1921
Volume 97, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Paracoccidioidomycosis (PCM) is an endemic disease in the southeast region of Brazil, which includes the state of Espírito Santo (ES). This historic case series analyses 546 patients treated in this state from 1978 to 2012. Patients aged from 7 to 83 years, 509 males and 37 females, yielding a ratio of 13.7:1. Most of the patients (81.4%) originated from rural areas in ES, 71.0% being farmers. A higher concentration of cases was observed in municipalities located along the western range of the state. Sixty patients (11.0%) had an acute/subacute form of the disease, 485 (88.9%) had a chronic form, and one had a subclinical form. The most affected organs included the lungs, oropharyngeal mucosa, lymph nodes, skin, and larynx. The diagnosis was confirmed by histopathology in 252 (46.2%) cases, direct examination in 168 (30.7%), both exams in 111 (20.3%) and serology in 15 (2.8%). Tuberculosis, acquired immune deficiency syndrome, leishmaniasis, and intestinal parasites were the most frequently associated infectious diseases. From 328 patients followed up, total regression of the lesions was observed in 17.4%, partial regression in 77.4%, and no regression in 17 (5.2%) cases. Regarding the number of cases in this series, ES emerges as an important endemic area for PCM in Brazil.

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References

  1. Bellissimo-Rodrigues F, Machado AA, Martinez R, , 2011. Paracoccidioidomycosis epidemiological features of a 1,000 cases series from a hyperendemic area on the southeast of Brazil. Am J Trop Med Hyg 85: 546550. [Google Scholar]
  2. Martinez R, , 2015. Epidemiology of paracoccidioidomycosis. Rev Inst Med Trop Sao Paulo 57: 1120. [Google Scholar]
  3. Wanke B, Londero AT, , 1994. Epidemiology and paracoccidiodomycosis infection. Franco M, Lacaz CS, Restrepo-Moreno A, Del-negro G, eds. Paracoccidioidomycosis. Boca Raton, FL: CRC Press, 109–117.
  4. Restrepo A, Tobon AM, , 2010. Paracoccidioides brasiliensis. Mandell GD, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases, 7th ed. Philadelphia, PA: Elsevier, 3357–3363.
  5. Valle ACF, Wanke B, Wanke NCF, Peixoto TC, Perez M, , 1992. Tratamento da paracoccidioidomicose, estudo retrospectivo de 500 casos I. Análise clínica, laboratorial e epidemiológica. An Bras Dermatol 67: 251254. [Google Scholar]
  6. Blotta MHSI, Mamoni RL, Oliveira SJ, Nouer S, Papaiordanou PM, Goveia A, Camargo ZP, , 1999. Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region. Am J Trop Med Hyg 61: 390394. [Google Scholar]
  7. Machado Filho J, Miranda JL, , 1961. Considerações relativas à blastomicose sulamericana. Evolução, resultados terapêuticos e moléstias associadas em 394 casos consecutivos. O Hospital (Rio) 60: 375–412.
  8. Coutinho ZF, Silva D, Lazera M, Petri V, Oliveira RM, Sabroza PC, Wanke B, , 2002. Paracoccidioidomycosis mortality in Brazil (1980–1995). Cad Saude Publica 18: 14411454. [Google Scholar]
  9. Dos Santos WA, da Silva BM, Passos ED, Zandonadi E, Falqueto A, , 2003. Association between smoking and paracoccidioidomycosis: a case-control study in the state of Espírito Santo, Brasil. Cad Saude Publica 19: 245253. [Google Scholar]
  10. Dietze R, Fowler VG, Jr Stein TS, Peçanha PM, Corey GR, , 1999. Failure of Amphotericin B coloidal dispersal in the treatment of paracoccidioidomycosis. Am J Trop Med Hyg 60: 833839. [Google Scholar]
  11. Ferrão RG, Ferrão MAG, Fonseca AFA, Lani JÁ, Ferrão LFV, , 2011. A cafeicultura no Estado do Espírito Santo: tecnologias e desafios. Tomas MA, ed. Tecnologias para sustentabilidade da cafeicultura. Alegre, ES: CAUFES, Cap 1.
