1921
Volume 96, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Malaria-endemic countries have to decide how much of their limited resources for vector control to allocate toward implementing long-lasting insecticidal nets (LLINs) versus indoor residual spraying (IRS). To help the Mozambique Ministry of Health use an evidence-based approach to determine funding allocation toward various malaria control strategies, the Global Fund convened the Mozambique Modeling Working Group which then used JANUS, a software platform that includes integrated computational economic, operational, and clinical outcome models that can link with different transmission models (in this case, OpenMalaria) to determine the economic value of vector control strategies. Any increase in LLINs (from 80% baseline coverage) or IRS (from 80% baseline coverage) would be cost-effective (incremental cost-effectiveness ratios ≤ $114/disability-adjusted life year averted). However, LLIN coverage increases tend to be more cost-effective than similar IRS coverage increases, except where both pyrethroid resistance is high and LLIN usage is low. In high-transmission northern regions, increasing LLIN coverage would be more cost-effective than increasing IRS coverage. In medium-transmission central regions, changing from LLINs to IRS would be more costly and less effective. In low-transmission southern regions, LLINs were more costly and less effective than IRS, due to low LLIN usage. In regions where LLINs are more cost-effective than IRS, it is worth considering prioritizing LLIN coverage and use. However, IRS may have an important role in insecticide resistance management and epidemic control. Malaria intervention campaigns are not a one-size-fits-all solution, and tailored approaches are necessary to account for the heterogeneity of malaria epidemiology.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.16-0744
2017-06-07
2017-09-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/96/6/1430.html?itemId=/content/journals/10.4269/ajtmh.16-0744&mimeType=html&fmt=ahah

