1921
Volume 97, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We present a series of four pregnant women with Rocky Mountain spotted fever (RMSF) that occurred in Sonora, Mexico, during 2015–2016. Confirmatory diagnoses were made by polymerase chain reaction or serological reactivity to antigens of by using an indirect immunofluorescence antibody assay. Each patient presented with fever and petechial rash and was treated successfully with doxycycline. Each of the women and one full-term infant delivered at 36 weeks gestation survived the infection. Three of the patients in their first trimester of pregnancy suffered spontaneous abortions. RMSF should be suspected in any pregnant woman presenting with fever, malaise and rash in regions where is endemic.

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References

  1. Dantas-Torres F, , 2007. Rocky Mountain spotted fever. Lancet Infect Dis 7: 724732. [Google Scholar]
  2. Biggs HM, , et al., 2016. Diagnosis and management of tick borne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis—United States: a practical guide for health care and public health professionals. MMWR Recomm Rep 65: 144. [Google Scholar]
  3. Álvarez-Hernández G, , 2010. La fiebre manchada de las Montañas Rocosas, una epidemia olvidada. Salud Publica Mex 52: 13. [Google Scholar]
  4. Masters E, , 2003. Rocky Mountain spotted fever: a clinician’s dilemma. Arch Intern Med 163: 769774. [Google Scholar]
  5. Stallings SP, , 2001. Rocky Mountain spotted fever and pregnancy: a case report and review of the literature. Obstet Gynecol Surv 56: 3742. [Google Scholar]
  6. Markley KC, Levine AB, Chan Y, , 1998. Rocky Mountain spotted fever in pregnancy. Obstet Gynecol 91: 860. [Google Scholar]
  7. Tribaldos M, , et al., 2011. Rocky Mountain spotted fever in Panama: a cluster description. J Infect Dev Ctries 5: 737747. [Google Scholar]
  8. Hidalgo L, , et al., 2007. Rocky Mountain spotted fever, Colombia. Emerg Infect Dis 13: 10581060. [Google Scholar]
  9. Hebert WNP, Seeds JW, Koontz WL, Cefalo RC, , 1982. Rocky Mountain spotted fever in pregnancy: differential diagnosis and treatment. South Med J 75: 10631066. [Google Scholar]
  10. Cohlan SQ, , 1977. Tetracycline staining of teeth. Teratology 15: 127129. [Google Scholar]
  11. Genot MT, Golan HP, Porter PJ, , 1970. Effect of administration of tetracycline in pregnancy on the primary dentition of the offspring. J Oral Med 25: 7579. [Google Scholar]
  12. Totterman LE, Saxen L, , 1969. Incorporation of tetracycline into human foetal bones after maternal drug administration. Acta Obstet Gynecol Scand 48: 542549. [Google Scholar]
  13. Cohlan SQ, Bevelander G, Tiamsic T, , 1963. Growth inhibition of prematures receiving tetracycline. Am J Dis Child 105: 454461. [Google Scholar]
  14. Labruna MB, Whitworth T, Horta MC, Bouyer DH, McBride JW, Pinter A, Popov V, Gennari SM, Walker DH, , 2004. Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of Sao Paulo, Brazil, where Brazilian spotted fever is endemic. J Clin Microbiol 42: 9098. [Google Scholar]
  15. Kato CY, Chung IH, Robinson LK, Austin AL, Dasch GA, Massung RF, , 2013. Assessment of Real-Time PCR assay for detection of Rickettsia spp. and Rickettsia rickettsii in banked clinical samples. J Clin Microbiol 51: 314317. [Google Scholar]
  16. de Lemos ER, , et al., 2001. Spotted fever in Brazil: a seroepidemiological study and description of clinical cases in an endemic area of the state of Sao Paulo. Am J Trop Med Hyg 65: 329334. [Google Scholar]
  17. Gallis HA, Agner C, Painter CJ, , 1984. Rocky Mountain spotted fever in pregnancy. N C Med J 45: 187188. [Google Scholar]
  18. Dalton MJ, Clarke MJ, Holman RC, Krebs JW, Fishbein JG, Olson JG, Childs JE, , 1995. National surveillance for Rocky Mountain spotted fever, 1981–1992: epidemiologic summary and evaluation of risk factors for fatal outcome. Am J Trop Med Hyg 52: 405413. [Google Scholar]
  19. Holman RC, Paddock CD, Curns AT, Krebs JW, McQuiston JH, Childs JE, , 2001. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence of superiority of tetracyclines for therapy. J Infect Dis 184: 14371444. [Google Scholar]
  20. Secretaría de Salud, 2013. Prevención, diagnóstico y tratamiento de la fiebre manchada por Rickettsia rickettsii en población pediátrica y adulta en el primer y segundo nivel de atención. Available at: http://www.cenetec.salud.gob.mx/descargas/gpc/CatalogoMaestro/SS_595_13_FIEBREMANCHADAROCKETSIA/SS_595_13_RER.pdf. Accessed June 25, 2016.
  21. Helmick CG, Bernard KW, D’Angelo LJ, , 1984. Rocky Mountain spotted fever: clinical, laboratory, and epidemiological characteristics of 262 cases. J Infect Dis 150: 480488. [Google Scholar]
  22. Traeger MS, , et al., 2015. Rocky Mountain spotted fever characterization and comparison to similar illnesses in a highly endemic area—Arizona, 2002–2011. Clin Infect Dis 60: 16501658. [Google Scholar]
  23. Secretaría de Salud, 2016. Clasificación, diagnóstico y tratamiento integral del dengue. Available at: http://www.cenetec.salud.gob.mx/descargas/gpc/CatalogoMaestro/151_GPC_DENGUE/SSA_151_08_EyR_Dengue_170310.pdf. Accessed June 25, 2016.
  24. Alvarez-Hernandez G, Murillo-Benitez C, Candia-Plata MC, Moro M, , 2015. Clinical profile and predictors of fatal Rocky Mountain spotted fever in children from Sonora, Mexico. Pediatr Infect Dis J 34: 125130. [Google Scholar]
  25. McGready R, , et al., 2014. Pregnancy outcome in relation to treatment of murine typhus and scrub typhus infection: a Fever cohort and a case series analysis. PLoS Negl Trop Dis 8: e3327. [Google Scholar]
  26. Walker DH, , 2007. Rickettsiae and rickettsial infections: the current state of knowledge. Clin Infect Dis 4S: S39S44. [Google Scholar]
  27. Bentov Y, Sheiner E, Kenigsberg S, Mazor M, , 2003. Mediterranean spotted fever in pregnancy: case report and literature review. Eur J Obstet Gyn Rep Biol 107: 214216. [Google Scholar]
  28. Walker DH, Ismail N, , 2008. Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events. Nat Rev Microbiol 6: 375386. [Google Scholar]
  29. Cross R, Ling C, Day NPJ, McGready R, Paris DH, , 2016. Revisiting doxycycline in pregnancy and early childhood–time to rebuild its reputation? Expert Opin Drug Saf 15: 367382. [Google Scholar]
  30. Federal Drug Administration, 2014. Federal Register, Part II. Available at: https://www.gpo.gov/fdsys/pkg/FR-2014-12-04/pdf/2014-28241.pdf. Accessed June 26, 2016.
  31. Todd SR, Dahlgren FS, Traeger MS, Beltran-Aguilar ED, Marianos DW, Hamilton C, McQuiston JH, Regan JJ, , 2015. No visible dental staining in children treated with doxycycline for suspected Rocky Mountain spotted fever. J Pediatr 166: 12461251. [Google Scholar]
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  • Received : 21 Nov 2016
  • Accepted : 01 May 2017

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