  12. Shikanai-Yasuda MA, Telles Filho FQ, Mendes RP, Colombo AL, Moretti ML, , 2006. Guidelines in paracoccidioidomycosis. Rev Soc Bras Med Trop 39: 297310. [Google Scholar]
  13. Queiroz-Telles F, , 2008. Influence of alternating coffee and sugar cane agriculture in the incidence of paracoccidioidomycosis in Brazil. Biomedica 78 (Suppl 1): 129. [Google Scholar]
  14. Paniago AMM, Aguiar JIA, Aguiar ES, Cunha RV, Pereira GROL, Londero AT, Wanke B, , 2003. Paracoccidioidomicose: estudo clínico e epidemiológico de 422 casos observados no estado de Mato Grosso do Sul. Rev Soc Bras Med Trop 36: 455459. [Google Scholar]
  15. Silva-Vergara ML, Martinez R, Chadu A, Madeira M, Freitas-Silva G, Leite Maffei CM, , 1998. Isolation of Paracoccidioides brasiliensis strain from the soil of a coffee plantation in Ibiá, State of Minas Gerais, Brazil. Med Mycol 36: 3742. [Google Scholar]
  16. Restrepo A, Salazar ME, Cano LE, Stover EP, Feldman D, Stevens DA, , 1984. Estrogen inhibit mycelium-to-yeast transformation in the fungus Paracoccidioides brasiliensis: implications for resistance of females to paracoccidioidomycosis. Infect Immun 46: 346353. [Google Scholar]
  17. Campos MVS, Penna GO, Castro CN, Moraes MAP, Ferreira MS, Santos JB, , 2008. Paracoccidioidomicose no Hospital Universitário de Brasília. Rev Soc Bras Med Trop 41: 169172. [Google Scholar]
  18. Martinez R, Moya MJ, , 1992. The relationship between paracoccidioidomycosis and alcoholism. Rev Saude Publica 26: 1216. [Google Scholar]
  19. Queiroz-Telles F, Escuissato DL, , 2011. Pulmonary paracoccidioidomycosis. Semin Respir Crit Care Med 32: 764774. [Google Scholar]
  20. Marques SA, , 2003. Paracoccidioidomycosis: epidemiological, clinical and treatment update. An bras Dermatol 78: 135–150.
  21. Pereira RM, Bucaretchi F, Barison EM, Hessel G, Tresoldi AT, , 2004. Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome. Rev Inst Med Trop Sao Paulo 46: 127131. [Google Scholar]
  22. Fonseca ERS, Pardal PO, Severo LC, , 1999. Paracoccidioidomicose em crianças em Belém do Pará. Rev Soc Bras Med Trop 32: 3133. [Google Scholar]
  23. Mendes-Gianinni MJS, Del Negro GMD, Gonçalves EG, , 2015. Paracoccidioidomicose—Diagnóstico laboratorial e radiológico. Focaccia R, ed. Tratado de Infectologia, 5th ed. São Paulo, Brazil: Atheneu, 1703–1709.
  24. Bethlem NM, Lemle A, Bethlem E, Wanke B, , 1991. Paracoccidioidomycosis. Semin Respir Med 12: 81–97.
  25. Mendes RP, , 2015. Paracoccidioidomicose—Quadro clínico. Focaccia R, ed. Tratado de Infectologia, 5th ed. São Paulo, Brazil: Atheneu, 1695–1702.