References

  1. World Health Organization (WHO) United Nations Children's Fund (UNICEF), 2015. Achieving the Malaria MDG Target: Reversing the Incidence of Malaria 2000–2015. Geneva, Switzerland: WHO, UNICEF.
  2. President's Malaria Initiative, 2014. Mozambique Malaria Operational Plan FY 2014. Washington, DC: President's Malaria Initiative.
  3. Instituto Nacional de Estatística, Ministério da Saúde, MEASURE DHS, ICF International, 2011. Mozambique Demographic and Health Surveys (DHS). Rockville, MD: ICF International.
  4. President's Malaria Initiative, 2016. Mozambique Malaria Operational Plan FY 2016. Washington, DC: President's Malaria Initiative.
  5. Smith T, Killeen GF, Maire N, Ross A, Molineaux L, Tediosi F, Hutton G, Utzinger J, Dietz K, Tanner M, , 2006. Mathematical modeling of the impact of malaria vaccines on the clinical epidemiology and natural history of Plasmodium falciparum malaria: overview. Am J Trop Med Hyg 75 (Suppl): 110.
  6. Casimiro S, Coleman M, Hemingway J, Sharp B, , 2006. Insecticide resistance in Anopheles arabiensis and Anopheles gambiae from Mozambique. J Med Entomol 43: 276282.[Crossref]
  7. Abilio AP, Kleinschmidt I, Rehman AM, Cuamba N, Ramdeen V, Mthembu DS, Coetzer S, Maharaj R, Wilding CS, Steven A, Coleman M, Hemingway J, Coleman M, , 2011. The emergence of insecticide resistance in central Mozambique and potential threat to the successful indoor residual spraying malaria control programme. Malar J 10: 110.[Crossref]
  8. Kloke RG, Nhamahanga E, Hunt RH, Coetzee M, , 2011. Vectorial status and insecticide resistance of Anopheles funestus from a sugar estate in southern Mozambique. Parasit Vectors 4: 16.[Crossref]
  9. Republic of Mozambique Ministry of Health National Directorate of Public Health, 2013. Programa Nacional de Controlo da Malaria: Integrated Vector Management Strategy and Insecticide Resistance Management for Malaria Vector Control in Mozambique. Maputo, Mozambique: Ministry of Health.
  10. Malaria Atlas Project, 2011. The Spatial Distribution of Plasmodium falciparum Entomological Inoculation Rate Map in 2010 in Mozambique UK: Malaria Atlas Project. Available at: http://www.map.ox.ac.uk/browse-resources/entomological-innoculation-rate/Pf_EIR/MOZ/. Accessed August 20, 2014.
  11. World Vision, 2012. Baseline Survey on Malaria Related Knowledge, Attitudes, Practices and Behaviors. Maputo, Mozambique: AustralCOWI.
  12. Republic of Mozambique Ministry of Health, 2009. National Malaria Indicator Survey, Mozambique (MIS-2007). Maputo, Mozambique: Ministry of Health.
  13. The World Bank, 2016. World Development Indicators, 1960–2015. Washington, DC: The World Bank.
  14. Sangare LR, Weiss NS, Brentlinger PE, Richardson BA, Staedke SG, Kiwuwa MS, Stergachis A, , 2012. Determinants of use of insecticide treated nets for the prevention of malaria in pregnancy: Jinja, Uganda. PLoS One 7: e39712.[Crossref]
  15. Toe LP, Skovmand O, Dabire KR, Diabate A, Diallo Y, Guiguemde TR, Doannio JM, Akogbeto M, Baldet T, Gruénais ME, , 2009. Decreased motivation in the use of insecticide-treated nets in a malaria endemic area in Burkina Faso. Malar J 8: 175.[Crossref]
  16. Augustincic Polec L, Petkovic J, Welch V, Ueffing E, Tanjong Ghogomu E, Pardo Pardo J, Grabowsky M, Attaran A, Wells GA, Tugwell P, , 2015. Strategies to increase the ownership and use of insecticide-treated bednets to prevent malaria. Cochrane Database Syst Rev 3: CD009186.
  17. Curtis CF, Miller JE, Hodjati MH, Kolaczinski JH, Kasumba I, , 1998. Can anything be done to maintain the effectiveness of pyrethroid-impregnated bednets against malaria vectors? Philos Trans R Soc Lond B Biol Sci 353: 17691775.[Crossref]
  18. Nauen R, , 2007. Insecticide resistance in disease vectors of public health importance. Pest Manag Sci 63: 628633.[Crossref]
  19. Kolaczinski JH, Curtis CF, , 2004. Investigation of negative cross-resistance as a resistance-management tool for insecticide-treated nets. J Med Entomol 41: 930934.[Crossref]
  20. Hougard JM, Corbel V, N'Guessan R, Darriet F, Chandre F, Akogbeto M, Baldet T, Guillet P, Carnevale P, Traoré-Lamizana M, , 2003. Efficacy of mosquito nets treated with insecticide mixtures or mosaics against insecticide resistant Anopheles gambiae and Culex quinquefasciatus (Diptera: Culicidae) in Cote d'Ivoire. Bull Entomol Res 93: 491498.[Crossref]
  21. Boene H, Gonzalez R, Vala A, Ruperez M, Velasco C, Machevo S, Sacoor C, Sevene E, Macete E, Menéndez C, Munguambe K, , 2014. Perceptions of malaria in pregnancy and acceptability of preventive interventions among Mozambican pregnant women: implications for effectiveness of malaria control in pregnancy. PLoS One 9: e86038.[Crossref]
  22. Ingabire CM, Rulisa A, Van Kempen L, Muvunyi C, Koenraadt CJ, Van Vugt M, Mutesa L, Van Den Borne B, Alaii J, , 2015. Factors impeding the acceptability and use of malaria preventive measures: implications for malaria elimination in eastern Rwanda. Malar J 14: 136.[Crossref]
  23. Kaufman MR, Rweyemamu D, Koenker H, Macha J, , 2012. “My children and I will no longer suffer from malaria”: a qualitative study of the acceptance and rejection of indoor residual spraying to prevent malaria in Tanzania. Malar J 11: 220.[Crossref]
  24. Rodriguez AD, Penilla RP, Rodriguez MH, Hemingway J, Trejo A, Hernandez-Avila JE, , 2006. Acceptability and perceived side effects of insecticide indoor residual spraying under different resistance management strategies. Salud Publica Mex 48: 317324.[Crossref]
  25. Montgomery CM, Munguambe K, Pool R, , 2010. Group-based citizenship in the acceptance of indoor residual spraying (IRS) for malaria control in Mozambique. Soc Sci Med 70: 16481655.[Crossref]
