Volume 96, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Chagas disease (CD), with associated conduction abnormalities, is a common indication for pacemaker implantation in Latin America. The prevalence of CD in Latin American immigrants with pacemakers residing in the United States has never been studied. This single-center cross-sectional study included pacemaker patients who were aged 18 years or more with a previous residence in Latin America for at least 6 months. Patients with an implantable cardioverter-defibrillator, cardiac resynchronization therapy, or iatrogenic and/or congenital heart block were excluded. Serological testing for was performed at enrollment. A total of 80 patients were enrolled, and CD was diagnosed in six patients (7.5%). Patients with CD were more likely to be from El Salvador ( = 0.001). Other clinical, therapeutic, electrocardiographic, and echocardiographic variables were similar between the CD and non-CD groups. There is a high prevalence of CD among Latin American immigrants with pacemakers in Los Angeles.


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  1. Bern C, Montgomery SP, Herwaldt BL, Rassi A, Jr Marin-Neto JA, Dantas RO, Maguire JH, Acquatella H, Morillo C, Kirchhoff LV, Gilman RH, Reyes PA, Salvatella R, Moore AC, , 2007. Evaluation and treatment of Chagas disease in the United States: a systematic review. JAMA 298: 21712181.[Crossref] [Google Scholar]
  2. Rassi A, Marin-Neto JA, , 2010. Chagas disease. Lancet 375: 13881402.[Crossref] [Google Scholar]
  3. Andrade ZA, , 1983. Mechanisms of myocardial damage in Trypanosoma cruzi infection. Ciba Found Symp 99: 214233. [Google Scholar]
  4. Marin-Neto JA, Cunha-Neto E, Maciel BC, Simões MV, , 2007. Pathogenesis of chronic Chagas heart disease. Circulation 115: 11091123.[Crossref] [Google Scholar]
  5. Rincon LG, Rocha MO, Pires MT, Oliveira BG, Barros V da C, Barros MV, Ribeiro AL, , 2006. Clinical profile of Chagas and non-Chagas' disease patients with cardiac pacemaker [in Portugese]. Rev Soc Bras Med Trop 39: 245249.[Crossref] [Google Scholar]
  6. Costa R, Rassi A, Leão MI de P, , 2004. Clinical and epidemiological characteristics of patients with Chagas' disease submitted to permanent cardiac pacemaker implantation [in Portugese]. Rev Bras Cir Cardiovasc 19: 107114. [Google Scholar]
  7. World Health Organization, 2016. First WHO Report on Neglected Tropical Diseases: Working to Overcome the Global Impact of Neglected Tropical Diseases. Available at: http://apps.who.int/iris/bitstream/10665/44440/1/9789241564090_eng.pdf. Accessed October 1, 2016. [Google Scholar]
  8. Bern C, Montgomery SP, , 2009. An estimate of the burden of Chagas disease in the United States. Clin Infect Dis 49: e52e54.[Crossref] [Google Scholar]
  9. United States Census Bureau. Available at: https://factfinder.census.gov/faces/nav/jsf/pages/index.xhtml. Accessed October 1, 2016.
  10. Stramer S, , 2007. Blood Donor Screening for Chagas Disease—United States, 2006–2007. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5607a2.htm. Accessed October 1, 2016. [Google Scholar]
  11. Prineas RJ, Crow RS, , 2010. The Minnesota Code Manual of Electrocardiographic Findings: Standards and Procedures for Measurement and Classification, 2nd edition. London, United Kingdom: Springer.[Crossref] [Google Scholar]
  12. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt J-U, , 2015. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28: 139.[Crossref] [Google Scholar]
  13. Arce M, Van Grieken J, Femenia F, Arrieta M, Mcintyre WF, Baranchuk A, , 2012. Permanent pacing in patients with Chagas' disease. Pacing Clin Electrophysiol 35: 14941497.[Crossref] [Google Scholar]
  14. Oliveira BG, Velasquez-Melendez G, Rincón LG, Ciconelli RM, Sousa LA, Ribeiro AL, , 2008. Health-related quality of life in Brazilian pacemaker patients. Pacing Clin Electrophysiol 31: 11781183.[Crossref] [Google Scholar]
  15. Bustamante JM, Novarese M, Rivarola HW, Lo Presti MS, Fernández AR, Enders JE, Fretes R, Paglini-Oliva PA, , 2007. Reinfections and Trypanosoma cruzi strains can determine the prognosis of the chronic Chagasic cardiopathy in mice. Parasitol Res 100: 14071410.[Crossref] [Google Scholar]
  16. Dias J, Silveira A, Schofield C, , 2002. The impact of Chagas disease control in Latin America: a review. Mem Inst Oswaldo Cruz 97: 603612.[Crossref] [Google Scholar]
  17. Kuschnir E, Sgammini H, Castro R, Evequoz C, Ledesma R, Brunetto J, , 1985. Evaluation of cardiac function by radioisotopic angiography, in patients with chronic Chagas cardiopathy [in Spanish]. Arq Bras Cardiol 45: 249256. [Google Scholar]
  18. Viotti R, , 2006. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment. Ann Intern Med 144: 724734.[Crossref] [Google Scholar]
  19. Morillo CA, Marin-Neto JA, Avezum A, Sosa-Estani S, Rassi A, Jr Rosas F, Villena E, Quiroz R, Bonilla R, Britto C, Guhl F, Velazquez E, Bonilla L, Meeks B, Rao-Melacini P, Pogue J, Mattos A, Lazdins J, Rassi A, Connolly SJ, Yusuf S, , 2015. Randomized trial of benznidazole for chronic Chagas' cardiomyopathy. N Engl J Med 373: 12951306.[Crossref] [Google Scholar]

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  • Received : 21 Oct 2016
  • Accepted : 31 Jan 2017
  • Published online : 06 Mar 2017

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