  26. Nucci M, Colombo AL, Queiroz-Telles F, , 2009. Paracoccidioidomycosis. Current approaches to prophylaxis and clinical management. Curr Fungal Infect Rep 3: 1520. [Google Scholar]
  27. Costa MAB, Carvalho TC, Araújo CR, Junior Borba AOC, Veloso GA, Teixeira KS, , 2005. Manifestações extra-pulmonares da paracoccidioidomicose. Radiol Bras 38: 4552. [Google Scholar]
  28. Tendrich M, De Luca V, Tourinho EK, Wanke B, Cuba J, Buescu A, Vaisman M, Pereira AA, el-Andere W, Wajchenberg BL, , 1991. Computed tomography and ultrasonography of the adrenal glands in paracoccidioidomycosis. Comparison with cortisol and aldosterone responses to ACTH stimulation. Am J Trop Med Hyg 44: 8392. [Google Scholar]
  29. Franscesconi F, da Silva MT, Costa RL, Francesconi VA, Carregal E, Talhari S, Valle AC, , 2011. Long term outcome of neuroparacoccidioidomycosis treatment. Rev Soc Bras Med Trop 44: 2225. [Google Scholar]
  30. Pedroso VSP, Vilela MC, Pedroso ERP, Teixeira AL, , 2009. Paracoccidioidomycosis compromising the central nervous system: a systematic review of the literature. Rev Soc Bras Med Trop 42: 691697. [Google Scholar]
  31. Pedroso VSP, Lyon AN, Araújo SA, Veloso JMR, Pedroso ERP, Teixeira AL, , 2012. Paracoccidiodomycosis case series with and without central nervous system involvement. Rev Soc Bras Med Trop 45: 586590. [Google Scholar]
  32. Almeida SM, Queiroz-Telles F, Teive HAG, Ribeiro CEL, Werneck LC, , 2003. Central nervous system paracoccidioidomycosis: clinical features and laboratorial findings. J Infect 48: 193198. [Google Scholar]
  33. Marques SA, Tangoda LK, Camargo RMP, Stolf HO, Marques MEA, , 2012. Paracoccidioidomycosis of external genitalia: report of six new cases and review of literature. An Bras Dermatol 87: 235240. [Google Scholar]
  34. Rocha GJNM, Nossa LMB, Pinto MR, Marback RL, , 2002. Paracoccidioimicose palpebral: relato de 3 casos. Arq Bras Oftalmol 65: 575578. [Google Scholar]
  35. Del Negro G, , 1982. Outras lesões. Formas de ocorrência rara e associação com outros processos. Del Negro G, Lacaz CS, Fiorillo AM, eds. Paracoccidioidomicose—Blastomicose Sul-americana. São Paulo, Brazil: Sarvier EDUSP, 229–243.
  36. Borges AS, , 2015. Paracoccidioidomicose e a Infecção pelo HIV. Focaccia R, ed. Tratado de Infectologia, 5th ed. São Paulo, Brazil: Atheneu, 1702–1703.
  37. Benard G, Duarte AJS, , 2000. Paracoccidioidomycosis: a model for evaluation of the effects of human immunodeficiency virus infection on the natural history of endemic tropical diseases. Clin Infect Dis 31: 10321039. [Google Scholar]
  38. Chiarella AP, Arruda C, Pina A, Costa TA, Ferreira RCV, Calich VLG, , 2007. The relative importance of CD4+ and CD8+T cells in immunity to pulmonary paracoccidioidomycosis. Microbes Infect 9: 10781088. [Google Scholar]
  39. Shikanai-Yasuda MA, Conceição YN, Kono A, Rivitti E, Campos AF, Campos V, , 2008. Neoplasia and paracoccidioidomycosis. Mycopathologia 165: 303312. [Google Scholar]
  40. Queiroz Telles F, , 2015. Terapêutica da paracoccidioidomicose. Focaccia R, ed. Tratado de Infectologia, 5th ed. São Paulo, Brazil: Atheneu, 1710–1718.
  41. Shikanai-Yasuda MA, , 2015. Paracoccidioidomycosis treatment. Rev Inst Med Trop Sao Paulo 57: 3137. [Google Scholar]
  42. Peçanha PM, Souza S, Falqueto A, Grão-Veloso TR, Lírio LV, Ferreira CUG, Jr Santos AR, Costa HG, Souza LRM, Tuon FF, , 2016. Amphotericin B lipid complex in the treatment of severe paracoccidioidomycosis: a case series. Int J Antimicrob Agents 48: 428430. [Google Scholar]
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  • Received : 06 Oct 2016
  • Accepted : 22 May 2016
  • Published online : 24 Jul 2017

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