1921
Volume 97, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We present a series of four pregnant women with Rocky Mountain spotted fever (RMSF) that occurred in Sonora, Mexico, during 2015–2016. Confirmatory diagnoses were made by polymerase chain reaction or serological reactivity to antigens of by using an indirect immunofluorescence antibody assay. Each patient presented with fever and petechial rash and was treated successfully with doxycycline. Each of the women and one full-term infant delivered at 36 weeks gestation survived the infection. Three of the patients in their first trimester of pregnancy suffered spontaneous abortions. RMSF should be suspected in any pregnant woman presenting with fever, malaise and rash in regions where is endemic.

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2017-09-07
2018-09-23
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References

  1. Dantas-Torres F, , 2007. Rocky Mountain spotted fever. Lancet Infect Dis 7: 724732.
  2. Biggs HM, , et al., 2016. Diagnosis and management of tick borne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis—United States: a practical guide for health care and public health professionals. MMWR Recomm Rep 65: 144.
  3. Álvarez-Hernández G, , 2010. La fiebre manchada de las Montañas Rocosas, una epidemia olvidada. Salud Publica Mex 52: 13.
  4. Masters E, , 2003. Rocky Mountain spotted fever: a clinician’s dilemma. Arch Intern Med 163: 769774.
  5. Stallings SP, , 2001. Rocky Mountain spotted fever and pregnancy: a case report and review of the literature. Obstet Gynecol Surv 56: 3742.
  6. Markley KC, Levine AB, Chan Y, , 1998. Rocky Mountain spotted fever in pregnancy. Obstet Gynecol 91: 860.
  7. Tribaldos M, , et al., 2011. Rocky Mountain spotted fever in Panama: a cluster description. J Infect Dev Ctries 5: 737747.
  8. Hidalgo L, , et al., 2007. Rocky Mountain spotted fever, Colombia. Emerg Infect Dis 13: 10581060.
  9. Hebert WNP, Seeds JW, Koontz WL, Cefalo RC, , 1982. Rocky Mountain spotted fever in pregnancy: differential diagnosis and treatment. South Med J 75: 10631066.
  10. Cohlan SQ, , 1977. Tetracycline staining of teeth. Teratology 15: 127129.
  11. Genot MT, Golan HP, Porter PJ, , 1970. Effect of administration of tetracycline in pregnancy on the primary dentition of the offspring. J Oral Med 25: 7579.
  12. Totterman LE, Saxen L, , 1969. Incorporation of tetracycline into human foetal bones after maternal drug administration. Acta Obstet Gynecol Scand 48: 542549.
  13. Cohlan SQ, Bevelander G, Tiamsic T, , 1963. Growth inhibition of prematures receiving tetracycline. Am J Dis Child 105: 454461.
  14. Labruna MB, Whitworth T, Horta MC, Bouyer DH, McBride JW, Pinter A, Popov V, Gennari SM, Walker DH, , 2004. Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of Sao Paulo, Brazil, where Brazilian spotted fever is endemic. J Clin Microbiol 42: 9098.
  15. Kato CY, Chung IH, Robinson LK, Austin AL, Dasch GA, Massung RF, , 2013. Assessment of Real-Time PCR assay for detection of Rickettsia spp. and Rickettsia rickettsii in banked clinical samples. J Clin Microbiol 51: 314317.
  16. de Lemos ER, , et al., 2001. Spotted fever in Brazil: a seroepidemiological study and description of clinical cases in an endemic area of the state of Sao Paulo. Am J Trop Med Hyg 65: 329334.
  17. Gallis HA, Agner C, Painter CJ, , 1984. Rocky Mountain spotted fever in pregnancy. N C Med J 45: 187188.
  18. Dalton MJ, Clarke MJ, Holman RC, Krebs JW, Fishbein JG, Olson JG, Childs JE, , 1995. National surveillance for Rocky Mountain spotted fever, 1981–1992: epidemiologic summary and evaluation of risk factors for fatal outcome. Am J Trop Med Hyg 52: 405413.
  19. Holman RC, Paddock CD, Curns AT, Krebs JW, McQuiston JH, Childs JE, , 2001. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence of superiority of tetracyclines for therapy. J Infect Dis 184: 14371444.
  20. Secretaría de Salud, 2013. Prevención, diagnóstico y tratamiento de la fiebre manchada por Rickettsia rickettsii en población pediátrica y adulta en el primer y segundo nivel de atención. Available at: http://www.cenetec.salud.gob.mx/descargas/gpc/CatalogoMaestro/SS_595_13_FIEBREMANCHADAROCKETSIA/SS_595_13_RER.pdf. Accessed June 25, 2016.
  21. Helmick CG, Bernard KW, D’Angelo LJ, , 1984. Rocky Mountain spotted fever: clinical, laboratory, and epidemiological characteristics of 262 cases. J Infect Dis 150: 480488.
  22. Traeger MS, , et al., 2015. Rocky Mountain spotted fever characterization and comparison to similar illnesses in a highly endemic area—Arizona, 2002–2011. Clin Infect Dis 60: 16501658.
  23. Secretaría de Salud, 2016. Clasificación, diagnóstico y tratamiento integral del dengue. Available at: http://www.cenetec.salud.gob.mx/descargas/gpc/CatalogoMaestro/151_GPC_DENGUE/SSA_151_08_EyR_Dengue_170310.pdf. Accessed June 25, 2016.
  24. Alvarez-Hernandez G, Murillo-Benitez C, Candia-Plata MC, Moro M, , 2015. Clinical profile and predictors of fatal Rocky Mountain spotted fever in children from Sonora, Mexico. Pediatr Infect Dis J 34: 125130.
  25. McGready R, , et al., 2014. Pregnancy outcome in relation to treatment of murine typhus and scrub typhus infection: a Fever cohort and a case series analysis. PLoS Negl Trop Dis 8: e3327.
  26. Walker DH, , 2007. Rickettsiae and rickettsial infections: the current state of knowledge. Clin Infect Dis 4S: S39S44.
  27. Bentov Y, Sheiner E, Kenigsberg S, Mazor M, , 2003. Mediterranean spotted fever in pregnancy: case report and literature review. Eur J Obstet Gyn Rep Biol 107: 214216.
  28. Walker DH, Ismail N, , 2008. Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events. Nat Rev Microbiol 6: 375386.
  29. Cross R, Ling C, Day NPJ, McGready R, Paris DH, , 2016. Revisiting doxycycline in pregnancy and early childhood–time to rebuild its reputation? Expert Opin Drug Saf 15: 367382.
  30. Federal Drug Administration, 2014. Federal Register, Part II. Available at: https://www.gpo.gov/fdsys/pkg/FR-2014-12-04/pdf/2014-28241.pdf. Accessed June 26, 2016.
  31. Todd SR, Dahlgren FS, Traeger MS, Beltran-Aguilar ED, Marianos DW, Hamilton C, McQuiston JH, Regan JJ, , 2015. No visible dental staining in children treated with doxycycline for suspected Rocky Mountain spotted fever. J Pediatr 166: 12461251.
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  • Received : 21 Nov 2016
  • Accepted : 01 May 2017

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