Volume 98, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The incidence of dengue worldwide is increasing rapidly. A better understanding of dengue transmission may help improve interventions against this major public health problem. The virus is mostly transmitted by vectors. There are, however, other modes of transmission, notably mother-to-child transmission or vertical transmission. We studied a prospective cohort of 54 women who had dengue while pregnant during the 2012–2013 epidemic in French Guiana to estimate the mother-to-child transmission rate and assess the clinical and biological presentation of neonatal dengue. The rate of vertical transmission was between 18.5% (95% confidence interval [CI]: 9.25–31.4) and 22.7% (95% CI: 11.5–37.8), depending on the calculation method used. Mother-to-child transmission occurred both in early and late pregnancy. There were 52 births, including three newborns who presented neonatal dengue with warning signs requiring platelet transfusion. This quantification of the mother-to-child transmission of dengue highlights three points: first, vertical transmission of dengue is not negligible; second, it is more frequent when maternal dengue occurs late during pregnancy near delivery; and third, reliable diagnostic tests must be used to allow the diagnosis of vertical transmission. Our findings indicate that if there is a known history of maternal dengue during pregnancy, or if there is fever during the 15 days before term, cord blood and placenta should be sampled after delivery and tested for the virus, and the newborn should be closely monitored during the postpartum period.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Wiwanitkit V, , 2010. Non vector-borne transmission modes of dengue. J Infect Dev Ctries 4: 5154. [Google Scholar]
  2. Wilder-Smith A, Chen LH, Massad E, Wilson ME, , 2009. Threat of dengue to blood safety in dengue-endemic countries. Emerg Infect Dis 15: 8. [Google Scholar]
  3. Faddy HM, Seed CR, Fryk JJ, Hyland CA, Ritchie SA, Taylor CT, Van Der Merwe KL, Flower RL, McBride WJ, , 2013. Implications of dengue outbreaks for blood supply, Australia. Emerg Infect Dis 19: 787. [Google Scholar]
  4. Chen LH, Wilson ME, , 2004. Transmission of dengue virus without a mosquito vector: nosocomial mucocutaneous transmission and other routes of transmission. Clin Infect Dis 39: e56e60. [Google Scholar]
  5. Basurko C, Carles G, Youssef M, Guindi WE, , 2009. Maternal and fetal consequences of dengue fever during pregnancy. Eur J Obstet Gynecol Reprod Biol 147: 2932. [Google Scholar]
  6. Guzman MG, ., 2010. Dengue: a continuing global threat. Nat Rev Microbiol 8: S7S16. [Google Scholar]
  7. Bhatt S, ., 2013. The global distribution and burden of dengue. Nature 496: 504507. [Google Scholar]
  8. Burke DS, Nisalak A, Johnson DE, Scott RM, , 1988. A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg 38: 172180. [Google Scholar]
  9. Pouliot SH, Xiong X, Harville E, Paz-Soldan V, Tomashek KM, Breart G, Buekens P, , 2010. Maternal dengue and pregnancy outcomes: a systematic review. Obstet Gynecol Surv 65: 107118. [Google Scholar]
  10. Lanciotti RS, Calisher CH, Gubler DJ, Chang G-J, Vorndam AV, , 1992. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30: 545551. [Google Scholar]
  11. Dussart P, ., 2006. Evaluation of an enzyme immunoassay for detection of dengue virus NS1 antigen in human serum. Clin Vaccine Immunol 13: 11851189. [Google Scholar]
  12. Talarmin A, Labeau B, Lelarge J, Sarthou J-L, , 1998. Immunoglobulin A-specific capture enzyme-linked immunosorbent assay for diagnosis of dengue fever. J Clin Microbiol 36: 11891192. [Google Scholar]
  13. World Health Organization and the Special Programme for Research and Training in Tropical Diseases (TDR), 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. Geneva, Switzerland: World Health Organization.
  14. Peeling RW, ., 2010. Evaluation of diagnostic tests: dengue. Nat Rev Microbiol 8: S30S37. [Google Scholar]
  15. Argolo AF, Féres VC, Silveira LA, Oliveira AC, Pereira LA, Júnior JBS, Braga C, Martelli CM, , 2013. Prevalence and incidence of dengue virus and antibody placental transfer during late pregnancy in central Brazil. BMC Infect Dis 13: 254. [Google Scholar]
  16. Sirinavin S, Nuntnarumit P, Supapannachart S, Boonkasidecha S, Techasaensiri C, Yoksarn S, , 2004. Vertical dengue infection: case reports and review. Pediatr Infect Dis J 23: 10421047. [Google Scholar]
  17. Janjindamai W, Pruekprasert P, , 2003. Perinatal dengue infection: a case report and review of literature. Southeast Asian J Trop Med Public Health 34: 793796. [Google Scholar]
  18. Boussemart T, Babe P, Sibille G, Neyret C, Berchel C, , 2001. Prenatal transmission of dengue: two new cases. J Perinatol 21: 255257. [Google Scholar]
  19. Chotigeat U, Kalayanarooj S, Nisalak A, , 2003. Vertical transmission of dengue infection in Thai infants: two case reports. J Med Assoc Thai 86: S628S632. [Google Scholar]
  20. Fatimil LE, Mollah AH, Ahmed S, Rahman M, , 2003. Vertical transmission of dengue: first case report from Bangladesh. Southeast Asian J Trop Med Public Health 34: 800803. [Google Scholar]
  21. Tan PC, Rajasingam G, Devi S, Omar SZ, , 2008. Dengue infection in pregnancy: prevalence, vertical transmission, and pregnancy outcome. Obstet Gynecol 111: 11111117. [Google Scholar]
  22. Tsai H-C, Lin C-C, Hong N-S, Kuo T-N, Huang Y-Y, Lin MY-S, Loo TC, Huang KF, Wang JJ, Chen SH, , 2010. Dengue virus infection in early gestation with delivery of an unaffected fetus and no vertical transmission. Taiwan J Obstet Gynecol 49: 112114. [Google Scholar]
  23. Tan PC, Soe MZ, Si Lay K, Wang SM, Sekaran SD, Omar SZ, , 2012. Dengue infection and miscarriage: a prospective case control study. PLoS Negl Trop Dis 6: e1637. [Google Scholar]
  24. Chye JK, Lim CT, Ng KB, Lim JM, George R, Lam SK, , 1997. Vertical transmission of dengue. Clin Infect Dis 25: 13741377. [Google Scholar]
  25. Thaithumyanon P, Thisyakorn U, Deerojnawong J, Innis BL, , 1994. Dengue infection complicated by severe hemorrhage and vertical transmission in a parturient woman. Clin Infect Dis 18: 248249. [Google Scholar]
  26. Carroll ID, Toovey S, Van Gompel A, , 2007. Dengue fever and pregnancy—a review and comment. Travel Med Infect Dis 5: 183188. [Google Scholar]
  27. Barthel A, Gourinat A-C, Cazorla C, Joubert C, Dupont-Rouzeyrol M, Descloux E, , 2013. Breast milk as a possible route of vertical transmission of dengue virus? Clin Infect Dis 57: 415417. [Google Scholar]

Data & Media loading...

  • Received : 10 Oct 2016
  • Accepted : 11 Aug 2017
  • Published online : 23 Apr 2018

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error