  26. Obembe A, Anyaele OO, Oduola AO, , 2014. Lessons from the implementation of LLIN distribution campaign in Ilorin Kwara State, Nigeria. BMC Public Health 14: 514.[Crossref]
  27. Minakawa N, Dida GO, Sonye GO, Futami K, Kaneko S, , 2008. Unforeseen misuses of bed nets in fishing villages along Lake Victoria. Malar J 7: 165.[Crossref]
  28. Kayedi MH, Lines JD, Haghdoost AA, Vatandoost MH, Rassi Y, Khamisabady K, , 2008. Evaluation of the effects of repeated hand washing, sunlight, smoke and dirt on the persistence of deltamethrin on insecticide-treated nets. Trans R Soc Trop Med Hyg 102: 811816.[Crossref]
  29. Atieli FK, Munga SO, Ofulla AV, Vulule JM, , 2010. The effect of repeated washing of long-lasting insecticide-treated nets (LLINs) on the feeding success and survival rates of Anopheles gambiae . Malar J 9: 304.[Crossref]
  30. Nyunt MH, Aye KM, Kyaw MP, Kyaw TT, Hlaing T, Oo K, Zaw NN, Aye TT, San NA, , 2014. Challenges in universal coverage and utilization of insecticide-treated bed nets in migrant plantation workers in Myanmar. Malar J 13: 211.[Crossref]
  31. Lee BY, , 2008. Digital decision making: computer models and antibiotic prescribing in the twenty-first century. Clin Infect Dis 46: 11391141.[Crossref]
  32. Conteh L, Sicuri E, Manzi F, Guy H, Obonyo B, Tediosi F, Biao P, Masika P, Matovu F, Otieno P, Gosling RD, Hamel M, Odhiambo FO, Grobusch MP, Kremsner PG, Chandramohan D, Aponte JJ, Egan A, Schellenberg D, Macete E, Slutsker L, Newman RD, Alonso P, Menéndez C, Tanner M, , 2010. The cost-effectiveness of intermittent preventive treatment for malaria in infants in sub-Saharan Africa. PLoS One 5: e10313.[Crossref]
  33. World Health Organization, 2008. WHO-CHOICE Unit Cost Estimates for Service Delivery 2007–2008. Geneva, Switzerland: World Health Organization.
  34. Chanda P, Masiye F, Chitah BM, Sipilanyambe N, Hawela M, Banda P, Okorosobo T, , 2007. A cost-effectiveness analysis of artemether lumefantrine for treatment of uncomplicated malaria in Zambia. Malar J 6: 21.[Crossref]
  35. Lubell Y, Riewpaiboon A, Dondorp AM, von Seidlein L, Mokuolu OA, Nansumba M, Gesase S, Kent A, Mtove G, Olaosebikan R, Ngum WP, Fanello CI, Hendriksen I, Day NP, White NJ, Yeung S, , 2011. Cost-effectiveness of parenteral artesunate for treating children with severe malaria in sub-Saharan Africa. Bull World Health Organ 89: 504512.[Crossref]
  36. Berg A, Patel S, Aukrust P, David C, Gonca M, Berg ES, Dalen I, Langeland N, , 2014. Increased severity and mortality in adults co-infected with malaria and HIV in Maputo, Mozambique: a prospective cross-sectional study. PLoS One 9: e88257.[Crossref]
  37. Bassat Q, Guinovart C, Sigauque B, Aide P, Sacarlal J, Nhampossa T, Bardají A, Nhacolo A, Macete E, Mandomando I, Aponte JJ, Menéndez C, Alonso PL, , 2008. Malaria in rural Mozambique. Part II: children admitted to hospital. Malar J 7: 37.[Crossref]
  38. Dondorp AM, Lee SJ, Faiz MA, Mishra S, Price R, Tjitra E, Than M, Htut Y, Mohanty S, Yunus EB, Rahman R, Nosten F, Anstey NM, Day NP, White NJ, , 2008. The relationship between age and the manifestations of and mortality associated with severe malaria. Nephrol Dial Transplant 47: 151157.
  39. Cooper NJ, Sutton AJ, Abrams KR, Wailoo A, Turner DA, Nicholson KG, , 2003. Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analysis of randomised controlled trials. BMJ 326: 1235.[Crossref]
  40. Nhama A, Bassat Q, Enosse S, Nhacolo A, Mutemba R, Carvalho E, Naueia E, Sevene E, Guinovart C, Warsame M, Sanz S, Mussa A, Matsinhe G, Alonso P, Tiago A, Macete E, , 2014. In vivo efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated falciparum malaria in children: a multisite, open-label, two-cohort, clinical trial in Mozambique. Malar J 13: 309.[Crossref]
  41. Ogutu B, , 2013. Artemether and lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa. Expert Opin Pharmacother 14: 643654.[Crossref]
  42. Sylla K, Abiola A, Tine RCK, Faye B, Sow D, Ndiaye JL, Ndiaye M, Lo AC, Folly K, Ndiaye LA, Gaye O, , 2013. Monitoring the efficacy and safety of three artemisinin based-combinations therapies in Senegal: results from two years surveillance. BMC Infect Dis 13: 598.[Crossref]
  43. Hume JC, Barnish G, Mangal T, Armazio L, Streat E, Bates I, , 2008. Household cost of malaria overdiagnosis in rural Mozambique. Malar J 7: 33.[Crossref]
  44. Abacassamo F, Enosse S, Aponte JJ, Gomez-Olive FX, Quinto L, Mabunda S, Barreto A, Magnussen P, Rønn AM, Thompson R, Alonso PL, , 2004. Efficacy of chloroquine, amodiaquine, sulphadoxine-pyrimethamine and combination therapy with artesunate in Mozambican children with non-complicated malaria. Trop Med Int Health 9: 200208.[Crossref]
  45. Allen EN, Little F, Camba T, Cassam Y, Raman J, Boulle A, Barnes KI, , 2009. Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial. Malar J 8: 141.[Crossref]
  46. Sicuri E, Vieta A, Lindner L, Constenla D, Sauboin C, , 2013. The economic costs of malaria in children in three sub-Saharan countries: Ghana, Tanzania and Kenya. Malar J 12: 307.[Crossref]
  47. Castillo-Riquelme M, McIntyre D, Barnes K, , 2008. Household burden of malaria in South Africa and Mozambique: is there a catastrophic impact? Trop Med Int Health 13: 108122.[Crossref]
  48. World Health Organization, 2008. The Global Burden of Disease: 2004 Update. Geneva, Switzerland: World Health Organization.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.16-0744
Loading
/content/journals/10.4269/ajtmh.16-0744
Loading

Data & Media loading...

Supplementary Data

Supplemental Appendix

  • Received : 12 Sep 2016
  • Accepted : 03 Feb 2017

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error