Botswana. J Clin Microbiol 52: 39223927.
  11. Arvelo W, Hall AJ, Estevez A, Lopez B, Gregoricus N, Vinje J, Gentsch JR, Parashar U, Lindblade KA, , 2013. Diagnostic performance of rectal swab versus bulk stool specimens for the detection of rotavirus and norovirus: implications for outbreak investigations. J Clin Virol 58: 678682.
  12. Trujillo AA, McCaustland KA, Zheng DP, Hadley LA, Vaughn G, Adams SM, Ando T, Glass RI, Monroe SS, , 2006. Use of TaqMan real-time reverse transcription-PCR for rapid detection, quantification, and typing of norovirus. J Clin Microbiol 44: 14051412.
  13. Van Damme P, Giaquinto C, Huet F, Gothefors L, Maxwell M, Van der Wielen M, , 2007. Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004–2005: the REVEAL study. J Infect Dis 195 (Suppl 1): S4S16.
  14. Eisenhauer IF, Hoover CM, Remais JV, Monaghan A, Celada M, Carlton EJ, , 2016. Estimating the risk of domestic water source contamination following precipitation events. Am J Trop Med Hyg 94: 14031406.
  15. Raphael K, , 1987. Recall bias: a proposal for assessment and control. Int J Epidemiol 16: 167170.
  16. Estevez A, ., 2013. Prevalence and genetic diversity of norovirus among patients with acute diarrhea in Guatemala. J Med Virol 85: 12931298.
  17. Rouhani S, ., 2016. Norovirus infection and acquired immunity in 8 countries: results from the MAL-ED study. Clin Infect Dis 62: 12101217.
  18. Platts-Mills JA, ., 2015. Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED). Lancet Glob Health 3: e564e575.
  19. Kotloff KL, ., 2013. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet 382: 209222.
  20. Liu J, ., 2016. Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study. Lancet 388: 12911301.
  21. O’Ryan M, Riera-Montes M, Lopman B, , 2016. Norovirus in Latin America: systematic review and meta-analysis. Pediatr Infect Dis J 36: 127134.
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  • Received : 19 Dec 2016
  • Accepted : 02 Mar 2017

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