1921
Volume 97, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

During the past two decades, there has been a dramatic increase in the recognition and characterization of novel insect-specific flaviviruses (ISFVs). Some of these agents are closely related to important mosquito-borne flavivirus pathogens. Results of experimental studies suggest that mosquitoes and mosquito cell cultures infected with some ISFVs are refractory to superinfection with related flavivirus pathogens; and it has been proposed that ISFVs potentially could be used to alter the vector competence of mosquitoes and reduce transmission of specific flavivirus pathogens, such as dengue, West Nile, or Zika viruses. In order for an ISFV to be used in such a control strategy, the virus would have to be vertically transmitted at a high rate in the target vector population to insure its continued maintenance. This study compared the vertical transmission rates of an ISFV, cell fusing agent virus (CFAV), in two colonies: one naturally infected with CFAV and the other experimentally infected but previously free of the virus. CFAV filial infection rates in progeny of female mosquitoes from both colonies were > 90% after two generations of selection, indicating the feasibility of introducing an ISFV into a mosquito population. This and other considerations for evaluating the feasibility of using ISFVs as an arbovirus control strategy are discussed.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.16-0987
2017-07-12
2018-09-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/97/1/tpmd160987.html?itemId=/content/journals/10.4269/ajtmh.16-0987&mimeType=html&fmt=ahah

References

  1. Stollar V, Thomas VL, , 1975. An agent in the Aedes aegypti cell line (Peleg) which causes fusion of Aedes albopictus (Singh) cells. Virology 47: 122132.[Crossref]
  2. Peleg J, , 1969. Inapparent persistent virus infection in continuously grown Aedes aegypti mosquito cells. J Gen Virol 5: 463471.[Crossref]
  3. Singh KRP, , 1967. Cell cultures derived from larvae of Aedes albopictus (Skusex) and Aedes aegypti (L.). Curr Sci 36: 506508.
  4. Igarashi A, Harrap KA, Casals J, Stollar V, , 1976. Morphological, biochemical, and serological studies on a viral agent (CFA) which replicates in and causes fusion of Aedes albopictus (Singh) cells. Virology 74: 174187.[Crossref]
  5. Cammisa-Parks H, Cisar LA, Kane A, Stollar V, , 1976. The complete nucleotide sequence of cell fusing agent (CFA): homology between the nonstructural proteins encoded by CFA and the nonstructural proteins encoded by arthropod-borne flaviviruses. Virology 189: 511524.[Crossref]
  6. Cook S, Bennett SN, Holmes EC, Chesse RD, Moureau G, de Lamballerie X, , 2006. Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico. J Gen Virol 87: 725748.[Crossref]
  7. Calzolari M, Ze-Ze L, Vasquez A, Sanchez Seco MP, Amaro F, Dottori M, , 2016. Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects. Infect Genet Evol 40: 381388.[Crossref]
  8. Yamanaka A, Thongrungkiat S, Ramasoota P, Konishi E, , 2013. Genetic and evolutionary analysis of cell-fusing agent virus based on Thai strains isolated in 2008 and 2012. Infect Genet Evol 19: 188194.[Crossref]
  9. Hoshino K, Isawa H, Tsuda Y, Sawabe K, Kobayashi M, , 2009. Isolation and characterization of a new insect flavivirus from Aedes albopictus and Aedes flavopictus mosquitoes in Japan. Virology 391: 119129.[Crossref]
  10. Espinoza-Gomez F, Lopez-Lemus AU, Rodriguez-Sanchez IP, Martinez-Fierro ML, Newton-Sanchez OA, Chavez-Flores E, Delgado-Enciso I, , 2011. Detection of sequences from a potentially novel strain of cell fusing agent virus in Mexican Stegomyia (Aedes) aegypti mosquitoes. Arch Virol 156: 12631267.[Crossref]
  11. Bolling BG, Vasilakis N, Guzman H, Widen SG, Wood TG, Popov VL, Thangamani S, Tesh RB, , 2015. Insect-specific viruses detected in laboratory mosquito colonies and their potential implications for experiments evaluating arbovirus vector competence. Am J Trop Med Hyg 92: 422428.[Crossref]
  12. Collao X, Prado L, Gonzalez C, Vasquez A, Araki R, Henriquez T, Pena CM, , 2015. Detection of flavivirus in mosquitoes (Diptera: Culicidae) from Easter Island-Chile. Rev Chilena Infectol 32: 113116.[Crossref]
  13. Bolling BG, Weaver SC, Tesh RB, Vasilakis N, , 2015. Insect-specific virus discovery: significance for the arbovirus community. Viruses 7: 49114928.[Crossref]
  14. World Health Organization, 1985. Arthropod-Borne and Rodent-Borne Viral Diseases. WHO Tech Report Series 719. Geneva, Switzerland: World Health Organization.
  15. Datta S, Gopalakrishnan R, Chatterjee S, Veer V, , 2015. Phylogenetic characterization of a novel insect-specific flavivirus detected in a Culex pool, collected from Assam, India. Intervirology 58: 149154.[Crossref]
  16. Misencik MJ, Grubaugh ND, Andreadis TG, Ebel GD, Armstrong PM, , 2016. Isolation of a novel insect-specific Flavivirus from Culiseta melanura in the northeastern United States. Vector Borne Zoonotic Dis 16: 181190.[Crossref]
  17. Kuwata R, Sugiyama H, Yonemitsu K, Van Dung N, Terada Y, Taniguchi M, Shimoda H, Takano A, Maeda K, , 2015. Isolation of Japanese encephalitis virus and a novel insect-specific flavivirus from mosquitoes collected in a cowshed in Japan. Arch Virol 160: 21512159.[Crossref]
  18. Fan H, Zhao Q, Guo X, Sun Q, Zuo S, Wu C, Zhou H, An X, Pei G, Tong Y, Zhang J, Shi T, , 2016. Complete genome sequence of Xishuangbanna flavivirus, a novel mosquito-specific flavivirus from China. Arch Virol 161: 17231727.[Crossref]
  19. Cholleti H, Hayer J, Abilio AP, Mulandane FC, Verner-Carlsson J, Falk KI, Fafetine JM, Berg M, Blomstrom AL, , 2016. Discovery of novel viruses in mosquitoes from the Zambezi Valley of Mozambique. PLoS One 11: e0162751.[Crossref]
  20. Tesh RB, Bolling BG, Beaty BJ, Gubler DJ, Vasilakis N, , 2016. Role of vertical transmission in arbovirus maintenance and evolution. , eds. Arboviruses: Molecular Biology, Evolution and Control. Norfolk, United Kingdom: Calister Academic Press, 191218.[Crossref]
  21. Bolling BG, Eisen L, Moore CG, Blair CD, , 2011. Insect-specific flaviviruses from Culex mosquitoes in Colorado, with evidence of vertical transmission. Am J Trop Med Hyg 85: 169177.[Crossref]
  22. Saiyasombat R, Bolling BG, Brault AC, Bartholomay LC, Blitvich BJ, , 2011. Evidence of efficient transovarial transmission of Culex flavivirus by Culex pipiens (Diptera: Culicidae). J Med Entomol 48: 10311038.[Crossref]
  23. Vanlandingham DL, McGee CE, Klinger KA, Vessey N, Fredregillo C, Higgs S, , 2007. Short report: relative susceptibilities of South Texas mosquitoes to infection with West Nile virus. Am J Trop Med Hyg 77: 925928.
  24. Higgs S, Marquardt WC, , 2005. Care, maintenance, and experimental infection of mosquitoes. , ed. Biology of Disease Vectors, 2nd edition. Burlington, MA: Elsevier, 733739.
  25. Bolling BC, Olea-Papelka FJ, Eisen L, Moore CG, Blair CD, , 2012. Transmission dynamics of an insect-specific flavivirus in a naturally infected Culex pipiens laboratory colony and effects of co-infection on vector competence for West Nile virus. Virology 427: 9097.[Crossref]
  26. Hobson-Peters J, Yam AWY, Lu JWF, Setoh YX, May FJ, Kurucz N, Walsh S, Prow NA, Davis SS, Weir R, Melville L, Hunt N, Webb RI, Blitvich BJ, Whelan P, Hall RA, , 2013. A new insect-specific flavivirus from northern Australia suppresses replication of West Nile virus and Murray Valley encephalitis virus in co-infected mosquito cells. PLoS One 8: e56534.[Crossref]
  27. Kenney JL, Solberg OD, Langevin SA, Brault AC, , 2014. Characterization of a novel insect-specific flavivirus from Brazil: potential for inhibition of infection of arthropod cells with medically important flaviviruses. J Gen Virol 95: 27962808.[Crossref]
  28. Hall-Mendelin S, McLean BJ, Bielefeldt-Ohmann H, Hobson-Peters J, Hall RA, , 2016. The insect-specific Palm Creek virus modulates West Nile virus infection in and transmission by Australian mosquitoes. Parasit Vectors 9: 414.[Crossref]
  29. Goenaga S, Kenney JL, Duggal NK, Delorey M, Ebel GD, Zhang B, Levis SC, Enria DA, Brault AC, , 2015. Potential for co-infection of a mosquito-specific flavivirus, Nhumirim virus, to block West Nile virus transmission in mosquitoes. Viruses 7: 58015812.[Crossref]
  30. Scott JC, Brackney DE, Campbell CL, Bondu-Hawkins V, Hjelle B, Ebel GD, Olson KE, Blair CD, , 2010. Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -nocompetent mosquito cells. PLoS Negl Trop Dis 4: e848.[Crossref]
  31. Brackney DE, Scott JC, Sagawa F, Woodward JE, Miller NA, Schilkey FD, Mudge J, Wilusz J, Olson KE, Blair CD, Ebel GD, , 2010. C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS Negl Trop Dis 4: e856.[Crossref]
  32. Jupatanakul N, Dimopoulos G, Gubler DJ, Vasilakis N, , 2016. Molecular interactions between arboviruses and insect vectors: insects’ immune responses to virus infection. , eds. Arboviruses: Molecular Biology, Evolution and Control. Norwalk, United Kingdom: Calister Academic Press, 107118.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0987
Loading
/content/journals/10.4269/ajtmh.16-0987
Loading

Data & Media loading...

  • Received : 15 Dec 2016
  • Accepted : 03 Mar 2017

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error